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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 6
2001 1
2003 59
2004 117
2005 151
2006 228
2007 347
2008 435
2009 474
2010 609
2011 679
2012 695
2013 779
2014 931
2015 1076
2016 1203
2017 1249
2018 1379
2019 686
2020 8
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9,725 results
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Page 1
Understanding Cancer Drug Resistance by Developing and Studying Resistant Cell Line Models.
Xavier CP, et al. Curr Cancer Drug Targets 2016 - Review. PMID 26563882
Indeed, the identification of novel therapeutic targets to overcome cancer drug resistance remains one of the major challenges in drug discovery and development. ...In addition, this review highlights the most frequent drug resistance mechanisms found in cancer cells....
Indeed, the identification of novel therapeutic targets to overcome cancer drug resistance remains one of the major challenges …
Modulating ROS to overcome multidrug resistance in cancer.
Cui Q, et al. Drug Resist Updat 2018 - Review. PMID 30471641
ROS in cancer cells play a central role in regulating and inducing apoptosis, thereby modulating cancer cells proliferation, survival and drug resistance. ...In the current review, we discuss the critical and targetable redox-regulating enzymes, including mitochondrial electron transport chain (ETC) complexes, NADPH oxidases (NOXs), enzymes related to glutathione metabolism, glutamate/cystine antiporter xCT, thioredoxin reductases (TrxRs), nuclear factor erythroid 2-related factor 2 (Nrf2), and their roles in regulating cellular ROS levels, drug resistance as well as their clinical significance. ...
ROS in cancer cells play a central role in regulating and inducing apoptosis, thereby modulating cancer cells proliferation, survival and …
Cisplatin resistance and opportunities for precision medicine.
Amable L. Pharmacol Res 2016 - Review. PMID 26804248
Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. ...
Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occ …
Dual Role of Mitophagy in Cancer Drug Resistance.
Yan C and Li TS. Anticancer Res 2018 - Review. PMID 29374684
The effectiveness of chemotherapy is largely limited by drug resistance. In the past few decades, modulation of anticancer drug resistance plays little role in benefit of clinical outcomes due to complex drug resistance mechanisms. ...Therefore, induction and inhibition of mitophagy in cancer drug resistance are controversial. In this review, we summarize current knowledge on the dual role of mitophagy in cancer drug resistance....
The effectiveness of chemotherapy is largely limited by drug resistance. In the past few decades, modulation of anticancer …
Natural products to prevent drug resistance in cancer chemotherapy: a review.
Yuan R, et al. Ann N Y Acad Sci 2017 - Review. PMID 28891091
Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against drug resistance. ...In this concise review, we summarize two strategies using natural products against drug resistance....
Fortunately, natural products with diverse chemical structures and pharmacological effects serve as effective substances against d
State-of-the-art strategies for targeting the DNA damage response in cancer
Pilié PG, et al. Nat Rev Clin Oncol 2019 - Review. PMID 30356138
Efforts to optimize these therapies are ongoing across a range of cancers, involving the development of predictive biomarker assays of responsiveness (beyond BRCA mutations), assessment of the mechanisms underlying intrinsic and acquired resistance, and evaluation of rational, tolerable combinations with standard-of-care treatments (such as chemotherapeutics and radiation), novel molecularly targeted agents and immune-checkpoint inhibitors. ...
Efforts to optimize these therapies are ongoing across a range of cancers, involving the development of predictive biomarker assays of respo …
Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches.
Hu X and Zhang Z. Trends Genet 2016 - Review. PMID 26689126
Diverse mechanisms, such as secondary mutations, oncogene bypass, and epigenetic alterations, can all lead to drug resistance, and the number of known involved genes is growing rapidly, thus providing many possibilities to overcome resistance. ...In this review, we briefly highlight the major drug-resistance mechanisms known today, and then focus primarily on the technological approaches leading to the advancement of this field....
Diverse mechanisms, such as secondary mutations, oncogene bypass, and epigenetic alterations, can all lead to drug resistance, …
Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment.
Bosc C, et al. Cell Metab 2017 - Review. PMID 29117545 Free article.
Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. ...
Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. ...
Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer.
Murtuza A, et al. Cancer Res 2019 - Review. PMID 30718357
Drug development has been breathtaking in this space with other third-generation compounds at various stages of development: rociletinib (CO-1686), olmutinib (HM61713), nazartinib (EGF816), naquotinib (ASP8273), mavelertinib (PF-0647775), and AC0010. ...The expansion of combinatorial therapies is a direction forward targeting minimal residual disease and bypass pathways early based on projected resistance....
Drug development has been breathtaking in this space with other third-generation compounds at various stages of development: rocileti
Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
Vallette FM, et al. Biochem Pharmacol 2019 - Review. PMID 30414937 Free article.
It is becoming increasingly clear that resistance is associated with the heterogeneity of cancer cells or micro-organisms and that multiple mechanisms underlie the emergence of drug-resistant subpopulations. Recently, it has been suggested that a subpopulation of drug tolerant cells present in cancer populations and called "persisters" play a major role in this resistance. ...
It is becoming increasingly clear that resistance is associated with the heterogeneity of cancer cells or micro-organisms and that mu …
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