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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 66
2003 51
2004 55
2005 57
2006 61
2007 60
2008 63
2009 71
2010 97
2011 112
2012 118
2013 119
2014 104
2015 85
2016 90
2017 58
2018 59
2019 76
2020 22
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1,170 results
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Organ/body-on-a-chip based on microfluidic technology for drug discovery.
Kimura H, et al. Drug Metab Pharmacokinet 2018 - Review. PMID 29175062 Free article.
Although animal experiments are indispensable for preclinical screening in the drug discovery process, various issues such as ethical considerations and species differences remain. ...However, it remains difficult to accurately predict drug efficacy, toxicity, and organs interactions, because cultivated cells often do not retain their original organ functions and morphologies in conventional in vitro cell culture systems. ...
Although animal experiments are indispensable for preclinical screening in the drug discovery process, various issues such as ethical …
Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery.
Naritomi Y, et al. Drug Metab Pharmacokinet 2018 - Review. PMID 29183653
Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles and drug-drug interactions (DDIs). ...Since human drug metabolizing enzymes are expressed in the liver of these mice, they are regarded as suitable models for mimicking the drug metabolism and PK observed in humans; therefore, these mice are useful for predicting human drug metabolism and PK. ...
Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to …
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.
Fujiwara R, et al. Drug Metab Pharmacokinet 2018 - Review. PMID 29079228 Free PMC article.
Inhibition or induction of UGT can result in an increase or decrease in blood drug concentration. To avoid drug-drug interactions and adverse drug reactions in individuals, therefore, it is important to understand whether UGTs are involved in metabolism of drugs and drug candidates. ...Animals such as mice and rats are widely used to predict drug metabolism and drug-induced toxicity in humans. However, there are marked species differences in the expression and function of drug-metabolizing enzymes including UGTs. ...
Inhibition or induction of UGT can result in an increase or decrease in blood drug concentration. To avoid drug-drug in …
Antibody-based therapeutics
Tachibana T and Kuwabara T. Drug Metab Pharmacokinet 2019. PMID 30771882
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