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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 7
1948 7
1949 2
1950 10
1951 14
1952 14
1953 13
1954 10
1955 9
1956 10
1957 9
1958 7
1959 12
1960 10
1961 21
1962 18
1963 10
1964 16
1965 10
1966 13
1967 15
1968 8
1969 1
1970 11
1971 43
1972 63
1973 623
1974 1323
1975 1426
1976 1511
1977 1578
1978 1996
1979 2026
1980 2155
1981 2291
1982 2576
1983 2914
1984 3607
1985 3967
1986 4078
1987 4061
1988 4398
1989 4822
1990 5147
1991 4956
1992 5155
1993 5403
1994 5567
1995 5964
1996 6251
1997 6246
1998 6939
1999 7181
2000 7866
2001 8406
2002 9498
2003 10587
2004 10890
2005 11504
2006 11894
2007 11975
2008 12659
2009 12995
2010 14029
2011 13882
2012 13891
2013 13947
2014 14332
2015 14704
2016 13727
2017 12980
2018 12107
2019 5655
2020 162
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319,328 results
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Page 1
Drug combination studies and their synergy quantification using the Chou-Talalay method.
Chou TC. Cancer Res 2010. PMID 20068163 Free article.
This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination studies, in terms of experimental design, data acquisition, data interpretation, and computerized simulation. ...The resulting combination index (CI) theorem of Chou-Talalay offers quantitative definition for additive effect (CI = 1), synergism (CI < 1), and antagonism (CI > 1) in drug combinations. ...
This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination stu …
Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis.
Lajoie AC, et al. Lancet Respir Med 2016 - Review. PMID 26935844
Combined therapy was associated with significant risk reduction for clinical worsening compared with monotherapy (combined therapy 17% [332 of 1940 patients] vs monotherapy 28% [517 of 1862 patients], risk ratio [RR] 0·65 [95% CI 0·58-0·72], p<0·00001). ...Because many patients still had clinical worsening with combination therapy, identification of innovative therapeutic targets for PAH is thus urgently needed. ...
Combined therapy was associated with significant risk reduction for clinical worsening compared with monotherapy (combined therapy
Combination drug therapy for the treatment of status epilepticus.
Wang X, et al. Expert Rev Neurother 2015 - Review. PMID 26035623
In light of the diverse etiology and complex pathogenesis of SE, combination drug therapy for SE might be more conducive for the treatment of all patients because the combined use of drugs can produce synergistic effects via different mechanisms. This review summarizes combination drug therapies used for SE in animal experiments and clinical practice, the potential advantages of combination drug therapy and specific combination drug therapies using different antiepileptic drugs. ...
In light of the diverse etiology and complex pathogenesis of SE, combination drug therapy for SE might be more conducive for t …
Combination Glucose-Lowering Therapy Plans in T2DM: Case-Based Considerations.
Blonde L, et al. Adv Ther 2018 - Review. PMID 29777519
Metformin (if well tolerated and not contraindicated) is the initial pharmacologic choice for most patients; selection of another antihyperglycemic agent to the regimen will depend on the presence of atherosclerotic cardiovascular disease and other patient-specific factors (e.g., age, known duration of T2DM, history of or risk for hypoglycemia and/or adverse consequences from hypoglycemia, other comorbidities, and available resources), along with drug-specific factors (e.g., risk for hypoglycemia, potential effects on weight, drug adverse event profiles, and cost). Combination therapy may be administered as a multi-pill regimen, a single-pill combination (i.e., fixed-dose combination oral therapy), or as a combination of oral and/or injectable therapies. ...
Metformin (if well tolerated and not contraindicated) is the initial pharmacologic choice for most patients; selection of another antihyperg …
Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application.
Kerantzas CA and Jacobs WR. mBio 2017 - Review. PMID 28292983 Free PMC article.
Treatment of drug-susceptible tuberculosis requires combination antimicrobial therapy with a minimum of four antimicrobial agents applied over the course of 6 months. ...This observation is especially worth considering given the expanded role that combination therapy may play in combating the current rise in resistance to antimicrobial drugs....
Treatment of drug-susceptible tuberculosis requires combination antimicrobial therapy with a minimum of four antimicrobial age …
Effects of Ezetimibe-Statin Combination Therapy on Coronary Atherosclerosis in Acute Coronary Syndrome.
Hibi K, et al. Circ J 2018 - Clinical Trial. PMID 29212965 Free article.
The percent change in PV was -5.1% in the combination therapy group and -6.2% in the statin alone group (P=0.66), although both groups had reduction of PV compared with baseline (both P<0.01). ...CONCLUSIONS: In statin-naïve patients with ACS, combined therapy with ezetimibe and statin did not result in a significant change in coronary plaque regression or tissue component compared with statin alone. ...
The percent change in PV was -5.1% in the combination therapy group and -6.2% in the statin alone group (P=0.66), although both group …
Medication Adherence to Antihypertensive Triple-Combination Therapy Among Patients Enrolled in a Medicare Advantage Plan.
Wang X, et al. J Manag Care Spec Pharm 2019. PMID 31134857 Free article.
OBJECTIVE: To compare medication adherence rates among single-pill triple-combination therapy, free triple-combination therapy, and fixed-dose dual-combination therapy plus a third agent in hypertensive patients enrolled in a Medicare Advantage prescription drug plan using 2 adherence definitions. ...No significant difference was detected between single-pill triple-combination therapy in comparison with free-combination therapy. ...
OBJECTIVE: To compare medication adherence rates among single-pill triple-combination therapy, free triple-combination therapy
[Combination therapy for epilepsy].
Fröscher W and Rösche J. Fortschr Neurol Psychiatr 2013 - Review. PMID 22450761 German.
Use of Monotherapy is acknowledged as the standard anticonvulsant therapy although no more than about 65% of patients become seizure-free with a single antiepileptic drug. ...Monotherapy and combination therapy are not always contrary to each other; many anticonvulsants have different modes of action and are effectively a combination therapy in one drug. ...
Use of Monotherapy is acknowledged as the standard anticonvulsant therapy although no more than about 65% of patients become seizure- …
Network-based prediction of drug combinations.
Cheng F, et al. Nat Commun 2019. PMID 30867426 Free PMC article.
Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating multiple complex diseases. ...This finding allows us to identify and validate antihypertensive combinations, offering a generic, powerful network methodology to identify efficacious combination therapies in drug development....
Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating multiple c
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