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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1961 1
1963 2
1964 2
1973 1
1974 1
1981 2
1982 1
1989 4
1991 2
1992 4
1993 9
1994 346
1995 780
1996 795
1997 827
1998 882
1999 822
2000 848
2001 1020
2002 1089
2003 1147
2004 1196
2005 1387
2006 1508
2007 1731
2008 1687
2009 1722
2010 1775
2011 1979
2012 2084
2013 1989
2014 2134
2015 2241
2016 2300
2017 2559
2018 2672
2019 1393
2020 24
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35,574 results
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Page 1
Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches.
Wu Q, et al. Cancer Lett 2014 - Review. PMID 24657660
Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. ...The challenges for the clinical detection of MDR will be to find new biomarkers and to determine new evaluation systems before the drug resistance emerges....
Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and …
The effect of medicinal plants on multiple drug resistance through autophagy: A review of in vitro studies.
Sameiyan E, et al. Eur J Pharmacol 2019 - Review. PMID 30965056
Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumor and cancer recurrence. ...It can cause MDR to become more difficult or make resistant cancer cells more susceptible to chemotherapeutic agents. A number of natural products have been introduced to drug discovery for many years. ...
Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to refractory tumor and cancer recurrence. . …
Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics.
Wijdeven RH, et al. Drug Resist Updat 2016 - Review. PMID 27620955
Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug resistance arising in the tumor. ...Over the years, multiple drug resistance mechanisms have been identified that enable tumors to cope with the damage instigated by a specific drug or group of anti-tumor agents. ...
Efficacy of chemotherapy in the treatment of distinct malignancies is often hampered by drug resistance arising in the tumor. …
Colon cancer: cancer stem cells markers, drug resistance and treatment.
Kozovska Z, et al. Biomed Pharmacother 2014 - Review. PMID 25458789
Tumours and relapsing tumours after therapy are drived by subpopulations of tumour cells with aggressive phenotype resistant to chemotherapeutics. ...The review provides a detailed overview of resistance of colon cancer cells and discusses how the presence of CSC markers can influence therapy and prognosis of patients....
Tumours and relapsing tumours after therapy are drived by subpopulations of tumour cells with aggressive phenotype resistant to chemo …
Bacteriophage for Mitigation of Multiple Drug Resistant Biofilm Forming Pathogens.
Kaistha SD and Umrao PD. Recent Pat Biotechnol 2016 - Review. PMID 27652612
OBJECTIVE: This review focuses on the development of bacteriophages as means of disrupting biofilm forming pathogens and hence mitigation of multiple drug resistant organisms. ...CONCLUSION: Phages are a promising alternative therapy for the control of multiple drug resistant (MDR) pathogens. Several phage (indigenous and engineered)/ phage products are currently being patented and developed as commercial biological control agents....
OBJECTIVE: This review focuses on the development of bacteriophages as means of disrupting biofilm forming pathogens and hence mitigation of …
Multiple resistance to carcinogens and xenobiotics: P-glycoproteins as universal detoxifiers.
Efferth T and Volm M. Arch Toxicol 2017 - Review. PMID 28175954
Their specific expression in diverse biological contexts cause different phenotypes: (1) multidrug resistance (MDR) and thus failure of cancer chemotherapy, (2) avoidance of accumulation of carcinogens and prevention of carcinogenesis in healthy tissues, (3) absorption, distribution, metabolization and excretion (ADME) of pharmacological drugs in human patients, (4) protection from environmental toxins in aquatic organisms (multi-xenobiotic resistance, MXR). ...
Their specific expression in diverse biological contexts cause different phenotypes: (1) multidrug resistance (MDR) and thus failure …
Research Progress in Reversal of Tumor Multi-drug Resistance via Natural Products.
Guo Q, et al. Anticancer Agents Med Chem 2017 - Review. PMID 29034843
Multidrug resistance limits the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug resistance is caused by numerous factors including changes in ATP-binding cassette transporters, target proteins, detoxification, deoxyribonucleic acid repair, drug metabolic enzymes, and signal pathways of apoptosis. ...Because natural products often have few adverse reactions and less drug resistance, the antitumor activities of natural products have attracted extensive research. ...
Multidrug resistance limits the treatment effects of antitumor drugs, and is the main cause of chemotherapy failure. Multidrug res
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