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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 14
1994 37
1995 40
1996 56
1997 62
1998 70
1999 69
2000 85
2001 93
2002 96
2003 114
2004 106
2005 93
2006 112
2007 125
2008 131
2009 113
2010 143
2011 120
2012 152
2013 155
2014 139
2015 114
2016 117
2017 109
2018 106
2019 44
2020 1
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2,387 results
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Page 1
E2F1 transcription factor and its impact on growth factor and cytokine signaling.
Ertosun MG, et al. Cytokine Growth Factor Rev 2016 - Review. PMID 26947516
E2F1 is a transcription factor involved in cell cycle regulation and apoptosis. The transactivation capacity of E2F1 is regulated by pRb. ...This review focuses on the relationship between E2F1 transcription factor and cytokines (IL-1, IL-2, IL-3, IL-6, TGF-beta, G-CSF, LIF), growth factors (EGF, KGF, VEGF, IGF, FGF, PDGF, HGF, NGF), and interferons (IFN-α, IFN-β and IFN-γ)....
E2F1 is a transcription factor involved in cell cycle regulation and apoptosis. The transactivation capacity of E2F1
Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer.
Wang T, et al. BMC Cancer 2017. PMID 29115924 Free PMC article.
Our previous reports showed that high expression of the transcription factor E2F1 was involved in the invasion and metastasis of SCLC, but the role of E2F1 in the process of EMT in SCLC is unknown. ...Next, the mechanism by which E2F1 promoted EMT was explored. Among the CDH1 related inhibitory transcriptional regulators ZEB1, ZEB2, SNAI1 and SNAI2, the expression of ZEB2 was the highest in SCLC tissue samples and was highly consistent with E2F1 expression. ...
Our previous reports showed that high expression of the transcription factor E2F1 was involved in the invasion and meta …
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Malaney P, et al. Cell Cycle 2018. PMID 29108454 Free PMC article.
PTEN-4A preferentially localized to the nucleus where it suppressed E2F1-mediated transcription of cell cycle genes. PTEN-4A physically interacted with the transcription factor E2F1 and associated with chromatin at gene promoters with E2F1 DNA-binding sites, a likely mechanism for its transcriptional suppression function. Deletion analysis revealed that the C2 domain of PTEN was indispensable for suppression of E2F1-mediated transcription. Further, we uncovered cancer-associated C2 domain mutant proteins that had lost their ability to suppress E2F1-mediated transcription, supporting the concept that these mutations are oncogenic in patients. ...
PTEN-4A preferentially localized to the nucleus where it suppressed E2F1-mediated transcription of cell cycle genes. PTEN-4A p …
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation.
Dubrez L. Int J Mol Sci 2017 - Review. PMID 29048367 Free PMC article.
E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. ...I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1's regulation....
E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradic
The Role of the Transcription Factor E2F1 in Hepatocellular Carcinoma.
Farra R, et al. Curr Drug Deliv 2017 - Review. PMID 27109336
In this regard, E2F1 may represent an interesting candidate. E2F1 is a transcription factor implicated in the regulation of many cellular processes including cell proliferation and apoptosis. Whereas the involvement of E2F1 in HCC has been recognized, its ability to act as a proliferative and/or apoptotic factor in HCC has not yet been clarified and, in this regard, an active debate is ongoing. ...
In this regard, E2F1 may represent an interesting candidate. E2F1 is a transcription factor implicated in the re …
[Effect of transcription factor E2F1 expression on the invasion of prostate cancer].
Bi XC, et al. Zhonghua Yi Xue Za Zhi 2017. PMID 29050152 Chinese.
Objective: To investigate the effect of transcription factor E2F1 on the invasion of prostate cancer and its clinical significance. Methods: A stable inhibition of E2F1 prostate cancer cell line PC3 was established. The E2F1 and relative invasion biomarker protein expression level of the transfected cells was detected by Western blot. ...
Objective: To investigate the effect of transcription factor E2F1 on the invasion of prostate cancer and its clinical s …
E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression.
Muthusamy S, et al. J Biol Chem 2015. PMID 26527687 Free PMC article.
Protein O-GlcNAcylation, which is controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), has emerged as an important posttranslational modification that may factor in multiple diseases. ...Here, we used a reporter-based assay to analyze minimal promoters and leveraged in silico modeling to nominate several candidate transcription factor binding sites in both Ogt (i.e. the gene for OGT protein) and Mgea5 (i.e. the gene for OGA protein). ...
Protein O-GlcNAcylation, which is controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), has emerged as an important posttranslatio …
[Regulation mechanism of E2F1 transcription factor on M2 macrophages in full-thickness skin defect wounds of mice].
Xiao H, et al. Zhonghua Shao Shang Za Zhi 2019. PMID 30798576 Chinese.
Objective: To explore the regulatory mechanism of E2F1 transcription factor on M2 macrophages in full-thickness skin defect wounds of mice. ...On PID 7, detection of the wound tissue of mice in wild-type group showed that PPAR-γ had unidirectional effect on E2F1. Conclusions: E2F1 transcription factor affects the polarization of M2 macrophages by inhibiting the expression of PPAR-γ, thereby inhibiting the healing process of full-thickness skin defect wounds in mice....
Objective: To explore the regulatory mechanism of E2F1 transcription factor on M2 macrophages in full-thickness skin de …
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
Zeng H, et al. Cancer Cell 2018. PMID 29990501 Free PMC article.
Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage-restricted transcription factor, BRN2, is downstream of CDKN2A and directly regulated by E2F1. ...
Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage-restricte …
MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance.
Lai X, et al. Theranostics 2018. PMID 29464002 Free PMC article.
Sequence and structural information were used to identify potential miRNA pairs that can form tertiary structures with E2F1 mRNA. ...A mathematical model simulating the E2F1 regulation by the cooperative miRNAs predicted enhanced E2F1 repression, a feature that was verified by in vitro experiments. ...
Sequence and structural information were used to identify potential miRNA pairs that can form tertiary structures with E2F1 mRNA. ... …
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