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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 13
2006 41
2007 47
2008 58
2009 41
2010 59
2011 52
2012 60
2013 58
2014 54
2015 47
2016 45
2017 39
2018 48
2019 20
2020 0
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596 results
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Page 1
E2F1 transcription factor and its impact on growth factor and cytokine signaling.
Ertosun MG, et al. Cytokine Growth Factor Rev 2016 - Review. PMID 26947516
E2F1 is a transcription factor involved in cell cycle regulation and apoptosis. The transactivation capacity of E2F1 is regulated by pRb. ...This review focuses on the relationship between E2F1 transcription factor and cytokines (IL-1, IL-2, IL-3, IL-6, TGF-beta, G-CSF, LIF), growth factors (EGF, KGF, VEGF, IGF, FGF, PDGF, HGF, NGF), and interferons (IFN-α, IFN-β and IFN-γ)....
E2F1 is a transcription factor involved in cell cycle regulation and apoptosis. The transactivation capacity of E2F1
Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer.
Wang T, et al. BMC Cancer 2017. PMID 29115924 Free PMC article.
Our previous reports showed that high expression of the transcription factor E2F1 was involved in the invasion and metastasis of SCLC, but the role of E2F1 in the process of EMT in SCLC is unknown. ...Next, the mechanism by which E2F1 promoted EMT was explored. Among the CDH1 related inhibitory transcriptional regulators ZEB1, ZEB2, SNAI1 and SNAI2, the expression of ZEB2 was the highest in SCLC tissue samples and was highly consistent with E2F1 expression. ...
Our previous reports showed that high expression of the transcription factor E2F1 was involved in the invasion and meta …
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation.
Dubrez L. Int J Mol Sci 2017 - Review. PMID 29048367 Free PMC article.
E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. ...I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1's regulation....
E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradic
The Role of the Transcription Factor E2F1 in Hepatocellular Carcinoma.
Farra R, et al. Curr Drug Deliv 2017 - Review. PMID 27109336
In this regard, E2F1 may represent an interesting candidate. E2F1 is a transcription factor implicated in the regulation of many cellular processes including cell proliferation and apoptosis. Whereas the involvement of E2F1 in HCC has been recognized, its ability to act as a proliferative and/or apoptotic factor in HCC has not yet been clarified and, in this regard, an active debate is ongoing. ...
In this regard, E2F1 may represent an interesting candidate. E2F1 is a transcription factor implicated in the re …
[Effect of transcription factor E2F1 expression on the invasion of prostate cancer].
Bi XC, et al. Zhonghua Yi Xue Za Zhi 2017. PMID 29050152 Chinese.
Objective: To investigate the effect of transcription factor E2F1 on the invasion of prostate cancer and its clinical significance. Methods: A stable inhibition of E2F1 prostate cancer cell line PC3 was established. The E2F1 and relative invasion biomarker protein expression level of the transfected cells was detected by Western blot. ...
Objective: To investigate the effect of transcription factor E2F1 on the invasion of prostate cancer and its clinical s …
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Malaney P, et al. Cell Cycle 2018. PMID 29108454 Free PMC article.
PTEN-4A preferentially localized to the nucleus where it suppressed E2F1-mediated transcription of cell cycle genes. PTEN-4A physically interacted with the transcription factor E2F1 and associated with chromatin at gene promoters with E2F1 DNA-binding sites, a likely mechanism for its transcriptional suppression function. Deletion analysis revealed that the C2 domain of PTEN was indispensable for suppression of E2F1-mediated transcription. Further, we uncovered cancer-associated C2 domain mutant proteins that had lost their ability to suppress E2F1-mediated transcription, supporting the concept that these mutations are oncogenic in patients. ...
PTEN-4A preferentially localized to the nucleus where it suppressed E2F1-mediated transcription of cell cycle genes. PTEN-4A p …
E2F transcription factor-1 regulates oxidative metabolism.
Blanchet E, et al. Nat Cell Biol 2011. PMID 21841792 Free PMC article.
Conversely, cell growth and proliferation require increased glycolytic and decreased oxidative metabolism levels. E2F transcription factors regulate both proliferative and metabolic genes. ...Thus, E2F1 represents a metabolic switch from oxidative to glycolytic metabolism that responds to stressful conditions....
Conversely, cell growth and proliferation require increased glycolytic and decreased oxidative metabolism levels. E2F transcriptio
MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance.
Lai X, et al. Theranostics 2018. PMID 29464002 Free PMC article.
Sequence and structural information were used to identify potential miRNA pairs that can form tertiary structures with E2F1 mRNA. ...A mathematical model simulating the E2F1 regulation by the cooperative miRNAs predicted enhanced E2F1 repression, a feature that was verified by in vitro experiments. ...
Sequence and structural information were used to identify potential miRNA pairs that can form tertiary structures with E2F1 mRNA. ... …
E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells.
Xu S, et al. Circ Res 2018. PMID 29358228 Free PMC article.
We have previously reported that the E2F transcription factor 1 (E2F1) is a repressor of revascularization after ischemic injury. OBJECTIVE: We sought to define the role of E2F1 in the regulation of BM PC function. METHODS AND RESULTS: Ablation of E2F1 (E2F1 deficient) in mouse BM PCs increases oxidative metabolism and reduces lactate production, resulting in enhanced endothelial differentiation. ...
We have previously reported that the E2F transcription factor 1 (E2F1) is a repressor of revascularization after ischem …
PARP-1 regulates DNA repair factor availability.
Schiewer MJ, et al. EMBO Mol Med 2018. PMID 30467127 Free PMC article.
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. ...Mechanistic investigation revealed that active PARP-1 served to enhance E2F1 transcription factor activity, and specifically promoted E2F1-mediated induction of DNA repair factors involved in homologous recombination (HR). ...
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the contex …
596 results
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