Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 10
1992 22
1993 43
1994 62
1995 88
1996 109
1997 136
1998 125
1999 145
2000 152
2001 165
2002 190
2003 171
2004 178
2005 151
2006 92
2007 76
2008 63
2009 61
2010 58
2011 70
2012 57
2013 45
2014 57
2015 38
2016 46
2017 39
2018 29
2019 17
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

2,393 results
Results by year
Filters applied: . Clear all
Page 1
E2F Transcription Factors Control the Roller Coaster Ride of Cell Cycle Gene Expression.
Thurlings I and de Bruin A. Methods Mol Biol 2016 - Review. PMID 26254918
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 promoter and activate viral genes. ...The E2F transcription factors have been shown to be critical for the temporal expression of the oscillating cell cycle genes. ...
Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus E2 promoter and activate viral …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer M and Müller GA. Crit Rev Biochem Mol Biol 2017 - Review. PMID 28799433
Expression of these groups of cell cycle-dependent genes is regulated by the RB pocket protein family, the E2F transcription factor family, and MuvB complexes together with B-MYB and FOXM1. Distinct combinations of these transcription factors promote the transcription of the two major groups of cell cycle genes that are maximally expressed either in S phase (G1/S) or in mitosis (G2/M). ...
Expression of these groups of cell cycle-dependent genes is regulated by the RB pocket protein family, the E2F transcription f …
Non-canonical functions of the RB protein in cancer
Dick FA, et al. Nat Rev Cancer 2018 - Review. PMID 29692417 Free PMC article.
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. ...
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcrip
E2F transcription factors associated with up-regulated genes in glioblastoma.
Donaires FS, et al. Cancer Biomark 2017. PMID 27983535
OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in an attempt to point out molecular targets for therapy. ...
OBJECTIVE: We applied bioinformatics approaches to predict transcription factors (TF) that are deregulated in glioblastoma in …
Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair.
Wang L, et al. Proc Natl Acad Sci U S A 2018. PMID 29610335 Free PMC article.
Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes in Arabidopsis SNI1 binds to the activation domains of E2F transcription factors, the key regulators of cell cycle progression, and represses their transcriptional activities. ...Genetically, overexpression of SNI1 suppresses the phenotypes of E2F-overexpressing plants, and loss of E2F function fully suppresses the sni1 mutant, indicating that SNI1 is necessary and sufficient to inhibit E2Fs. ...
Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes …
The broken cycle: E2F dysfunction in cancer.
Kent LN and Leone G. Nat Rev Cancer 2019 - Review. PMID 31053804
The ultimate effectors of this axis are members of a family of eight distinct E2F genes encoding transcriptional activators and repressors. E2F transcriptional activity is tightly regulated throughout the cell cycle via transcriptional and translational regulation, post-translational modifications, protein degradation, binding to cofactors and subcellular localization. ...
The ultimate effectors of this axis are members of a family of eight distinct E2F genes encoding transcriptional activators an …
Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM.
Engeland K. Cell Death Differ 2018 - Review. PMID 29125603 Free PMC article.
The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become evident that p53-dependent repression is controlled by the p53-p21-DREAM-E2F/CHR pathway (p53-DREAM pathway). DREAM is a transcriptional repressor that binds to E2F or CHR promoter sites. Gene regulation and deregulation by DREAM shares many mechanistic characteristics with the retinoblastoma pRB tumor suppressor that acts through E2F elements. ...
The key mechanism of p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent years it has become ev …
E2F transcription factors and digestive system malignancies: how much do we know?
Evangelou K, et al. World J Gastroenterol 2014. PMID 25110451 Free PMC article.
The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. ...This complexity reflects the importance that these transcription factors have on a cell's fate. Thus, delineating the specific role for each E2F member in specific malignancies, although not easy, is a challenging and continuously pursued task, especially in view of potential E2F targeted therapies. ...
The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the ret …
Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci.
Shen Y, et al. J Cell Biochem 2018. PMID 28657656 Free PMC article.
Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcription factors. ...The data show that TFII-I interacts with E2F transcription factors. Furthermore, TFII-I, E2F4, and E2F6 interact with DNA-regulatory elements of several genes implicated in the regulation of the cell cycle, including DNMT1, HDAC1, CDKN1C, and CDC27. ...
Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcrip
E2F transcription factors and digestive system malignancies: how much do we know?
Xanthoulis A and Tiniakos DG. World J Gastroenterol 2013 - Review. PMID 23745020 Free PMC article.
E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. ...Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. ...
E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its indiv
2,393 results
Jump to page
Feedback