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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 2
1990 18
1991 69
1992 53
1993 46
1994 59
1995 74
1996 403
1997 659
1998 776
1999 695
2000 825
2001 713
2002 650
2003 572
2004 680
2005 614
2006 621
2007 583
2008 583
2009 516
2010 550
2011 485
2012 508
2013 491
2014 484
2015 400
2016 363
2017 315
2018 260
2019 114
2020 1
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12,190 results
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Page 1
TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.
Padilla J, et al. Am J Physiol Heart Circ Physiol 2018. PMID 28971844 Free PMC article.
Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial dysfunction in diabetes. Although the detrimental vascular effects of increased ET-1 are well known, the molecular mechanisms regulating endothelial synthesis of ET-1 in the setting of diabetes remain largely unidentified. ...NEW & NOTEWORTHY This study provides the first evidence that the adapter molecule TRAF3 interacting protein 2 mediates high glucose-induced production of endothelin-1 by endothelial cells as well as endothelin-1-mediated endothelial cell inflammation. ...
Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial dysfunction in diabetes. Although the detri …
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes.
Chang W, et al. PLoS One 2018. PMID 29351334 Free PMC article.
Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endothelin receptor B, comparing proliferative diabetic retinopathy and idiopathic epiretinal membranes. ...Flatmount diabetic membranes showed co-localization of endothelin-1 with S100A4 and CD31. Immunohistochemistry and quantitative analysis of cross-sectional membranes showed significantly higher endothelin-1 labeling in proliferative diabetic retinopathy membranes compared to idiopathic membranes (p<0.05). ...
Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endot
Neprilysin inhibition and endothelin-1 elevation: Focus on the kidney.
Roksnoer LCW, et al. Eur J Pharmacol 2018. PMID 29432709
However, the neprilysin inhibitor thiorphan was recently found to increase endothelin-1 when administered to TGR(mREN2)27 (Ren2) rats on top of RAS blockade. ...Both urinary endothelin-1 and cGMP were significantly higher in the high-dose sacubitril group compared with the low-dose sacubitril group. ...
However, the neprilysin inhibitor thiorphan was recently found to increase endothelin-1 when administered to TGR(mREN2)27 (Ren …
Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model.
Nodai T, et al. J Dent Res 2018. PMID 29518348
Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. In the present study, we investigated the involvement of endothelin-1 signaling with oral ulcer-induced pain using our proprietary assay system in conscious rats. Endothelin-1 was significantly upregulated in oral ulcers experimentally induced by topical acetic acid treatment, while endothelin-1 production was suppressed by antibacterial pretreatment. ...
Endothelin-1 is upregulated in oral mucosal inflammation, although it has not been shown to induce pain in oral ulcers. In the
Endothelin-1 may play an important role in the Fontan circulation.
Aoki M, et al. Interact Cardiovasc Thorac Surg 2018. PMID 29177420
For 10 of these patients, quantitative real-time polymerase chain reaction analyses of ET-1, endothelin receptors Type A and Type B, endothelin-converting enzyme-1 and endothelial nitric oxide synthase were performed. ...Our data suggest that ET-1 may play an important role in maintaining the Fontan circulation....
For 10 of these patients, quantitative real-time polymerase chain reaction analyses of ET-1, endothelin receptors Type A and T …
Endothelin-1-induced expression of α-smooth muscle actin in human myometrial fibroblasts.
Duan Z, et al. J Obstet Gynaecol Res 2018. PMID 29271089
AIM: We aimed to investigate the potential role of endothelin-1 (ET-1) in the regulation of the expression of α-smooth muscle actin (α-SMA) in human myometrial fibroblasts. ...Then, 1 × 10(7) cells were treated with ET-1 at a concentration of 0.1, 1.0, 10.0, or 100.0 nM for 24 h. To investigate the time course effects of ET-1 on the growth of fibroblasts, 1 × 10(7) cells were treated with 10.0 nM ET-1 for 6, 12, 24, and 48 h. ...
AIM: We aimed to investigate the potential role of endothelin-1 (ET-1) in the regulation of the expression of α-smooth …
Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies.
Barta T, et al. Naunyn Schmiedebergs Arch Pharmacol 2018. PMID 29354880 Free PMC article.
Endothelin-1 (ET-1), a potent vasoconstrictor normally active in maintaining vascular tone, may mediate significant pathogenic effects, contributing to several serious diseases when aberrantly expressed or regulated. The present study evaluates the capacity of ET-1 to affect endothelin-1-associated hypertrophic activity and decreased expression of heme oxygenase-1 by H9c2 rat cardiomyoblasts in vitro, corresponding to in vivo processes underlying cardiovascular diseases (CVDs). ...
Endothelin-1 (ET-1), a potent vasoconstrictor normally active in maintaining vascular tone, may mediate significant pat
A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.
Gupta RM, et al. Cell 2017. PMID 28753427 Free PMC article.
CRISPR-edited stem cell-derived endothelial cells demonstrate rs9349379 regulates expression of endothelin 1 (EDN1), a gene located 600 kb upstream of PHACTR1. ...
CRISPR-edited stem cell-derived endothelial cells demonstrate rs9349379 regulates expression of endothelin 1 (EDN1), a gene lo …
Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease
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Raina R, et al. Clin Nephrol 2019 - Review. PMID 30990410
AIMS: Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression. ...All animal and human studies describing the effects of endothelin and endothelin-1 antagonists in ADPKD subjects were included in the review. ...
AIMS: Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD …
Cyclosporine A induces endothelin-converting enzyme-1: Studies in vivo and in vitro.
Heyman SN, et al. Acta Physiol (Oxf) 2018. PMID 29330945
AIM: Cyclosporine A (CsA) induces renal vasoconstriction and hypoxia and enhances the expression of endothelin-1 (ET-1) pro-hormone (pre-pro-ET-1), plausibly leading to a feed-forward loop of renal vasoconstriction, hypoxia and enhanced synthesis of the potent vasoconstrictor ET-1. Endothelin-converting enzyme (ECE)-1 cleaves big endothelin to generate endothelin (ET)-1 and is upregulated by hypoxia via hypoxia-inducible factor (HIF). ...
AIM: Cyclosporine A (CsA) induces renal vasoconstriction and hypoxia and enhances the expression of endothelin-1 (ET-1) …
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