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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 4
1989 42
1990 120
1991 124
1992 136
1993 142
1994 161
1995 159
1996 170
1997 191
1998 190
1999 227
2000 291
2001 352
2002 419
2003 467
2004 512
2005 628
2006 760
2007 801
2008 958
2009 904
2010 1154
2011 1263
2012 1396
2013 1367
2014 1269
2015 1226
2016 1301
2017 1201
2018 1228
2019 679
2020 11
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17,504 results
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Page 1
Small-Molecule Kinase Downregulators
Jones LH. Cell Chem Biol 2018 - Review. PMID 29174540 Free article.
Gene expression regulation by retinoic acid.
Balmer JE and Blomhoff R. J Lipid Res 2002 - Review. PMID 12401878 Free article.
Data on another 267 targets are not evocative of direct or indirect regulation either way, although control by retinoic acid through some mechanism is clear (Category 1). ...
Data on another 267 targets are not evocative of direct or indirect regulation either way, although control by retinoic acid through …
Down-regulation of senescence marker protein 30 by iron-specific chelator deferoxamine drives cell senescence.
Inoue H, et al. Biosci Biotechnol Biochem 2018. PMID 29490582
To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific chelator deferoxamine (DFO) on FAO cell senescence, using a DNA microarray. ...Our data suggested that down-regulation of SMP30 drives cell senescence in iron-chelated condition....
To our knowledge, this is the first study to report down-regulation of senescence marker protein 30 (SMP30) by iron-specific c …
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Perryman MS, et al. Bioorg Med Chem 2016. PMID 27475534
Constrained analogs containing a 2-hydroxymethylpyrrolidine core of the natural sphingolipids sphingosine, sphinganine, N,N-dimethylsphingosine and N-acetyl variants of sphingosine and sphinganine (C2-ceramide and dihydro-C2-ceramide) were synthesized and evaluated for their ability to down-regulate nutrient transporter proteins and trigger cytoplasmic vacuolation in mammalian cells. ...In general, cytotoxicity was positively correlated with nutrient transporter down-regulation and vacuolation. This study was intended to identify structural and functional features in lead compounds that best contribute to potency, and to develop chemical biology tools that could be used to isolate the different protein targets responsible for nutrient transporter loss and cytoplasmic vacuolation. ...
Constrained analogs containing a 2-hydroxymethylpyrrolidine core of the natural sphingolipids sphingosine, sphinganine, N,N-dimethylsphingos …
Mechanisms of resistance to selective estrogen receptor down-regulator in metastatic breast cancer.
Huang D, et al. Biochim Biophys Acta Rev Cancer 2017 - Review. PMID 28344099
Fulvestrant, the first selective ER down-regulator (SERD), was demonstrated to completely suppress ERα and notably efficient. ...
Fulvestrant, the first selective ER down-regulator (SERD), was demonstrated to completely suppress ERα and notably efficient. ...
Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation
Liu A, et al. Haematologica 2018. PMID 29954930 Free PMC article.
Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic progenitors and upregulate megakaryocytic colonies by inhibiting apoptosis and increasing proliferation of early megakaryocytic progenitors via down-regulation of IKZF1. ...The down-regulation of GATA1 further decreases CCND1 and increases CDKN2A expression. Overexpression of GATA1 abrogated the effects of the immunomodulatory drugs and restored maturation of megakaryocytic progenitors. ...
Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic progenitors and upregulate megakaryocytic colonies …
A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction
Shi XQ, et al. J Ethnopharmacol 2019. PMID 30703496
Whole pharmacodynamic experiments showed that DBD had significant effects to blood loss rats. Furthermore, DBD could promote the up-regulation of hematopoietic and immune related targets and the down-regulation of inflammatory related targets. ...
Whole pharmacodynamic experiments showed that DBD had significant effects to blood loss rats. Furthermore, DBD could promote the up- …
β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells
Okamoto S, et al. Sci Rep 2018. PMID 30573743 Free PMC article.
To examine the glutamate receptor-independent toxicity of BMAA, we investigated the effects of BMAA in non-neuronal cell lines. ...
To examine the glutamate receptor-independent toxicity of BMAA, we investigated the effects of BMAA in non-neuronal cell lines. ...
Honokiol is a FOXM1 antagonist
Halasi M, et al. Cell Death Dis 2018. PMID 29367668 Free PMC article.
Honokiol is a natural product and an emerging drug for a wide variety of malignancies, including hematopoietic malignancies, sarcomas, and common epithelial tumors. ...
Honokiol is a natural product and an emerging drug for a wide variety of malignancies, including hematopoietic malignancies, sarcomas …
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