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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 1
1966 1
1967 2
1968 1
1969 16
1970 47
1971 41
1972 157
1973 194
1974 467
1975 732
1976 704
1977 413
1978 406
1979 371
1980 402
1981 379
1982 339
1983 406
1984 421
1985 586
1986 505
1987 503
1988 488
1989 587
1990 585
1991 523
1992 544
1993 498
1994 526
1995 510
1996 491
1997 637
1998 919
1999 1059
2000 1075
2001 1195
2002 1174
2003 1188
2004 1271
2005 1379
2006 1688
2007 1913
2008 1758
2009 1627
2010 1645
2011 1772
2012 1709
2013 1645
2014 1238
2015 1117
2016 1004
2017 849
2018 592
2019 277
2020 2
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37,549 results
Results by year
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Page 1
AMPK activators: mechanisms of action and physiological activities
Kim J, et al. Exp Mol Med 2016 - Review. PMID 27034026 Free PMC article.
Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. ...
Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therape …
Enzymes and nanoparticles: Modulation of enzymatic activity via nanoparticles
Arsalan A and Younus H. Int J Biol Macromol 2018 - Review. PMID 30006013
They increase the rate of reaction by lowering the activation energy required to convert the substrates into the products. The catalysis by an enzyme is influenced by the nature of medium, substrate, enzyme concentration, temperature, pH, and the presence of activators and inhibitors. ...Primary objective of writing this review is to give an overview of the various aspects of enzymology, enzyme catalysis, enzyme immobilization and modulation of enzyme activity with special emphasis on modulation through different types of nanoparticles including their synthesis, characterization and applications....
They increase the rate of reaction by lowering the activation energy required to convert the substrates into the products. The cataly …
Turning-ON Proteasomes
Krahn JH, et al. Cell Chem Biol 2017. PMID 28644955 Free article.
Structural insights into simocyclinone as an antibiotic, effector ligand and substrate
Buttner MJ, et al. FEMS Microbiol Rev 2018 - Review. PMID 29126195 Free PMC article.
Simocyclinones are antibiotics produced by Streptomyces and Kitasatospora species that inhibit the validated drug target DNA gyrase in a unique way, and they are thus of therapeutic interest. ...The crystal structures of simocyclinones bound to their target (gyrase), the transcriptional repressor SimR and the biosynthetic enzyme SimC7 reveal fascinating insight into how molecular recognition is achieved with these three unrelated proteins....
Simocyclinones are antibiotics produced by Streptomyces and Kitasatospora species that inhibit the validated drug target DNA gyrase i …
Stimulation of Laccase Biocatalysis in Ionic Liquids: A Review on Recent Progress
Liu H, et al. Curr Protein Pept Sci 2018 - Review. PMID 27875965
In addition, enzyme source, mediator, pH as well as water content are very important factors which influence laccase activity and stability. ...Strategies based on molecular evolution, enzyme immobilization and/or ILs modification greatly increase the tolerance of laccases against specific ILs. ...
In addition, enzyme source, mediator, pH as well as water content are very important factors which influence laccase activity and sta …
Small molecules as activators in medicinal chemistry (2000-2016)
Hameed A, et al. Expert Opin Ther Pat 2017 - Review. PMID 28673105
This has been the impetus behind the development of a plethora of drugs as enzyme inhibitors. However only a few enzyme activators as drugs have made it to the market. Disorders characterized by supressed enzyme activity can be treated by enhancing the activity of a specific enzyme....
This has been the impetus behind the development of a plethora of drugs as enzyme inhibitors. However only a few enzyme activa …
Protein Allostery in Rational Drug Design.
Kinoshita T. Adv Exp Med Biol 2019 - Review. PMID 31707699
Protein kinases are identified as drug targets because dysfunction of kinases leads to severe diseases such as cancers and autoimmune diseases. A large number of the crystal structures of the protein kinase inhibitor complex are available in Protein Data Bank and facilitated the drug discovery targeting protein kinases. ...
Protein kinases are identified as drug targets because dysfunction of kinases leads to severe diseases such as cancers and autoimmune …
Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy.
Szklarz GD and Halpert JR. Drug Metab Dispos 1998 - Review. PMID 9860924
These studies provide a basis for predicting drug interactions due to P450 inhibition and for rational inhibitor design. In addition, the location of P450 3A4 residues capable of influencing homotropic stimulation by substrates and heterotropic stimulation by flavonoids has been identified. Steroid hydroxylation by the wild-type enzyme exhibits sigmoidal kinetics, indicative of positive cooperativity. Based on the 3A4 model and single-site mutants, a double mutant in SRS-2 has been constructed that exhibits normal Michaelis-Menten kinetics. ...
These studies provide a basis for predicting drug interactions due to P450 inhibition and for rational inhibitor design. In addition, …
37,549 results
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