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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 16
1992 39
1993 38
1994 33
1995 51
1996 37
1997 80
1998 106
1999 88
2000 75
2001 84
2002 92
2003 104
2004 154
2005 149
2006 150
2007 166
2008 173
2009 174
2010 251
2011 330
2012 299
2013 351
2014 339
2015 374
2016 370
2017 368
2018 335
2019 163
2020 2
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4,486 results
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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.
Martinez Molina D, et al. Science 2013. PMID 23828940 Free article.
The efficacy of therapeutics is dependent on a drug binding to its cognate target. Optimization of target engagement by drugs in cells is often challenging, because drug binding cannot be monitored inside cells. ...Using this assay, we validated drug binding for a set of important clinical targets and monitored processes of drug transport and activation, off-target effects and drug resistance in cancer cell lines, as well as drug distribution in tissues. ...
The efficacy of therapeutics is dependent on a drug binding to its cognate target. Optimization of target engagement by drugs in cell …
Therapeutic drug monitoring in neonates.
Pauwels S and Allegaert K. Arch Dis Child 2016 - Review. PMID 26803050
Therapeutic drug monitoring (TDM) aims to integrate drug measurement results into clinical decision making. The basic rules apply when using TDM in neonates (aminoglycosides, vancomycin, phenobarbital, digoxin), but additional factors should also be taken into account. ...
Therapeutic drug monitoring (TDM) aims to integrate drug measurement results into clinical decision making. The basic r …
Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?
Muller AE, et al. Drugs 2018 - Review. PMID 29476349
Therapeutic drug monitoring (TDM) of serum antibiotic concentrations is the most practical means of assessing adequate antibiotic exposure, though until recently, it has been underutilised for this end. ...
Therapeutic drug monitoring (TDM) of serum antibiotic concentrations is the most practical means of assessing adequate antibio …
Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring.
Sennoga CA, et al. Expert Opin Drug Deliv 2017 - Review. PMID 27892760
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. ...Our expert opinion focusses on results and prospects of using ultrasound and microbubbles as a dual modality for drug delivery and therapeutic monitoring. ...
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into mo …
Therapeutic drug monitoring of anti-infective agents in critically ill patients.
Jager NG, et al. Expert Rev Clin Pharmacol 2016 - Review. PMID 27018631
Therapeutic drug monitoring (TDM) may assist to overcome this problem. We discuss the available evidence on the use of TDM in critically ill patient populations for a number of anti-infective agents, including aminoglycosides, β-lactams, glycopeptides, antifungals and antivirals. ...For aminoglycosides, glycopeptides and voriconazole, beneficial effects of TDM have been established on both drug effectiveness and potential side effects. ...
Therapeutic drug monitoring (TDM) may assist to overcome this problem. We discuss the available evidence on the use of TDM in …
Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies.
Patsalos PN, et al. Epilepsia 2008. PMID 18397299 Free article.
Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context. Situations in which AED measurements are most likely to be of benefit include (1) when a person has attained the desired clinical outcome, to establish an individual therapeutic concentration which can be used at subsequent times to assess potential causes for a change in drug response; (2) as an aid in the diagnosis of clinical toxicity; (3) to assess compliance, particularly in patients with uncontrolled seizures or breakthrough seizures; (4) to guide dosage adjustment in situations associated with increased pharmacokinetic variability (e.g., children, the elderly, patients with associated diseases, drug formulation changes); (5) when a potentially important pharmacokinetic change is anticipated (e.g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin....
Although no randomized studies have demonstrated a positive impact of therapeutic drug monitoring (TDM) on clinical outcome in …
Therapeutic drug monitoring to improve outcome of anti-TNF drugs in pediatric inflammatory bowel disease.
Franca R, et al. Expert Opin Drug Metab Toxicol 2019 - Review. PMID 31177858
Areas covered: This review focuses on therapeutic drug monitoring (TDM) of anti-TNF levels and antidrug antibodies (ADAs), in IBD children. ...Expert opinion: Although there is a consensus across studies that higher anti-TNF trough levels are associated with a better clinical outcome, and that early anti-TNF serum measurements could be predictive of long-term response, it is still not clear what the best predictive time of sampling is and what the ideal target drug plasma concentration to achieve. ...
Areas covered: This review focuses on therapeutic drug monitoring (TDM) of anti-TNF levels and antidrug antibodies (ADAs), in …
Direct-acting oral anticoagulant drug level monitoring in clinical patient management.
Rottenstreich A, et al. J Thromb Thrombolysis 2018. PMID 29532414
While no benefit of routine DOAC monitoring was observed, drug level measurement has an important role in the management of patients in selected circumstances. Age, body weight and creatinine clearance were found to be significant predictors of drug levels. Future studies are warranted to establish associations between drug levels and outcomes, and better delineate the role of DOAC monitoring....
While no benefit of routine DOAC monitoring was observed, drug level measurement has an important role in the management of pa …
Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring.
Shipkova M and Christians U. Ther Drug Monit 2019. PMID 30883504 Free PMC article.
Although the monitoring of drug therapies based on the determination of drug concentrations in biological materials is certainly an important instrument for individualized dosing and dose adjustment with a broad variety of pharmaceuticals, its role is limited by the fact that it does not reflect pharmacodynamic (PD) and toxicodynamic interactions such as those caused by individual and environment-related factors. However, these interactions are important for both the efficacy and the safety of the drug therapy. Therefore, during recent years, there is an increased interest in personalized drug therapy as reflected by the development and clinical implementation of molecular "biomarkers" that are direct or surrogate markers of pharmacological effects [PD therapeutic drug monitoring (TDM)]. ...
Although the monitoring of drug therapies based on the determination of drug concentrations in biological materials is …
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