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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1968 1
1983 1
1986 1
1987 84
1988 229
1989 345
1990 357
1991 388
1992 515
1993 532
1994 558
1995 649
1996 604
1997 683
1998 669
1999 666
2000 735
2001 797
2002 908
2003 845
2004 570
2005 487
2006 484
2007 436
2008 459
2009 451
2010 462
2011 485
2012 468
2013 475
2014 446
2015 432
2016 377
2017 345
2018 296
2019 124
2020 1
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15,408 results
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Page 1
Emerging Roles of Vascular Endothelium in Metabolic Homeostasis.
Pi X, et al. Circ Res 2018 - Review. PMID 30355249 Free PMC article.
The close anatomic relationship between vascular endothelium and highly vascularized metabolic organs/tissues suggests that the crosstalk between ECs and these organs is vital for both vascular and metabolic homeostasis. ...Emerging data suggest that the vascular endothelium plays an unexpected role in the regulation of metabolic homeostasis and that endothelial dysregulation directly contributes to the development of metabolic disorders. ...
The close anatomic relationship between vascular endothelium and highly vascularized metabolic organs/tissues suggests that th …
The endothelial glycocalyx: a review of the vascular barrier.
Alphonsus CS and Rodseth RN. Anaesthesia 2014 - Review. PMID 24773303 Free article.
The endothelial glycocalyx is an important part of the vascular barrier. The glycocalyx is intimately linked to the homoeostatic functions of the endothelium. Damage to the glycocalyx precedes vascular pathology. In the first part of this paper, we have reviewed the structure, physiology and pathology of the endothelial glycocalyx, based on a literature search of the past five years. ...
The endothelial glycocalyx is an important part of the vascular barrier. The glycocalyx is intimately linked to the homoeostatic func …
Targeting vascular (endothelial) dysfunction.
Daiber A, et al. Br J Pharmacol 2017 - Review. PMID 27187006 Free PMC article.
The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, circulation of blood cells, inflammation and platelet activity. ...Since vascular oxidative stress and inflammation are major determinants of endothelial function, we have also addressed current antioxidant and anti-inflammatory therapies. ...
The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, …
Nanomechanics of vascular endothelium.
Fels J, et al. Cell Tissue Res 2014 - Review. PMID 24643677 Free PMC article.
There is accumulating evidence that endothelial nanomechanics of these individual compartments control vascular physiology. Depending on protein composition, filament formation and interaction with cross-linker proteins, these four compartments determine endothelial stiffness. ...This review will focus on endothelial nanomechanics and its impact on vascular function....
There is accumulating evidence that endothelial nanomechanics of these individual compartments control vascular physiology. Depending …
Posttranscriptional adaptations of the vascular endothelium to hypoxia.
Ho JJ and Marsden PA. Curr Opin Hematol 2015 - Review. PMID 25767954
RECENT FINDINGS: Recent studies have revealed two emerging themes that are critical to endothelial/vascular biology and function. ...SUMMARY: Taken together, these findings bear significant diagnostic and therapeutic implications for vascular disease....
RECENT FINDINGS: Recent studies have revealed two emerging themes that are critical to endothelial/vascular biology and function. ... …
Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism.
Draoui N, et al. Open Biol 2017 - Review. PMID 29263247 Free PMC article.
Endothelial cell (EC) metabolism has lately emerged as a novel and promising therapeutic target to block vascular dysregulation associated with diseases like cancer and blinding eye disease. Glycolysis, fatty acid oxidation (FAO) and, more recently, glutamine/asparagine metabolism emerged as key regulators of EC metabolism, able to impact angiogenesis in health and disease. ...
Endothelial cell (EC) metabolism has lately emerged as a novel and promising therapeutic target to block vascular dysregulatio …
Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era.
Yan MS and Marsden PA. Arterioscler Thromb Vasc Biol 2015 - Review. PMID 26404488 Free PMC article.
A growing body of evidence suggests that epigenetic pathways play a key role in vascular biology and might be involved in defining and transducing cardiovascular disease inheritability. In this review, we argue the importance of epigenetics in vascular biology, especially from the perspective of endothelial cell phenotype. ...
A growing body of evidence suggests that epigenetic pathways play a key role in vascular biology and might be involved in defining an …
Vascular endothelium in cancer.
Nikitenko LL. Cell Tissue Res 2009 - Review. PMID 19015885
The vascular endothelium plays an essential role during organogenesis and in tissue homeostasis. Growing evidence also supports its essential and complex role in tumour biology and cancer progression. In particular, excessive proliferation and transformation or dysfunction of endothelial cells leads to pathological (lymph)angiogenesis or vascular malfunctions, which are hallmarks of neoplastic and malignant disorders. ...
The vascular endothelium plays an essential role during organogenesis and in tissue homeostasis. Growing evidence also support …
Epigenetic determinants of cardiovascular gene expression: vascular endothelium.
Man HS, et al. Epigenomics 2016 - Review. PMID 27381277
In vascular endothelial cells, evidence suggests that epigenetic mechanisms play a major role in the expression of endothelial cell-specific genes such as the endothelial nitric oxide synthase (NOS3/eNOS). ...
In vascular endothelial cells, evidence suggests that epigenetic mechanisms play a major role in the expression of endothelial cell-s …
Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium.
Wilson C, et al. J Physiol 2015. PMID 26507455 Free PMC article.
KEY POINTS: Increased pressure suppresses endothelial control of vascular tone but it remains uncertain (1) how pressure is sensed by the endothelium and (2) how the vascular response is inhibited. ...ABSTRACT: The endothelium is an interconnected network upon which haemodynamic mechanical forces act to control vascular tone and remodelling in disease. ...
KEY POINTS: Increased pressure suppresses endothelial control of vascular tone but it remains uncertain (1) how pressure is sensed by …
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