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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1960 2
1961 8
1962 2
1965 1
1966 13
1967 23
1968 21
1969 2
1972 1
1973 2
1974 10
1975 5
1976 2
1977 4
1978 2
1979 2
1981 1
1983 2
1984 2
1986 7
1987 6
1988 8
1989 166
1990 522
1991 549
1992 596
1993 628
1994 624
1995 724
1996 626
1997 751
1998 811
1999 714
2000 907
2001 1086
2002 1156
2003 1403
2004 1501
2005 1678
2006 1778
2007 2021
2008 2030
2009 1974
2010 2098
2011 2049
2012 1998
2013 2010
2014 1950
2015 1936
2016 1924
2017 1914
2018 1831
2019 794
2020 20
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36,770 results
Results by year
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Page 1
Glucose Metabolism in Cancer.
Bose S and Le A. Adv Exp Med Biol 2018 - Review. PMID 29946772
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1]. ...The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics which would later open the doors to new cancer therapies....
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his …
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone A, et al. Biol Rev Camb Philos Soc 2015 - Review. PMID 25243985 Free PMC article.
These functions require dynamic regulation of the PPP pathway that is achieved through hierarchical interactions between transcriptome, proteome and metabolome. ...These biochemical principles are discussed in the context of PPP deficiencies causing metabolic disease and the role of this pathway in biotechnology, bacterial and parasite infections, neurons, stem cell potency and cancer metabolism....
These functions require dynamic regulation of the PPP pathway that is achieved through hierarchical interactions between transcriptome, prot …
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.
Lunt SY and Vander Heiden MG. Annu Rev Cell Dev Biol 2011 - Review. PMID 21985671
Here, we review how glycolysis contributes to the metabolic processes of dividing cells. We provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass. We argue that the major function of aerobic glycolysis is to maintain high levels of glycolytic intermediates to support anabolic reactions in cells, thus providing an explanation for why increased glucose metabolism is selected for in proliferating cells throughout nature....
Here, we review how glycolysis contributes to the metabolic processes of dividing cells. We provide a detailed accounting of the bios …
Energy and metabolism.
Suarez RK. Compr Physiol 2012 - Review. PMID 23720257
Although firmly grounded in metabolic biochemistry, the study of energy metabolism has gone well beyond this discipline and become integrative and comparative as well as ecological and evolutionary in scope. ...Therefore, studies of energy metabolism have become, increasingly, experiments in systems biology. A significant challenge continues to be the integration of phenomena over multiple levels of organization. ...
Although firmly grounded in metabolic biochemistry, the study of energy metabolism has gone well beyond this discipline …
Body size, energy metabolism and lifespan.
Speakman JR. J Exp Biol 2005 - Review. PMID 15855403 Free article.
Bigger animals also expend more energy, and the scaling exponent for the relationship of resting metabolic rate (RMR) to body mass lies somewhere between 0.66 and 0.8. ...This fact led to the notion that ageing and lifespan are processes regulated by energy metabolism rates and that elevating metabolism will be associated with premature mortality--the rate of living theory. ...
Bigger animals also expend more energy, and the scaling exponent for the relationship of resting metabolic rate (RMR) to body …
Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1.
Sponton CH and Kajimura S. Endocrinology 2018 - Review. PMID 29757365 Free PMC article.
This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulation of energy homeostasis that are independent of the canonical thermogenic pathway via uncoupling protein 1....
This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulatio …
Basal metabolic rate studies in humans: measurement and development of new equations.
Henry CJ. Public Health Nutr 2005 - Review. PMID 16277825
OBJECTIVE: To facilitate the Food and Agriculture Organization/World Health Organization/United Nations University Joint (FAO/WHO/UNU) Expert Consultation on Energy and Protein Requirements which met in Rome in 1981, Schofield et al. reviewed the literature and produced predictive equations for both sexes for the following ages: 0-3, 3-10, 10-18, 18-30, 30-60 and >60 years. These formed the basis for the equations used in 1985 FAO/WHO/UNU document, Energy and Protein Requirements. While Schofield's analysis has served a significant role in re-establishing the importance of using basal metabolic rate (BMR) to predict human energy requirements, recent workers have subsequently queried the universal validity and application of these equations. ...
OBJECTIVE: To facilitate the Food and Agriculture Organization/World Health Organization/United Nations University Joint (FAO/WHO/UNU) Exper …
Physical activity and resting metabolic rate.
Speakman JR and Selman C. Proc Nutr Soc 2003 - Review. PMID 14692598
The direct effects of physical activity interventions on energy expenditure are relatively small when placed in the context of total daily energy demands. ...Resting metabolic rate (RMR) is the largest component of the daily energy budget in most human societies and, therefore, any increases in RMR in response to exercise interventions are potentially of great importance. ...
The direct effects of physical activity interventions on energy expenditure are relatively small when placed in the context of total …
Energy metabolism and drug efflux in Mycobacterium tuberculosis.
Black PA, et al. Antimicrob Agents Chemother 2014 - Review. PMID 24614376 Free PMC article.
This suggests that energy metabolism and ATP production through the PMF, which is established by the electron transport chain (ETC), are critical in determining the drug susceptibility of M. tuberculosis. ...
This suggests that energy metabolism and ATP production through the PMF, which is established by the electron transport chain …
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