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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 2
1961 4
1962 1
1963 1
1964 1
1965 7
1966 18
1967 75
1968 89
1969 163
1970 160
1971 210
1972 223
1973 254
1974 245
1975 287
1976 262
1977 323
1978 252
1979 335
1980 304
1981 367
1982 419
1983 432
1984 541
1985 541
1986 521
1987 639
1988 586
1989 744
1990 1020
1991 797
1992 828
1993 871
1994 932
1995 922
1996 1129
1997 1335
1998 2128
1999 2375
2000 2817
2001 3616
2002 3857
2003 4400
2004 5294
2005 5971
2006 7024
2007 7785
2008 8345
2009 8494
2010 9106
2011 9879
2012 10428
2013 10695
2014 10263
2015 10294
2016 10157
2017 10193
2018 9576
2019 4139
2020 73
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154,541 results
Results by year
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Page 1
A single-cell survey of the small intestinal epithelium
Haber AL, et al. Nature 2017. PMID 29144463 Free PMC article.
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures. ...
Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune respons …
The role of transcription factor Nrf2 in skin cells metabolism.
Gęgotek A and Skrzydlewska E. Arch Dermatol Res 2015 - Review. PMID 25708189 Free PMC article.
Moreover, it has been observed that skin cells are also exposed to reactive oxygen species generated during cell metabolism particularly in relation to the synthesis of melanin or the metabolism in immune system cells. ...In the present study, the mechanisms of Nrf2 activation have been compared in the cells forming the various layers of the skin: keratinocytes, melanocytes, and fibroblasts. ...
Moreover, it has been observed that skin cells are also exposed to reactive oxygen species generated during cell metabolism pa …
A Single-Cell Transcriptome Atlas of the Mouse Glomerulus
Karaiskos N, et al. J Am Soc Nephrol 2018. PMID 29794128 Free PMC article.
We provide a comprehensive online atlas of gene expression in glomerular cells that can be queried and visualized using an interactive and freely available database. ...Subclustering of endothelial cells revealed a subset of endothelium that expressed marker genes related to endothelial proliferation. ...
We provide a comprehensive online atlas of gene expression in glomerular cells that can be queried and visualized using an interactiv …
Roles of membrane lipids in the organization of epithelial cells: Old and new problems.
Ikenouchi J. Tissue Barriers 2018 - Review. PMID 30156967 Free PMC article.
Historically, the concept of lipid raft arose from the analysis of lipid composition of the apical membrane, and it can be said that epithelial cells are an optimal experimental model for elucidating the functions of lipids. In this review, I discuss the role of lipids in the formation of epithelial polarity and in the formation of cell membrane structures of epithelial cells such as microvilli in the apical domain, cell-cell adhesion apparatus in the lateral domain and cell-matrix adhesion in the basal domain....
Historically, the concept of lipid raft arose from the analysis of lipid composition of the apical membrane, and it can be said that epit
PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.
Yang Q, et al. Nat Commun 2018. PMID 30405100 Free PMC article.
Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of protein kinase AMP-activated (PRKA)/AMP-activated protein kinases (AMPKs). ...In human endothelial cells, PRKAA1 is upregulated by disturbed flow, and silencing PRKAA1 reduces glycolysis and endothelial viability. ...
Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of protein kinase AMP-act …
[Blockade of programmed death-ligand 1 attenuates indirect acute lung injury in mice through targeting endothelial cells but not epithelial cells].
Sun B, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019. PMID 30707867 Chinese.
RESULTS: (1) Compared with sham group, PD-L1 expression on lung endothelial or epithelial cells were significantly elevated in i-ALI group [endothelial cells: (27.88±1.53)% vs. (19.64±1.03)%, epithelial cells: (58.70±8.21)% vs. (29.23±3.94)%, both P < 0.05]. (2) Mice received intravenous delivery of liposomal-encapsulated siRNA had significantly lower expression of PD-L1 on lung endothelial cells as compared with that of i-ALI group [(21.37±0.76)% vs. (27.88±1.53)%, P < 0.05]. ...CONCLUSIONS: PD-L1 silencing on endothelial cells but not epithelial cells protected mice against hemorrhagic shock-sepsis induced i-ALI....
RESULTS: (1) Compared with sham group, PD-L1 expression on lung endothelial or epithelial cells were significantly elevated in …
Update on the Mechanisms of Liver Regeneration
Preziosi ME and Monga SP. Semin Liver Dis 2017 - Review. PMID 28564722 Free PMC article.
Liver possesses many critical functions such as synthesis, detoxification, and metabolism. It continually receives nutrient-rich blood from gut, which incidentally is also toxin-rich. ...Although the exact mechanisms that initiate regeneration are unknown, alterations in hemodynamics and metabolism have been suspected as important effectors. ...
Liver possesses many critical functions such as synthesis, detoxification, and metabolism. It continually receives nutrient-rich bloo …
Expression of tricellulin in epithelial cells and non-epithelial cells.
Kojima T, et al. Histol Histopathol 2013 - Review. PMID 24101385
Tricellulin is the first molecular component of tricellular tight junctions at tricellular contacts where three epithelial cells meet, and it is required for the their formation and maintenance of the epithelial barrier. ...Tricellulin is also detected in endothelial cells, neurons, microglia and astrocytes. Here, we focused tricellulin expression in various types of epithelial cells, nasal epithelial cells, pancreatic duct epithelial cells cells and hepatocytes, and non-epithelial cells, dendritic cells and Schwann cells, compared to expression of the bicellular tight junction protein occludin and LSR, and discuss the regulation and the role of tricellulin in cellular specificity....
Tricellulin is the first molecular component of tricellular tight junctions at tricellular contacts where three epithelial cells
Functional and Genetic Analysis of Epiplakin in Epithelial Cells.
Szabo S, et al. Methods Enzymol 2016 - Review. PMID 26778563
Epiplakin is a large member (>700 kDa) of the plakin protein family and exclusively expressed in epithelial cell types. Compared to other plakin proteins epiplakin exhibits an unusual structure as it consists entirely of a variable number of consecutive plakin repeat domains (13 in humans, 16 in mice). ...However, ex vivo studies using epiplakin-deficient primary cells indicated protective functions of epiplakin in response to stress. ...
Epiplakin is a large member (>700 kDa) of the plakin protein family and exclusively expressed in epithelial cell types. Compared t …
Endocytosis of tight junction proteins and the regulation of degradation and recycling
Stamatovic SM, et al. Ann N Y Acad Sci 2017 - Review. PMID 28415156 Free PMC article.
Internalization of tight junction (TJ) proteins from the plasma membrane is a pivotal mechanism regulating TJ plasticity and function in both epithelial and endothelial barrier tissues. ...This review highlights recent advances in our knowledge of endocytosis and vesicular trafficking of TJ proteins in both epithelial and endothelial cells. ...
Internalization of tight junction (TJ) proteins from the plasma membrane is a pivotal mechanism regulating TJ plasticity and function in bot …
154,541 results
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