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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1121
1844 1251
1845 1279
1846 1404
1847 1368
1848 1204
1849 1209
1850 1126
1851 1228
1852 1312
1853 1559
1854 1306
1855 1588
1856 1588
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1139
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1810
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2181
1878 2455
1879 2399
1880 2646
1881 3149
1882 2743
1883 3128
1884 3050
1885 3338
1886 3291
1887 3965
1888 4002
1889 4196
1890 4025
1891 3607
1892 4065
1893 4369
1894 3801
1895 4129
1896 4413
1897 4688
1898 4632
1899 4169
1900 3786
1901 3887
1902 3968
1903 3910
1904 4060
1905 4067
1906 3872
1907 4324
1908 4459
1909 4687
1910 4799
1911 5007
1912 4906
1913 5106
1914 5135
1915 4641
1916 4543
1917 4281
1918 4568
1919 4618
1920 4960
1921 4628
1922 4123
1923 4432
1924 4850
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5546
1933 5610
1934 5507
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53735
1947 64959
1948 70710
1949 62804
1950 85750
1951 103742
1952 108055
1953 108914
1954 105914
1955 108542
1956 107005
1957 111515
1958 109456
1959 109958
1960 112134
1961 120098
1962 125630
1963 141519
1964 162086
1965 176638
1966 179747
1967 191511
1968 207849
1969 215051
1970 218966
1971 222914
1972 227524
1973 230665
1974 234544
1975 248279
1976 250543
1977 250334
1978 258735
1979 266129
1980 267692
1981 271949
1982 283549
1983 295217
1984 303151
1985 319404
1986 331872
1987 347976
1988 364472
1989 378525
1990 383746
1991 381768
1992 383345
1993 391391
1994 402938
1995 412164
1996 422361
1997 420098
1998 437897
1999 455167
2000 492161
2001 504690
2002 522446
2003 550254
2004 593788
2005 652424
2006 699377
2007 735493
2008 782739
2009 821884
2010 884375
2011 958382
2012 1024568
2013 1075676
2014 1127756
2015 1168264
2016 1199607
2017 1219692
2018 1262975
2019 1320206
2020 1505364
2021 1643675
2022 1638978
2023 1547595
2024 1137893
2025 588

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35,386,782 results

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Quoted phrases not found in phrase index: "Immunologic Factors Chemical Synthesis Pharmacology", "Macrophages Drug Effects Immunology", "Peptides Chemical Synthesis Pharmacology", "Surface Active Agents Chemical Synthesis Pharmacology"
Page 1
Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics.
Erak M, Bellmann-Sickert K, Els-Heindl S, Beck-Sickinger AG. Erak M, et al. Bioorg Med Chem. 2018 Jun 1;26(10):2759-2765. doi: 10.1016/j.bmc.2018.01.012. Epub 2018 Jan 31. Bioorg Med Chem. 2018. PMID: 29395804 Review.
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. ...In this mini-review, we present a toolbox of modifications in peptide chemistry for overcomi …
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides …
Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways.
Kerwin BA. Kerwin BA. J Pharm Sci. 2008 Aug;97(8):2924-35. doi: 10.1002/jps.21190. J Pharm Sci. 2008. PMID: 17973307 Review.
Polysorbates 20 and 80 (Tween 20 and Tween 80) are used in the formulation of biotherapeutic products for both preventing surface adsorption and as stabilizers against protein aggregation. ...Oxidation of the fatty acid moiety while well described in the literature has not …
Polysorbates 20 and 80 (Tween 20 and Tween 80) are used in the formulation of biotherapeutic products for both preventing surface ads …
Syntex adjuvant formulation.
Allison AC, Byars NE. Allison AC, et al. Res Immunol. 1992 Jun;143(5):519-25. doi: 10.1016/0923-2494(92)80063-q. Res Immunol. 1992. PMID: 1439132 Review. No abstract available.
Synthetic and Natural Lipase Inhibitors.
Bialecka-Florjanczyk E, Fabiszewska AU, Krzyczkowska J, Kurylowicz A. Bialecka-Florjanczyk E, et al. Mini Rev Med Chem. 2018;18(8):672-683. doi: 10.2174/1389557516666160630123356. Mini Rev Med Chem. 2018. PMID: 27484624 Review.
The aim of this review is to summarise the current knowledge concerning human, animal and microbial lipase inhibitors, which were grouped into two categories: synthetic lipase inhibitors (including phosphonates, boronic acids and fats analogues) and natural compounds (incl …
The aim of this review is to summarise the current knowledge concerning human, animal and microbial lipase inhibitors, which were gro …
Amphipathic, alpha-helical antimicrobial peptides.
Tossi A, Sandri L, Giangaspero A. Tossi A, et al. Biopolymers. 2000;55(1):4-30. doi: 10.1002/1097-0282(2000)55:1<4::AID-BIP30>3.0.CO;2-M. Biopolymers. 2000. PMID: 10931439 Review.
In this review, alpha-helical antimicrobial peptides are considered from the point of view of six interrelated structural and physicochemical parameters that modulate their activity and specificity: sequence, size, structuring, charge, amphipathicity, and hydrophobicity …
In this review, alpha-helical antimicrobial peptides are considered from the point of view of six interrelated structural and physico …
Molecular design of peptide amphiphiles for controlled self-assembly and drug release.
Liu Z, Tang X, Feng F, Xu J, Wu C, Dai G, Yue W, Zhong W, Xu K. Liu Z, et al. J Mater Chem B. 2021 Apr 21;9(15):3326-3334. doi: 10.1039/d1tb00173f. Epub 2021 Mar 26. J Mater Chem B. 2021. PMID: 33881438
Peptide amphiphile-based supramolecular hydrogels hold great promise in drug delivery applications. To cater for a specific drug dose in a demanding biomedical scenario, sophisticated design of peptide amphiphile (PA) molecules is required to tune thei …
Peptide amphiphile-based supramolecular hydrogels hold great promise in drug delivery applications. To cater for a specific …
Sequence-Defined DNA Amphiphiles for Drug Delivery: Synthesis and Self-Assembly.
Dore MD, Sleiman HF. Dore MD, et al. Methods Mol Biol. 2020;2063:87-100. doi: 10.1007/978-1-0716-0138-9_8. Methods Mol Biol. 2020. PMID: 31667765
DNA nanotechnology has been used to create DNA containing nanostructures with well-defined sizes and shapes-properties highly applicable to drug delivery. By appending sequence-defined hydrophobic segments to DNA, DNA amphiphiles are created whose structures and modes of s …
DNA nanotechnology has been used to create DNA containing nanostructures with well-defined sizes and shapes-properties highly applicable to …
Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.
Callmann CE, Thompson MP, Gianneschi NC. Callmann CE, et al. Acc Chem Res. 2020 Feb 18;53(2):400-413. doi: 10.1021/acs.accounts.9b00518. Epub 2020 Jan 22. Acc Chem Res. 2020. PMID: 31967781 Free PMC article.
Moreover, in addition to the sequence-controlled peptides (generated by solid phase synthesis), the polymer can carry its own sequence-dependent information, especially through living polymerization strategies allowing well-defined blocks and terminal labels …
Moreover, in addition to the sequence-controlled peptides (generated by solid phase synthesis), the polymer can carry i …
Living polypeptides.
Aliferis T, Iatrou H, Hadjichristidis N. Aliferis T, et al. Biomacromolecules. 2004 Sep-Oct;5(5):1653-6. doi: 10.1021/bm0497217. Biomacromolecules. 2004. PMID: 15360270
Block copolypeptides, which combine the self-assembly of block copolymers and the highly ordered 3D structures of proteins, are potential candidates for novel supramolecular structures and biotech applications, such as biosensors, tissue engineering, and selective drug del …
Block copolypeptides, which combine the self-assembly of block copolymers and the highly ordered 3D structures of proteins, are potential ca …
Immunomodulatory properties of surfactant preparations.
Bersani I, Kunzmann S, Speer CP. Bersani I, et al. Expert Rev Anti Infect Ther. 2013 Jan;11(1):99-110. doi: 10.1586/eri.12.156. Expert Rev Anti Infect Ther. 2013. PMID: 23428105 Review.
In this review, we describe the immunomodulatory features of surfactant preparations. Various surfactant preparations decrease the proinflammatory cytokine and chemokine release, the oxidative burst activity, and the nitric oxide production in lung inflammato …
In this review, we describe the immunomodulatory features of surfactant preparations. Various surfactant preparations decrease …
35,386,782 results
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