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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1797 2
1799 2
1801 2
1802 1
1803 2
1804 4
1809 2
1810 2
1811 4
1814 1
1816 2
1817 1
1819 1
1820 2
1823 2
1824 1
1827 1
1828 2
1829 1
1830 3
1831 2
1834 2
1835 1
1836 3
1837 3
1838 3
1839 4
1840 5
1841 1
1842 9
1843 4
1844 4
1845 7
1846 5
1847 6
1848 3
1849 2
1850 1
1851 2
1852 7
1853 3
1854 6
1855 2
1856 3
1857 4
1858 2
1859 2
1860 3
1861 3
1862 1
1863 1
1864 3
1866 4
1867 3
1868 6
1869 7
1870 3
1871 2
1872 10
1873 5
1874 9
1875 6
1876 4
1877 3
1878 1
1879 3
1880 5
1881 12
1882 20
1883 8
1884 14
1885 8
1886 8
1887 7
1888 3
1889 11
1890 19
1891 21
1892 16
1893 10
1894 4
1895 8
1896 8
1897 14
1898 14
1899 10
1900 27
1901 14
1902 8
1903 13
1904 15
1905 22
1906 13
1907 18
1908 23
1909 23
1910 17
1911 25
1912 31
1913 31
1914 26
1915 47
1916 41
1917 39
1918 40
1919 33
1920 33
1921 47
1922 42
1923 47
1924 51
1925 61
1926 56
1927 59
1928 60
1929 53
1930 55
1931 58
1932 44
1933 37
1934 49
1935 55
1936 64
1937 45
1938 58
1939 46
1940 51
1941 46
1942 30
1943 47
1944 38
1945 1409
1946 4892
1947 5950
1948 5154
1949 4621
1950 7297
1951 8563
1952 8466
1953 9214
1954 9724
1955 9859
1956 10389
1957 11061
1958 11273
1959 11841
1960 12589
1961 13674
1962 14362
1963 18679
1964 24015
1965 33913
1966 42212
1967 47168
1968 51837
1969 56521
1970 57281
1971 61031
1972 65224
1973 67813
1974 69930
1975 72174
1976 70111
1977 71123
1978 73453
1979 78088
1980 80815
1981 81829
1982 84759
1983 87295
1984 90611
1985 92858
1986 96246
1987 98372
1988 102807
1989 107489
1990 111361
1991 111960
1992 112799
1993 114935
1994 118673
1995 120358
1996 121243
1997 123111
1998 126375
1999 128052
2000 135443
2001 138514
2002 143439
2003 149335
2004 158302
2005 170055
2006 182485
2007 188519
2008 196367
2009 203855
2010 214868
2011 224231
2012 235268
2013 243278
2014 245143
2015 246390
2016 241980
2017 239490
2018 243369
2019 247329
2020 256449
2021 252263
2022 214390
2023 200592
2024 252442
2025 68090

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7,939,607 results

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Page 1
Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer.
Wu SG, Shih JY. Wu SG, et al. Mol Cancer. 2018 Feb 19;17(1):38. doi: 10.1186/s12943-018-0777-1. Mol Cancer. 2018. PMID: 29455650 Free PMC article. Review.
Activating mutations of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) are a favorable predictive factor for EGFR tyrosine kinase inhibitors (TKIs) treatment. ...EGFR TKIs improve response rates, time to progression, and overall …
Activating mutations of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) are a favorable predictive fact …
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Vander Heiden MG, Cantley LC, Thompson CB. Vander Heiden MG, et al. Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809. Science. 2009. PMID: 19460998 Free PMC article. Review.
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg eff …
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the en …
Microglial M1/M2 polarization and metabolic states.
Orihuela R, McPherson CA, Harry GJ. Orihuela R, et al. Br J Pharmacol. 2016 Feb;173(4):649-65. doi: 10.1111/bph.13139. Epub 2015 May 11. Br J Pharmacol. 2016. PMID: 25800044 Free PMC article. Review.
Studies using peripheral immune cells demonstrate that polarization to an M1 phenotype is often accompanied by a shift in cells from oxidative phosphorylation to aerobic glycolysis for energy production. More recently, the link between polarization and …
Studies using peripheral immune cells demonstrate that polarization to an M1 phenotype is often accompanied by a shift in cells from oxid …
New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages.
Batista-Gonzalez A, Vidal R, Criollo A, Carreño LJ. Batista-Gonzalez A, et al. Front Immunol. 2020 Jan 10;10:2993. doi: 10.3389/fimmu.2019.02993. eCollection 2019. Front Immunol. 2020. PMID: 31998297 Free PMC article. Review.
Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glycolysis and fatty acid biosynthesis. Glycolysis is a fast way of producing ATP, and fatty acids serve as precursors for the synthesis of i …
Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glyco …
Ferritinophagy mediates adaptive resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer.
Wang H, Hu Q, Chen Y, Huang X, Feng Y, Shi Y, Li R, Yin X, Song X, Liang Y, Zhang T, Xu L, Dong G, Jiang F. Wang H, et al. Nat Commun. 2024 May 17;15(1):4195. doi: 10.1038/s41467-024-48433-8. Nat Commun. 2024. PMID: 38760351 Free PMC article.
Osimertinib (Osi) is a widely used epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). However, the emergence of resistance is inevitable, partly due to the gradual evolution of adaptive resistant cells during initial treatment. ...Metabolomics analysis …
Osimertinib (Osi) is a widely used epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). However, the emergence of r …
EGFR signaling pathway as therapeutic target in human cancers.
Levantini E, Maroni G, Del Re M, Tenen DG. Levantini E, et al. Semin Cancer Biol. 2022 Oct;85:253-275. doi: 10.1016/j.semcancer.2022.04.002. Epub 2022 Apr 12. Semin Cancer Biol. 2022. PMID: 35427766 Review.
Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand orchestrator of epithelial transformation, and hence one of the most world-wide studied tyrosine kinase …
Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance of epithelial tissues. However, when EGFR signal …
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer.
Fontana F, Giannitti G, Marchesi S, Limonta P. Fontana F, et al. Int J Biol Sci. 2024 May 27;20(8):3113-3125. doi: 10.7150/ijbs.89942. eCollection 2024. Int J Biol Sci. 2024. PMID: 38904014 Free PMC article. Review.
In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic glycolysis or Warburg effect, by phosphorylating different nutrient transporters and metabolic enzymes, such as GLUT1, HK2, PFKB3/4 and PK …
In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic gl …
Mitochondrial transfer in tunneling nanotubes-a new target for cancer therapy.
Guan F, Wu X, Zhou J, Lin Y, He Y, Fan C, Zeng Z, Xiong W. Guan F, et al. J Exp Clin Cancer Res. 2024 May 21;43(1):147. doi: 10.1186/s13046-024-03069-w. J Exp Clin Cancer Res. 2024. PMID: 38769583 Free PMC article. Review.
A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from the tricarboxylic acid cycle to …
A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tum …
Molecular Mechanisms and Targeted Therapies Including Immunotherapy for Non-Small Cell Lung Cancer.
Nagano T, Tachihara M, Nishimura Y. Nagano T, et al. Curr Cancer Drug Targets. 2019;19(8):595-630. doi: 10.2174/1568009619666181210114559. Curr Cancer Drug Targets. 2019. PMID: 30526458 Review.
Vigorous efforts of clinicians and researchers have revealed that lung cancer develops through the activating mutations of many driver genes including the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), v-Raf murine sarco …
Vigorous efforts of clinicians and researchers have revealed that lung cancer develops through the activating mutations of many driver genes …
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.
Wei Y, Miao Q, Zhang Q, Mao S, Li M, Xu X, Xia X, Wei K, Fan Y, Zheng X, Fang Y, Mei M, Zhang Q, Ding J, Fan Y, Lu M, Hu G. Wei Y, et al. Nat Neurosci. 2023 Dec;26(12):2081-2089. doi: 10.1038/s41593-023-01476-4. Epub 2023 Nov 23. Nat Neurosci. 2023. PMID: 37996529
Here, we demonstrated that neuronal somata perform higher levels of aerobic glycolysis and lower levels of OXPHOS than terminals, both during basal and activated states. ...Deletion of Pkm2 in mice results in a switch from aerobic glycolysis to OXPHOS …
Here, we demonstrated that neuronal somata perform higher levels of aerobic glycolysis and lower levels of OXPHOS than termina …
7,939,607 results
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