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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 22
1981 28
1982 37
1983 39
1984 43
1985 43
1986 46
1987 53
1988 67
1989 65
1990 49
1991 76
1992 56
1993 47
1994 40
1995 59
1996 43
1997 37
1998 51
1999 47
2000 51
2001 41
2002 42
2003 42
2004 48
2005 73
2006 31
2007 36
2008 43
2009 59
2010 80
2011 72
2012 56
2013 56
2014 66
2015 54
2016 45
2017 44
2018 45
2019 30
2020 5
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1,916 results
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Page 1
MicroRNAs in idiopathic pulmonary fibrosis, new research progress and their pathophysiological implication
Miao C, et al. Exp Lung Res 2018 - Review. PMID 29683754
Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the occurrence of IPF disease, which may be IPF diagnostic markers and prognostic indicators. Furthermore, studies have shown that miRNAs are involved in the pathological mechanisms of IPF, including the lung epithelial repair, epithelial-mesenchymal transition (EMT), fibroblast activation, myofibroblast differentiation, macrophage polarization, alveolar epithelial cells (AEC) senescence and collagen production. ...
Recent studies have shown that miRNAs differentially expressed in blood and lung tissue from IPF patients are closely related to the …
The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis.
Williamson JD, et al. Exp Lung Res 2015 - Review. PMID 25514507
Bleomycin, an anti-neoplastic agent that causes lung fibrosis in human patients has been used extensively in rodent models to mimic IPF. ...We discuss the current understanding of IPF and BPF disease development, from the contribution of alveolar epithelial cells and inflammation to the role of fibroblasts and cytokines, and draw conclusions about what we have learned from the intratracheal bleomycin model of lung fibrosis....
Bleomycin, an anti-neoplastic agent that causes lung fibrosis in human patients has been used extensively in rodent models to mimic I …
NOTCH signaling in lung diseases.
Jiang J, et al. Exp Lung Res 2017 - Review. PMID 28636457
Specifically, NOTCH plays an essential role in the development and homeostasis of the lung. Aberrations in NOTCH signaling or components of the signaling system have been linked to various pulmonary pathological conditions. We herein provide a brief overview of collective in vitro and in vivo studies of NOTCH signaling to illustrate its regulatory functions in lung diseases, including asthma, chronic obstructive pulmonary disease, pulmonary arterial hypertension, and lung cancer. ...
Specifically, NOTCH plays an essential role in the development and homeostasis of the lung. Aberrations in NOTCH signaling or compone …
Rux largely restores lungs in Iraq PM-exposed mice, Up-regulating regulatory T-cells (Tregs)
Lin D, et al. Exp Lung Res 2018. PMID 29737931 Free PMC article.
Lung histology, inspiratory capacity (FlexiVent), thymic/splenic regulatory T cell (Treg) number, and whole-lung genomics were analyzed. ...Drinking RuX after PM exposure attenuated the histologic lung injury response, improved lung inspiratory capacity, and increased Tregs. ...
Lung histology, inspiratory capacity (FlexiVent), thymic/splenic regulatory T cell (Treg) number, and whole-lung genomics were
Improved protocol for simultaneous analysis of leukocyte subsets and epithelial cells from murine and human lung.
Happle C, et al. Exp Lung Res 2018. PMID 29677457
PURPOSE: To study and isolate lung cells by flow cytometry, enzymatic digestion and generation of single cell suspensions is required. ...As such, they may help to comprehensively and sustainably characterize murine and human lung specimens and facilitate studies on the role of lung immune cells in different respiratory pathologies....
PURPOSE: To study and isolate lung cells by flow cytometry, enzymatic digestion and generation of single cell suspensions is required …
Corrigendum
[No authors listed] Exp Lung Res 2016. PMID 27380365
CB2R agonist prevents nicotine induced lung fibrosis.
Wawryk-Gawda E, et al. Exp Lung Res 2018. PMID 30675824
PURPOSE: We investigated the impact of CB2R agonist, JWH 133 and the antagonist, AM630 on lung tissue, applied directly before nicotine application. ...CONCLUSION: Nicotine induces interstitial lung fibrosis that is enhanced by the CB2R antagonist and diminished by the CB2R agonist. ...
PURPOSE: We investigated the impact of CB2R agonist, JWH 133 and the antagonist, AM630 on lung tissue, applied directly before nicoti …
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis.
Kugler MC, et al. Exp Lung Res 2019. PMID 30982371
Sonic Hedgehog (SHH) signaling, a developmental pathway promoting lung mesenchymal expansion and differentiation during embryogenesis, has been increasingly recognized as a profibrotic factor in mature lung, where it might contribute to the pathogenesis of lung fibrosis. ...Lung evaluation at the 21-day endpoint did not show differences in lung fibrosis formation (as judged by morphology and trichrome staining), Ashcroft score, lung collagen content, lung weight, BAL protein content or BAL cell differential count. ...
Sonic Hedgehog (SHH) signaling, a developmental pathway promoting lung mesenchymal expansion and differentiation during embryogenesis …
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