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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1987 19
1988 31
1989 51
1990 53
1991 87
1992 90
1993 110
1994 123
1995 110
1996 152
1997 177
1998 202
1999 230
2000 247
2001 298
2002 274
2003 335
2004 293
2005 371
2006 412
2007 413
2008 419
2009 385
2010 373
2011 410
2012 378
2013 420
2014 420
2015 365
2016 308
2017 289
2018 259
2019 94
2020 3
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7,400 results
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Page 1
Vascular endothelium dysfunction: a conservative target in metabolic disorders.
Jamwal S and Sharma S. Inflamm Res 2018 - Review. PMID 29372262
AIM: Vascular endothelium plays a role in capillary transport of nutrients and drugs and regulates angiogenesis, homeostasis, as well as vascular tone and permeability as a major regulator of local vascular homeostasis. ...The increased cholesterol and triglyceride level and decreased protective HDL level, decreases the activity and expression of eNOS and disrupts the integrity of vascular endothelium, due to oxidative stress. ...
AIM: Vascular endothelium plays a role in capillary transport of nutrients and drugs and regulates angiogenesis, homeostasis, …
Endothelial Functions
Godo S and Shimokawa H. Arterioscler Thromb Vasc Biol 2017 - Review. PMID 28835487
The endothelium plays important roles in modulating vascular tone by synthesizing and releasing a variety of endothelium-derived relaxing factors, including vasodilator prostaglandins, NO, and endothelium-dependent hyperpolarization factors, as well as endothelium-derived contracting factors. ...We herein will summarize the current knowledge on endothelial functions from bench to bedside with particular focus on recent publications in Arteriosclerosis, Thrombosis, and Vascular Biology....
The endothelium plays important roles in modulating vascular tone by synthesizing and releasing a variety of endothelium
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
Ungvari Z, et al. Nat Rev Cardiol 2018 - Review. PMID 29795441 Free PMC article.
A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of endothelium-dependent dilator responses (endothelial dysfunction) associated with impairment of angiogenic processes and the subsequent pathological remodelling of the microcirculation contribute to compromised tissue perfusion and exacerbate functional decline in older individuals. ...An improved understanding of endothelial biology in older patients is crucial for all cardiologists because maintenance of a competently functioning endothelium is critical for adequate tissue perfusion and long-term cardiac health....
A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of …
Role of free fatty acids in endothelial dysfunction
Ghosh A, et al. J Biomed Sci 2017 - Review. PMID 28750629 Free PMC article.
Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. ...
Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key pl …
Role of endothelial dysfunction in atherosclerosis
Davignon J and Ganz P. Circulation 2004 - Review. PMID 15198963
As the major regulator of vascular homeostasis, the endothelium exerts a number of vasoprotective effects, such as vasodilation, suppression of smooth muscle cell growth, and inhibition of inflammatory responses. ...Nitric oxide opposes the effects of endothelium-derived vasoconstrictors and inhibits oxidation of low-density lipoprotein. A defect in the production or activity of nitric oxide leads to endothelial dysfunction, signaled by impaired endothelium-dependent vasodilation. ...
As the major regulator of vascular homeostasis, the endothelium exerts a number of vasoprotective effects, such as vasodilatio …
Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.
Gimbrone MA. Am J Cardiol 1995 - Review. PMID 7532351
Vascular endothelium, the single-cell-thick lining of the cardiovascular system, is an important functional component of the blood vessel wall, actively participating in normal vascular physiology as well as the pathogenesis of vascular diseases such as atherosclerosis. The localized modulation of vascular endothelium to a non-adaptive functional state can be termed "endothelial dysfunction." ...
Vascular endothelium, the single-cell-thick lining of the cardiovascular system, is an important functional component of the b
Cellular and molecular basis of pulmonary arterial hypertension
Morrell NW, et al. J Am Coll Cardiol 2009 - Review. PMID 19555855 Free PMC article.
The process of pulmonary vascular remodeling is accompanied by endothelial dysfunction, activation of fibroblasts and smooth muscle cells, crosstalk between cells within the vascular wall, and recruitment of circulating progenitor cells. ...The crosstalk between endothelium and vascular smooth muscle is explored in the context of mutations in the bone morphogenetic protein type II receptor, alterations in angiopoietin-1/TIE2 signaling, and the serotonin pathway. ...
The process of pulmonary vascular remodeling is accompanied by endothelial dysfunction, activation of fibroblasts and smooth muscle c …
Endothelial Function: A Short Guide for the Interventional Cardiologist
Gori T. Int J Mol Sci 2018 - Review. PMID 30513819 Free PMC article.
An impaired function of the coronary endothelium is an important determinant of all stages of atherosclerosis, from initiation, to mediation of functional phenomena-such as spasm and plaque erosion, to atherothrombotic complications. ...In this review, we describe the role of the endothelium in the continuum of coronary atherosclerosis, from the perspective of the interventional cardiologist. ...
An impaired function of the coronary endothelium is an important determinant of all stages of atherosclerosis, from initiation, to me …
Pathophysiology of ischaemia-reperfusion injury
Carden DL and Granger DN. J Pathol 2000 - Review. PMID 10685060
Reperfusion of ischaemic tissues is often associated with microvascular dysfunction that is manifested as impaired endothelium-dependent dilation in arterioles, enhanced fluid filtration and leukocyte plugging in capillaries, and the trafficking of leukocytes and plasma protein extravasation in postcapillary venules. ...
Reperfusion of ischaemic tissues is often associated with microvascular dysfunction that is manifested as impaired endothelium-depend …
7,400 results
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