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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 2
1983 10
1984 6
1985 3
1986 9
1987 7
1988 9
1989 12
1990 8
1991 13
1992 11
1993 8
1994 9
1995 11
1996 11
1997 12
1998 12
1999 14
2000 9
2001 12
2002 9
2003 14
2004 17
2005 13
2006 7
2007 16
2008 22
2009 22
2010 28
2011 22
2012 31
2013 32
2014 29
2015 28
2016 33
2017 29
2018 30
2019 50
2020 37
2021 33
2022 13
2023 6
2024 6

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652 results

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Page 1
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.
Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. Zeng X, et al. Nat Cancer. 2022 Sep;3(9):1088-1104. doi: 10.1038/s43018-022-00429-3. Epub 2022 Sep 22. Nat Cancer. 2022. PMID: 36138131
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Chan EM, et al. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10. Nature. 2019. PMID: 30971823 Free PMC article.
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G, Cattaneo CM, van Vliet EJ, Crisafulli G, Rospo G, Consonni S, Vieira SF, Rodríguez IS, Cancelliere C, Banerjee R, Schipper LJ, Oddo D, Dijkstra KK, Cinatl J, Michaelis M, Yang F, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Arena S, Voest EE, Bardelli A, Garnett MJ; Cell Model Network UK Group. Picco G, et al. Cancer Discov. 2021 Aug;11(8):1923-1937. doi: 10.1158/2159-8290.CD-20-1508. Epub 2021 Apr 9. Cancer Discov. 2021. PMID: 33837064 Free article.
Are there Different Kinds of Aging?
Diaconeasa AG, Rachita M. Diaconeasa AG, et al. Curr Aging Sci. 2018;11(1):55-62. doi: 10.2174/1874609810666171116163047. Curr Aging Sci. 2018. PMID: 29149836 Review.
TREX1 plays multiple roles in human diseases.
Wang Q, Du J, Hua S, Zhao K. Wang Q, et al. Cell Immunol. 2022 May;375:104527. doi: 10.1016/j.cellimm.2022.104527. Epub 2022 Apr 21. Cell Immunol. 2022. PMID: 35468328 Review.
652 results