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Year Number of Results
2011 4
2012 110
2013 172
2014 171
2015 205
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2017 159
2018 161
2019 58
2020 1
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Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders.
Iannotti FA, et al. Prog Lipid Res 2016 - Review. PMID 26965148
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors (GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid ligands of such receptors (also known as the "endocannabinoids"), anandamide and 2-arachidonoyl-glycerol. ...Indeed, following the discovery of the endocannabinoids, endocannabinoid-related lipid mediators, which often share the same metabolic pathways of the endocannabinoids, have also been identified or rediscovered. ...
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors (GPCRs), the cannabinoid CB1 and CB2 receptors, and t …
Metabolism of endocannabinoids.
Biernacki M and Skrzydlewska E. Postepy Hig Med Dosw (Online) 2016 - Review. PMID 27516570
Endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors CB1, CB2, TRPV1 and GPR55 that are included in the endocannabinoid system of the animal organism. ...Through activation of receptors, endocannabinoids affect cellular metabolism and participate in the metabolic processes by receptor-independent pathways. ...
Endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors CB
Endocannabinoids--at the crossroads between the gut microbiota and host metabolism.
Cani PD, et al. Nat Rev Endocrinol 2016 - Review. PMID 26678807
Among the latest advances in the metabolism field, the discovery that gut microorganisms have a major role in host metabolism has revealed the possibility of a plethora of associations between gut bacteria and numerous diseases. ...In this Review, we briefly define the gut microbiota as well as the endocannabinoid system and associated bioactive lipids. We discuss existing literature regarding interactions between gut microorganisms and the endocannabinoid system, focusing specifically on the triad of adipose tissue, gut bacteria and the endocannabinoid system in the context of obesity and the development of fat mass. ...
Among the latest advances in the metabolism field, the discovery that gut microorganisms have a major role in host metabolism
Endocannabinoid system in neurodegenerative disorders.
Basavarajappa BS, et al. J Neurochem 2017 - Review. PMID 28608560 Free PMC article.
The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enzymes that catabolize these compounds, has been shown to contribute to the development of NDDs in several animal models and human studies. In this review, we discuss the functions of the endocannabinoid system in NDDs and converse the therapeutic efficacy of targeting the endocannabinoid system to rescue NDDs....
The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enz …
Endocannabinoid System: A Multi-Facet Therapeutic Target.
Kaur R, et al. Curr Clin Pharmacol 2016 - Review. PMID 27086601
The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that endocannabinoids has role in pathology of many disorders and they also serve "protective role" in many medical conditions. ...In order to successfully exploit the therapeutic potential of endocannabinoid system, it is imperative to further characterize the endocannabinoid system in terms of identification of the exact cellular location of cannabinoid receptors and their role as "protective" and "disease inducing substance", time-dependent changes in the expression of cannabinoid receptors....
The research of drugs acting on endocannabinoid system has seen many ups and downs in the recent past. Presently, it is known that …
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
Hillard CJ. Neuropsychopharmacology 2018 - Review. PMID 28653665 Free PMC article.
The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistently support the hypothesis that endocannabinoid signaling is associated with increased consumption and storage of energy. ...Other conditions under which circulating endocannabinoids are altered include inflammation and pain. A second important role for endocannabinoid signaling is to restore homeostasis following stress. ...
The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistentl …
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.
Zou S and Kumar U. Int J Mol Sci 2018 - Review. PMID 29533978 Free PMC article.
In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. ...
In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, …
Marijuana Use in Pregnancy and While Breastfeeding
Metz TD and Borgelt LM. Obstet Gynecol 2018 - Review. PMID 30234728 Free PMC article.
The harms are biologically plausible given the role of the endocannabinoid system in pregnancy implantation, placentation, and fetal neurologic development. ...
The harms are biologically plausible given the role of the endocannabinoid system in pregnancy implantation, placentation, and fetal …
Distribution of the Endocannabinoid System in the Central Nervous System.
Hu SS and Mackie K. Handb Exp Pharmacol 2015 - Review. PMID 26408158
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degrade endocannabinoids, and the receptors that transduce the effects of endocannabinoids. Much of what we know about the function of endocannabinoids comes from studies that combine localization of endocannabinoid system components with physiological or behavioral approaches. ...
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), the enzymes that synthesize and degrade …
Marijuana, the Endocannabinoid System and the Female Reproductive System.
Brents LK. Yale J Biol Med 2016 - Review. PMID 27354844 Free PMC article.
Carefully controlled regulation of the Endocannabinoid System (ECS) is required for successful reproduction, and the exogenous cannabinoids in marijuana may disrupt the delicate balance of the ECS in the female reproductive system....
Carefully controlled regulation of the Endocannabinoid System (ECS) is required for successful reproduction, and the exogenous cannab …
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