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1999 13
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Laboratory enamel solubility reduction and fluoride uptake from enamelon dentifrice.
Schemehorn BR, et al. J Clin Dent 1999. PMID 10686852
The purpose of this study was to determine the bio-availability of fluoride from Enamelon Toothpaste (E), which simultaneously supplies fluoride, calcium and phosphate salts from a dual dispensing package. ...The laboratory results indicate that the calcium and phosphate salts delivered by the remineralizing Enamelon dentifrice increase the bioavailability of fluoride to substantially exceed that of the clinically proven standard dentifrice....
The purpose of this study was to determine the bio-availability of fluoride from Enamelon Toothpaste (E), which simultaneously suppli …
Comparison of the enamel solubility reduction from Various prescription and OTC fluoride toothpastes and gels
Schemehorn BR, et al. J Clin Dent 2014. PMID 26054180
The teeth sets were then exposed to the following treatments (diluted 1:3 parts in preheated [37 degrees C] distilled water): 5000 ppm F- ion, sodium fluoride (NaF) Rx dentifrice containing TCP; 5000 ppm F- ion, NaF Rx dentifrice; 900 ppm F- ion, NaF Rx paste with CPP-ACP; 1150 ppm F- ion, stannous fluoride (SnF2) OTC toothpaste delivering ACP Enamelon Toothpaste; and 970 ppm F- ion, SnF2 OTC gel delivering ACP (Enamelon Preventive Treatment Gel). ...The differences between all the products tested were statistically significant (p < 0.05), except for the Enamelon products that were not statistically different. ...
The teeth sets were then exposed to the following treatments (diluted 1:3 parts in preheated [37 degrees C] distilled water): 5000 ppm F- io …
Comparison of the incipient lesion enamel fluoride uptake from various prescription and OTC fluoride toothpastes and gels
Schemehorn BR, et al. J Clin Dent 2014. PMID 26054179
OBJECTIVE: The objective of this in vitro study was to compare the fluoride uptake into incipient enamel lesions of a novel 970 ppm F- ion SnF2 over-the-counter (OTC) gel (Enamelon Preventive Treatment Gel) and a novel 1150 ppm F- ion OTC toothpaste (Enamelon), each delivering amorphous calcium phosphate (ACP), to the uptake from two different prescription strength, 5000 ppm F- ion dentifrices containing tri-calcium phosphate (TCP) and a prescription 900 ppm F- ion paste containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). ...The treatments were performed using slurries of a negative control (water) and the following products applied to a set of sound enamel cores: 5000 ppm F- ion, sodium fluoride (NaF) prescription (Rx) dentifrice "A" containing TCP; 5000 ppm F- ion, NaF Rx dentifrice "B" containing TCP; 900 ppm F- ion, NaF Rx paste with CPP-ACP; 1150 ppm F- ion, NaF OTC toothpaste; 1150 ppm F- ion, stannous fluoride (SnF2) OTC toothpaste delivering ACP (Enamelon); 1100 ppm F- ion, SnF2 OTC toothpaste; and 970 ppm F- ion, SnF2 OTC gel delivering ACP (Enamelon Preventive Treatment Gel). ...
OBJECTIVE: The objective of this in vitro study was to compare the fluoride uptake into incipient enamel lesions of a novel 970 ppm F- ion S …
Enamel caries formation and lesion progression with a fluoride dentifrice and a calcium-phosphate containing fluoride dentifrice: a polarized light microscopic study
Hicks MJ and Flaitz CM. ASDC J Dent Child 2000. PMID 10736654
Mean lesion depths (polarized light, water imbibition) were as follows: 1) Lesion Initiation: Control 109 +/- 19 microns, Colgate Total 76 +/- 14 microns, Enamelon 63 +/- 17 microns; 2) First Lesion Progression: Control 164; +/- 24 microns, Colgate Total 124 +/- 22 microns, Enamelon 110 +/- 19 microns; 3) Second Lesion Progression: Control 235 +/- 23 microns; Colgate Total 172 +/- 27 microns, Enamelon 153 +/- 18 microns. ...Enamelon provided a further reduction in lesion depth for all periods when compared with Colgate Total (P > .05, ANOVA, DMR). ...
Mean lesion depths (polarized light, water imbibition) were as follows: 1) Lesion Initiation: Control 109 +/- 19 microns, Colgate Total 76 + …
Caries inhibition in rats by a remineralizing toothpaste
Grant LP, et al. J Clin Dent 1999. PMID 10686857
Both the Enamelon-like product and Crest Regular treatments resulted in lower total enamel caries scores than the placebo (p < 0.001). ...Therefore, the Enamelon-like product had superior caries inhibiting properties compared to Crest Regular at these tooth areas....

Both the Enamelon-like product and Crest Regular treatments resulted in lower total enamel caries scores than the placebo (p < 0.0

The in vitro demineralization potential of a sodium fluoride, calcium and phosphate ion-containing dentifrice under various experimental conditions
Kardos S, et al. J Clin Dent 1999. PMID 10686855
The objective of this study was to determine the demineralization prevention potential of a remineralizing dentifrice with fluoride (Enamelon), and an assured supply of calcium and phosphate ions on bovine enamel in a cyclic remin/demin regimen using various experimental conditions. ...The results of this study showed that Enamelon Toothpaste was generally more effective in preventing demineralization of enamel than the fluoride dentifrice at 0.5 and 1.5 hours, and the non-fluoride control dentifrice at all time measurements. ...
The objective of this study was to determine the demineralization prevention potential of a remineralizing dentifrice with fluoride (Enam
Clinical evaluation of the effect of a remineralizing toothpaste on dentinal sensitivity
Kaufman HW, et al. J Clin Dent 1999 - Clinical Trial. PMID 10686861
This study evaluated, in a double blind clinical trial, the effect of Enamelon, a dentifrice containing sodium fluoride, calcium salts and phosphate salts (calcium separated from the phosphate and fluoride by a plastic divider in the tube to prevent interaction) on dentinal hypersensitivity over an 8-week period. ...Based upon subjective anecdotal information, net numbers of sensitive teeth which became non-sensitive, and a logit analysis of the change in the proportion of sensitive teeth over the study time period, Enamelon was the most effective product, and the OTC control the least effective....
This study evaluated, in a double blind clinical trial, the effect of Enamelon, a dentifrice containing sodium fluoride, calcium salt …
Calcium phosphate-based remineralization systems: scientific evidence?
Reynolds EC. Aust Dent J 2008 - Review. PMID 18782374 Free article.
In recent times three calcium phosphate-based remineralization systems have been developed and are now commercially available: a casein phosphopeptide stabilized amorphous calcium phosphate (Recaldent (CPP-ACP), CASRN691364-49-5), an unstabilized amorphous calcium phosphate (ACP or Enamelon) and a bioactive glass containing calcium sodium phosphosilicate (NovaMin). ...The review has revealed that there is evidence for an anticariogenic efficacy of the Enamelon technology for root caries and for the Recaldent technology in significantly slowing the progression of coronal caries and promoting the regression of lesions in randomized, controlled clinical trials. ...
In recent times three calcium phosphate-based remineralization systems have been developed and are now commercially available: a casein phos …
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