Enhancement of learning and memory by elevating brain magnesium.
Neuron. 2010.
PMID: 20152124
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Enhancement of learning and memory by elevating brain magnesium.
Neuron. 2010 Jan 28;65(2):165-77. doi: 10.1016/j.neuron.2009.12.026.
Neuron. 2010.
PMID: 20152124
Free article.
Learning and memory are fundamental brain functions affected by dietary and environmental factors. ...Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiatio …
Learning and memory are fundamental brain functions affected by dietary and environmental factors. ...Our findin …
Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.
Neuropharmacology. 2016 Sep;108:426-39. doi: 10.1016/j.neuropharm.2016.05.006. Epub 2016 May 10.
Neuropharmacology. 2016.
PMID: 27178134
Free article.
Oral administration of the combination of L-threonate (threonate) and magnesium (Mg(2+)) in the form of L-Threonic acid Magnesium salt (L-TAMS) can enhance learning and memory in young rats and prevent memory decline in aging rats and in …
Oral administration of the combination of L-threonate (threonate) and magnesium (Mg(2+)) in the form of L-Threonic acid Magnesium …
Brain free magnesium homeostasis as a target for reducing cognitive aging.
In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.
In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.
PMID: 29920011
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According to these postulates, long-term increase in Mg(2+) levels facilitates the conversion of synapses to a plastic state while learning and memory capacities are enhanced in adult animals fed with a diet enriched in Mg(2+)-L-threonate, a treatment …
According to these postulates, long-term increase in Mg(2+) levels facilitates the conversion of synapses to a plastic state while learni …
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
Neurol Res. 2024 Aug;46(8):752-762. doi: 10.1080/01616412.2024.2352234. Epub 2024 May 8.
Neurol Res. 2024.
PMID: 38719201
To better understand the anxiety-modulating effects of Mg sulfate, behavioral test batteries in the assessment of anxiety and learning and memory functions were performed simultaneously over a time period. ...Mg treatment might counteract increased oxidative …
To better understand the anxiety-modulating effects of Mg sulfate, behavioral test batteries in the assessment of anxiety and learning …
Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.
Expert Opin Ther Targets. 2014 Oct;18(10):1121-30. doi: 10.1517/14728222.2014.941286. Epub 2014 Aug 24.
Expert Opin Ther Targets. 2014.
PMID: 25152202
Review.
INTRODUCTION: Age-related memory loss is believed to be a result of reduced synaptic plasticity, including changes in the NR2 subunit composition of the NMDA receptor. It is known that endogenous NR2B subunits decrease as the brain ages, whereas transgenic upregulation of …
INTRODUCTION: Age-related memory loss is believed to be a result of reduced synaptic plasticity, including changes in the NR2 subunit compos …
Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala.
J Neurosci. 2011 Oct 19;31(42):14871-81. doi: 10.1523/JNEUROSCI.3782-11.2011.
J Neurosci. 2011.
PMID: 22016520
Free PMC article.
We found that elevation of brain magnesium, by a novel magnesium compound [magnesium-l-threonate (MgT)], enhances synaptic plasticity in the hippocampus and learning and memory in rats. ...The current study suggests t …
We found that elevation of brain magnesium, by a novel magnesium compound [magnesium-l-threonate (MgT)], …
Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.
Mol Neurobiol. 2020 Jun;57(6):2539-2550. doi: 10.1007/s12035-020-01871-z. Epub 2020 Mar 25.
Mol Neurobiol. 2020.
PMID: 32215817
Free PMC article.
Extracellular magnesium ion ([Mg(2+)]) is a well-known voltage-dependent blocker of NMDA receptors, which plays a critical role in the regulation of neuronal plasticity, learning, and memory. ...In our current study, we found that extracellular [Mg(2+) …
Extracellular magnesium ion ([Mg(2+)]) is a well-known voltage-dependent blocker of NMDA receptors, which plays a critical role in th …
Modulation of olfactory bulb network activity by serotonin: synchronous inhibition of mitral cells mediated by spatially localized GABAergic microcircuits.
Learn Mem. 2014 Jul 16;21(8):406-16. doi: 10.1101/lm.035659.114. Print 2014 Aug.
Learn Mem. 2014.
PMID: 25031366
Free PMC article.
That serotonin-triggered coincident inhibition in the absence of elevated GC somatic firing rates suggested that synchronized MC inhibition arose from glutamate receptor-mediated depolarization of GC dendrites or other (non-GC) interneurons outside the glomerular layer. Te …
That serotonin-triggered coincident inhibition in the absence of elevated GC somatic firing rates suggested that synchronized MC inhi …
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