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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1932 1
1933 2
1944 1
1946 2
1947 8
1948 5
1949 5
1950 1
1951 5
1952 19
1953 140
1954 108
1955 113
1956 73
1957 36
1958 40
1959 29
1960 28
1961 88
1962 209
1963 606
1964 889
1965 652
1966 613
1967 813
1968 976
1969 1023
1970 991
1971 1188
1972 1291
1973 1273
1974 1436
1975 1282
1976 1292
1977 1369
1978 1415
1979 1540
1980 1457
1981 1562
1982 1718
1983 2011
1984 2257
1985 2315
1986 2555
1987 2657
1988 3064
1989 4041
1990 4991
1991 5676
1992 6600
1993 7568
1994 9134
1995 10289
1996 11573
1997 12538
1998 13970
1999 15131
2000 16778
2001 19009
2002 20705
2003 22763
2004 25489
2005 27508
2006 30018
2007 31603
2008 33825
2009 35933
2010 40036
2011 43675
2012 46749
2013 49676
2014 52870
2015 55189
2016 55920
2017 57860
2018 61063
2019 64783
2020 69405
2021 69480
2022 56434
2023 54662
2024 36336
2025 9

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1,104,190 results

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Page 1
Rho GTPase signaling in cancer progression and dissemination.
Crosas-Molist E, Samain R, Kohlhammer L, Orgaz JL, George SL, Maiques O, Barcelo J, Sanz-Moreno V. Crosas-Molist E, et al. Physiol Rev. 2022 Jan 1;102(1):455-510. doi: 10.1152/physrev.00045.2020. Epub 2021 Sep 20. Physiol Rev. 2022. PMID: 34541899 Free article. Review.
Rho GTPases play a major role in cell migration and in the metastatic process. They are also involved in interactions with the tumor microenvironment and regulate inflammation, contributing to cancer progression. ...
Rho GTPases play a major role in cell migration and in the metastatic process. They are also involved in interactions with the …
Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics.
Tirier SM, Mallm JP, Steiger S, Poos AM, Awwad MHS, Giesen N, Casiraghi N, Susak H, Bauer K, Baumann A, John L, Seckinger A, Hose D, Müller-Tidow C, Goldschmidt H, Stegle O, Hundemer M, Weinhold N, Raab MS, Rippe K. Tirier SM, et al. Nat Commun. 2021 Nov 29;12(1):6960. doi: 10.1038/s41467-021-26951-z. Nat Commun. 2021. PMID: 34845188 Free PMC article.
Relapsed/refractory multiple myeloma (RRMM) is accompanied by the clonal evolution of myeloma cells with heterogeneous genomic aberrations and profound changes of the bone marrow microenvironment (BME). However, the molecular mechanisms that drive drug res
Relapsed/refractory multiple myeloma (RRMM) is accompanied by the clonal evolution of myeloma cells with heterogeneous genomic aberrations a …
Molecular principles of metastasis: a hallmark of cancer revisited.
Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y. Fares J, et al. Signal Transduct Target Ther. 2020 Mar 12;5(1):28. doi: 10.1038/s41392-020-0134-x. Signal Transduct Target Ther. 2020. PMID: 32296047 Free PMC article. Review.
Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenge …
Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mob …
Anticancer drug resistance: An update and perspective.
Nussinov R, Tsai CJ, Jang H. Nussinov R, et al. Drug Resist Updat. 2021 Dec;59:100796. doi: 10.1016/j.drup.2021.100796. Epub 2021 Dec 16. Drug Resist Updat. 2021. PMID: 34953682 Free PMC article. Review.
Pharmacological treatment can inhibit the action of the mutant protein; however, drug resistance almost invariably emerges. Multiple studies revealed that cancer drug resistance is based upon a plethora of distinct mechanisms. ...Redundant or parallel …
Pharmacological treatment can inhibit the action of the mutant protein; however, drug resistance almost invariably emerges. Mu …
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance.
Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK. Mashouri L, et al. Mol Cancer. 2019 Apr 2;18(1):75. doi: 10.1186/s12943-019-0991-5. Mol Cancer. 2019. PMID: 30940145 Free PMC article. Review.
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenvironment (TME) remodeling, angiogenesis, invasion, metastasis and drug-resistance. ...More importantly, we discuss extensively …
Tumor-derived exosomes (TDEs) participate in formation and progression of different cancer processes, including tumor microenviron
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer.
Bao MH, Wong CC. Bao MH, et al. Cells. 2021 Jul 6;10(7):1715. doi: 10.3390/cells10071715. Cells. 2021. PMID: 34359884 Free PMC article. Review.
Hypoxia, low oxygen (O(2)) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms. In t …
Hypoxia, low oxygen (O(2)) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fata …
Molecular Mechanisms of Treatment Resistance in Glioblastoma.
Ou A, Yung WKA, Majd N. Ou A, et al. Int J Mol Sci. 2020 Dec 31;22(1):351. doi: 10.3390/ijms22010351. Int J Mol Sci. 2020. PMID: 33396284 Free PMC article. Review.
The challenges of treating glioblastoma are many and include inadequate drug or agent delivery across the blood-brain barrier, abundant intra- and intertumoral heterogeneity, redundant signaling pathways, and an immunosuppressive microenvironment. Here, we review the innate and a …
The challenges of treating glioblastoma are many and include inadequate drug or agent delivery across the blood-brain barrier, abundant intr …
Advances in Osteosarcoma.
Panez-Toro I, Muñoz-García J, Vargas-Franco JW, Renodon-Cornière A, Heymann MF, Lézot F, Heymann D. Panez-Toro I, et al. Curr Osteoporos Rep. 2023 Aug;21(4):330-343. doi: 10.1007/s11914-023-00803-9. Epub 2023 Jun 17. Curr Osteoporos Rep. 2023. PMID: 37329384 Free PMC article. Review.
However, the most recent clinical trials show a slight improvement over the conventional polychemotherapy scheme. The tumor microenvironment plays a crucial role in the pathogenesis of osteosarcoma by controlling the tumor growth, the metastatic process
However, the most recent clinical trials show a slight improvement over the conventional polychemotherapy scheme. The tumor microe
Acquired resistance to cancer immunotherapy.
Draghi A, Chamberlain CA, Furness A, Donia M. Draghi A, et al. Semin Immunopathol. 2019 Jan;41(1):31-40. doi: 10.1007/s00281-018-0692-y. Epub 2018 Jul 2. Semin Immunopathol. 2019. PMID: 29968044 Review.
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance.
Khalaf K, Hana D, Chou JT, Singh C, Mackiewicz A, Kaczmarek M. Khalaf K, et al. Front Immunol. 2021 May 27;12:656364. doi: 10.3389/fimmu.2021.656364. eCollection 2021. Front Immunol. 2021. PMID: 34122412 Free PMC article. Review.
The tumor microenvironment (TME) is a complex and ever-changing "rogue organ" composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM). ...
The tumor microenvironment (TME) is a complex and ever-changing "rogue organ" composed of its own blood supply, lymphatic and …
1,104,190 results
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