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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 10
1992 22
1993 43
1994 62
1995 93
1996 112
1997 139
1998 137
1999 154
2000 179
2001 183
2002 207
2003 193
2004 204
2005 204
2006 225
2007 230
2008 220
2009 196
2010 236
2011 218
2012 250
2013 239
2014 238
2015 203
2016 206
2017 194
2018 199
2019 89
2020 0
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4,505 results
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Page 1
E2F Transcription Factors Control the Roller Coaster Ride of Cell Cycle Gene Expression.
Thurlings I and de Bruin A. Methods Mol Biol 2016 - Review. PMID 26254918
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 promoter and activate viral genes. ...The E2F transcription factors have been shown to be critical for the temporal expression of the oscillating cell cycle genes. ...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 promoter and activate viral …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer M and Müller GA. Crit Rev Biochem Mol Biol 2017 - Review. PMID 28799433
Expression of these groups of cell cycle-dependent genes is regulated by the RB pocket protein family, the E2F transcription factor family, and MuvB complexes together with B-MYB and FOXM1. Distinct combinations of these transcription factors promote the transcription of the two major groups of cell cycle genes that are maximally expressed either in S phase (G1/S) or in mitosis (G2/M). ...
Expression of these groups of cell cycle-dependent genes is regulated by the RB pocket protein family, the E2F transcription f …
The broken cycle: E2F dysfunction in cancer.
Kent LN and Leone G. Nat Rev Cancer 2019 - Review. PMID 31053804
The ultimate effectors of this axis are members of a family of eight distinct E2F genes encoding transcriptional activators and repressors. E2F transcriptional activity is tightly regulated throughout the cell cycle via transcriptional and translational regulation, post-translational modifications, protein degradation, binding to cofactors and subcellular localization. ...
The ultimate effectors of this axis are members of a family of eight distinct E2F genes encoding transcriptional activators an …
E2F transcription factors associated with up-regulated genes in glioblastoma.
Donaires FS, et al. Cancer Biomark 2017. PMID 27983535
OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in an attempt to point out molecular targets for therapy. ...
OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in …
Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair.
Wang L, et al. Proc Natl Acad Sci U S A 2018. PMID 29610335 Free PMC article.
Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes in Arabidopsis SNI1 binds to the activation domains of E2F transcription factors, the key regulators of cell cycle progression, and represses their transcriptional activities. ...Genetically, overexpression of SNI1 suppresses the phenotypes of E2F-overexpressing plants, and loss of E2F function fully suppresses the sni1 mutant, indicating that SNI1 is necessary and sufficient to inhibit E2Fs. ...
Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes …
E2F transcription factors and digestive system malignancies: how much do we know?
Evangelou K, et al. World J Gastroenterol 2014. PMID 25110451 Free PMC article.
The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. ...This complexity reflects the importance that these transcription factors have on a cell's fate. Thus, delineating the specific role for each E2F member in specific malignancies, although not easy, is a challenging and continuously pursued task, especially in view of potential E2F targeted therapies. ...
The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the ret …
Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci.
Shen Y, et al. J Cell Biochem 2018. PMID 28657656 Free PMC article.
Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcription factors. ...The data show that TFII-I interacts with E2F transcription factors. Furthermore, TFII-I, E2F4, and E2F6 interact with DNA-regulatory elements of several genes implicated in the regulation of the cell cycle, including DNMT1, HDAC1, CDKN1C, and CDC27. ...
Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcrip
Transcription factor compensation during mammary gland development in E2F knockout mice.
To B and Andrechek ER. PLoS One 2018. PMID 29617434 Free PMC article.
The E2F transcription factors control key elements of development, including mammary gland branching morphogenesis, with several E2Fs playing essential roles. ...Based on our computational findings and the fact that E2Fs share a common binding motif, we hypothesized that E2F transcription factors would compensate for each other during mammary development and function. ...
The E2F transcription factors control key elements of development, including mammary gland branching morphogenesis, wit …
E2F transcription factors and digestive system malignancies: how much do we know?
Xanthoulis A and Tiniakos DG. World J Gastroenterol 2013 - Review. PMID 23745020 Free PMC article.
E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. ...Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. ...
E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its indiv
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