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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 4
1946 32
1947 36
1948 15
1949 10
1950 24
1951 41
1952 44
1953 65
1954 78
1955 55
1956 71
1957 55
1958 67
1959 62
1960 69
1961 84
1962 93
1963 76
1964 108
1965 41
1966 2
1967 4
1968 11
1969 17
1970 91
1971 318
1972 1024
1973 1031
1974 939
1975 968
1976 866
1977 791
1978 851
1979 851
1980 866
1981 932
1982 1096
1983 1146
1984 1424
1985 1467
1986 1495
1987 1313
1988 1348
1989 1263
1990 1161
1991 1109
1992 1143
1993 1184
1994 1218
1995 1259
1996 1227
1997 1223
1998 1193
1999 1249
2000 1228
2001 1397
2002 1633
2003 1882
2004 2016
2005 2179
2006 2372
2007 2307
2008 2186
2009 2388
2010 2336
2011 2504
2012 2601
2013 2553
2014 2541
2015 2617
2016 2524
2017 2371
2018 2230
2019 1065
2020 26
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72,209 results
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Page 1
Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer.
Malyutina A, et al. PLoS Comput Biol 2019. PMID 31107860 Free PMC article.
High-throughput drug screening has facilitated the discovery of drug combinations in cancer. Many existing studies adopted a full matrix design, aiming for the characterization of drug pair effects for cancer cells. ...To assess the degree of drug interactions using the cross design, we developed an S synergy score based on the difference between the drug combination and the single drug dose-response curves. ...
High-throughput drug screening has facilitated the discovery of drug combinations in cancer. Many existing studies adop …
Screening drug target combinations in disease-related molecular networks.
Luo M, et al. BMC Bioinformatics 2019. PMID 31074386 Free PMC article.
In our strategy of screening drug target combinations, we first classified all drug targets into sensitive and insensitive single drug targets. Then, we identified the synergistic and antagonistic of drug target combinations, including the combinations of sensitive drug targets, the combinations of insensitive drug target and the combination of sensitive and insensitive targets. ...
In our strategy of screening drug target combinations, we first classified all drug targets into sensitive and insensit …
Two-Drug Combinations as First-Step Antihypertensive Treatment.
Mancia G, et al. Circ Res 2019 - Review. PMID 30920930
A further important factor favoring poor BP control is the limited use of combination drug treatment, despite evidence of its superior ability to control BP in patients with difficult-to-treat hypertension. ...Empahsis will be given to the drug combination treatment as first step of the antihypertensive therapeutic intervention. The potential drawbacks and barriers to combination drug treatment as initial therapeutic strategy will also be briefly discussed....
A further important factor favoring poor BP control is the limited use of combination drug treatment, despite evidence of its …
Prediction of Synergistic Drug Combinations by Learning from Deep Representations of Multiple Networks.
Hu P, et al. Stud Health Technol Inform 2019. PMID 31438192
Drug combination therapy can improve drug efficacy, reduce drug dosage, and overcome drug resistance. Many studies have focused on predicting synergistic drug combinations. However, existing methods fail to consider the heterogeneous characteristics of drugs fully, and it is difficult to identify effective drug combinations. ...
Drug combination therapy can improve drug efficacy, reduce drug dosage, and overcome drug resistance. Man
Clinical update on hypomethylating agents
Duchmann M and Itzykson R. Int J Hematol 2019 - Review. PMID 31020568
Besides optimized use at different stages of the disease, most of the expected clinical progress with HMAs will come from the development of second-generation compounds orally available and/or with improved pharmacokinetics, and from the search, so far mostly empirical, of HMA-based synergistic drug combinations....
Besides optimized use at different stages of the disease, most of the expected clinical progress with HMAs will come from the development of …
New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship
Jean SS, et al. Drugs 2019 - Review. PMID 30972660
A gradual rise in drug-resistant trends among Gram-negative organisms, especially carbapenem-resistant (CR) Enterobacteriaceae (CRE), CR-Pseudomonas aeruginosa, and extensively-drug-resistant (XDR) Acinetobacter baumannii, poses an enormous threat to healthcare systems worldwide. ...Some of these novel antibiotics against CRE strains are β-lactam/β-lactamase-inhibitor combination agents, while others belong to the non-β-lactam class. ...
A gradual rise in drug-resistant trends among Gram-negative organisms, especially carbapenem-resistant (CR) Enterobacteriaceae (CRE), …
Parkinson Disease
Zesiewicz TA. Continuum (Minneap Minn) 2019 - Review. PMID 31356286
Polypill for Cardiovascular Disease Prevention in an Underserved Population
Muñoz D, et al. N Engl J Med 2019 - Clinical Trial. PMID 31532959 Free PMC article.
The use of combination pills (also called "polypills") containing low doses of medications with proven benefits for the prevention of cardiovascular disease may be beneficial in such persons. ...
The use of combination pills (also called "polypills") containing low doses of medications with proven benefits for the prevention of …
Hot topics in opioid pharmacology: mixed and biased opioids
Azzam AAH, et al. Br J Anaesth 2019 - Review. PMID 31010646
These produce analgesia, but also the adverse-effect profile that currently defines this drug class: ventilatory depression, tolerance, and abuse liability. ...
These produce analgesia, but also the adverse-effect profile that currently defines this drug class: ventilatory depression, toleranc …
72,209 results
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