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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 20
2004 66
2005 135
2006 129
2007 188
2008 225
2009 207
2010 182
2011 189
2012 271
2013 305
2014 287
2015 296
2016 309
2017 241
2018 254
2019 91
2020 0
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2,917 results
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Page 1
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard CJ. Neuropsychopharmacology 2018 - Review. PMID 28653665 Free PMC article.
The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistently support the hypothesis that endocannabinoid signaling is associated with increased consumption and storage of energy. ...Other conditions under which circulating endocannabinoids are altered include inflammation and pain. A second important role for endocannabinoid signaling is to restore homeostasis following stress. ...
The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistentl …
Endocannabinoids--at the crossroads between the gut microbiota and host metabolism.
Cani PD, et al. Nat Rev Endocrinol 2016 - Review. PMID 26678807
In this Review, we briefly define the gut microbiota as well as the endocannabinoid system and associated bioactive lipids. We discuss existing literature regarding interactions between gut microorganisms and the endocannabinoid system, focusing specifically on the triad of adipose tissue, gut bacteria and the endocannabinoid system in the context of obesity and the development of fat mass. We highlight gut-barrier function by discussing the role of specific factors considered to be putative 'gate keepers' or 'gate openers', and their role in the gut microbiota-endocannabinoid system axis. ...
In this Review, we briefly define the gut microbiota as well as the endocannabinoid system and associated bioactive lipids. We discus …
Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders.
Iannotti FA, et al. Prog Lipid Res 2016 - Review. PMID 26965148
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors (GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid ligands of such receptors (also known as the "endocannabinoids"), anandamide and 2-arachidonoyl-glycerol. ...Indeed, following the discovery of the endocannabinoids, endocannabinoid-related lipid mediators, which often share the same metabolic pathways of the endocannabinoids, have also been identified or rediscovered. ...
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors (GPCRs), the cannabinoid CB1 and CB2 receptors, and t …
Early phytocannabinoid chemistry to endocannabinoids and beyond.
Mechoulam R, et al. Nat Rev Neurosci 2014 - Review. PMID 25315390
It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders....
It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endo
Endocannabinoid System: A Multi-Facet Therapeutic Target.
Kaur R, et al. Curr Clin Pharmacol 2016 - Review. PMID 27086601
The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions. ...In order to successfully exploit the therapeutic potential of endocannabinoid system, it is imperative to further characterize the endocannabinoid system in terms of identification of the exact cellular location of cannabinoid receptors and their role as "protective" and "disease inducing substance", time-dependent changes in the expression of cannabinoid receptors....
The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that …
Polyunsaturated fatty acids and endocannabinoids in health and disease.
Freitas HR, et al. Nutr Neurosci 2018 - Review. PMID 28686542
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) synthesized from membrane phospholipids and used as a precursor for endocannabinoids (ECs). ...Cloning of cannabinoid receptors in the 90s and the identification of the endogenous mediators arachidonylethanolamide (anandamide, AEA) and 2-arachidonyglycerol (2-AG), led to the characterization of the endocannabinoid system (ECS), together with their metabolizing enzymes and membrane transporters. ...
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid, EPA) or of omega …
Endocannabinoid system in neurodegenerative disorders.
Basavarajappa BS, et al. J Neurochem 2017 - Review. PMID 28608560 Free PMC article.
The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enzymes that catabolize these compounds, has been shown to contribute to the development of NDDs in several animal models and human studies. In this review, we discuss the functions of the endocannabinoid system in NDDs and converse the therapeutic efficacy of targeting the endocannabinoid system to rescue NDDs....
The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enz …
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.
Zou S and Kumar U. Int J Mol Sci 2018 - Review. PMID 29533978 Free PMC article.
In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. ...
In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, …
Marijuana Use in Pregnancy and While Breastfeeding
Metz TD and Borgelt LM. Obstet Gynecol 2018 - Review. PMID 30234728 Free PMC article.
The harms are biologically plausible given the role of the endocannabinoid system in pregnancy implantation, placentation, and fetal neurologic development. ...
The harms are biologically plausible given the role of the endocannabinoid system in pregnancy implantation, placentation, and fetal …
Endocannabinoids in arthritis: current views and perspective.
Barrie N, et al. Int J Rheum Dis 2017 - Review. PMID 28736968
This synopsis reviews the various components of the endocannabinoid system in health and disease and their potential as therapeutic targets....
This synopsis reviews the various components of the endocannabinoid system in health and disease and their potential as therapeutic t …
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