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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1999 1
2001 3
2002 4
2003 3
2004 3
2005 8
2006 10
2007 12
2008 168
2009 927
2010 1096
2011 1374
2012 1386
2013 1537
2014 1709
2015 1928
2016 1930
2017 1805
2018 1700
2019 750
2020 21
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14,530 results
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Page 1
Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud JP, et al. Nat Rev Drug Discov 2018 - Review. PMID 29880918
Historically, its potential for application in drug discovery has been heavily limited by two issues: the minimum size of the structures it can be used to study and the resolution of the images. ...This article describes the recent advances in the field and critically assesses their relevance for drug discovery as well as discussing at what stages of the drug discovery pipeline cryo-EM can be useful today and what to expect in the near future....
Historically, its potential for application in drug discovery has been heavily limited by two issues: the minimum size of the …
Automating drug discovery.
Schneider G. Nat Rev Drug Discov 2018 - Review. PMID 29242609
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in which various characteristics of compounds - including efficacy, pharmacokinetics and safety - need to be optimized in parallel to provide drug candidates. ...This could potentially accelerate time frames for compound discovery and optimization and enable more effective searches of chemical space. ...
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in which various characteristics of comp …
Induced protein degradation: an emerging drug discovery paradigm.
Lai AC and Crews CM. Nat Rev Drug Discov 2017 - Review. PMID 27885283 Free PMC article.
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function, and this approach typically precludes targeting proteins that lack such amenable sites. ...Induced protein degradation is an alternative approach that is event-driven: upon drug binding, the target protein is tagged for elimination. ...
Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function, …
Organs-on-chips at the frontiers of drug discovery.
Esch EW, et al. Nat Rev Drug Discov 2015 - Review. PMID 25792263 Free PMC article.
Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology....
Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug d
Drug discovery in academia.
Shamas-Din A and Schimmer AD. Exp Hematol 2015 - Review. PMID 25912018
Participation of academic centers in aspects of drug discovery and development beyond target identification and clinical trials is rapidly increasing. Yet many academic drug discovery projects continue to stall at the level of chemical probes, and they infrequently progress to drugs suitable for clinical trials. ...
Participation of academic centers in aspects of drug discovery and development beyond target identification and clinical trial …
["Drug" Discovery with the Help of Organic Chemistry].
Itoh Y and Suzuki T. Yakugaku Zasshi 2017 - Review. PMID 28250322 Japanese. Free article.
The first step in "drug" discovery is to find compounds binding to a potential drug target. In modern medicinal chemistry, the screening of a chemical library, structure-based drug design, and ligand-based drug design, or a combination of these methods, are generally used for identifying the desired compounds. ...In this review, we present drug discovery with the help of organic chemistry showing examples of our explorative studies on histone deacetylase inhibitors and lysine-specific demethylase 1 inhibitors....
The first step in "drug" discovery is to find compounds binding to a potential drug target. In modern medicinal chemist …
Therapeutic peptides: Historical perspectives, current development trends, and future directions
Lau JL and Dunn MK. Bioorg Med Chem 2018 - Review. PMID 28720325 Free article.
Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of structures identified from other natural sources or through medicinal chemistry efforts. ...
Peptide drug discovery has diversified beyond its traditional focus on endogenous human peptides to include a broader range of …
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