Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1948 1
1955 1
1958 1
1959 1
1961 4
1962 11
1963 25
1964 59
1965 58
1966 51
1967 32
1968 39
1969 35
1970 26
1971 32
1972 40
1973 33
1974 48
1975 42
1976 34
1977 29
1978 32
1979 42
1980 32
1981 64
1982 79
1983 75
1984 80
1985 133
1986 117
1987 178
1988 165
1989 199
1990 232
1991 241
1992 310
1993 259
1994 288
1995 282
1996 326
1997 362
1998 459
1999 472
2000 542
2001 550
2002 584
2003 629
2004 564
2005 618
2006 678
2007 680
2008 750
2009 689
2010 665
2011 733
2012 689
2013 634
2014 666
2015 611
2016 547
2017 465
2018 511
2019 208
2020 2
Text availability
Article attribute
Article type
Publication date

Search Results

15,984 results
Results by year
Filters applied: . Clear all
Page 1
[Ciliopathies]
Gerth-Kahlert C and Koller S. Klin Monbl Augenheilkd 2018 - Review. PMID 29534263 German.
Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors
Blanco-Suarez E, et al. Neuron 2018. PMID 30344043 Free PMC article.
Using biochemical fractionation of astrocyte-secreted proteins and mass spectrometry, we identified that astrocyte-secreted chordin-like 1 (Chrdl1) is necessary and sufficient to induce mature GluA2-containing synapses to form. This function of Chrdl1 is independent of its role as an antagonist of bone morphogenetic proteins (BMPs). Chrdl1 expression is restricted to cortical astrocytes in vivo, peaking at the time of the AMPAR switch. ...
Using biochemical fractionation of astrocyte-secreted proteins and mass spectrometry, we identified that astrocyte-secreted chordin-l …
Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes
Rheaume BA, et al. Nat Commun 2018. PMID 30018341 Free PMC article.
Retinal ganglion cells (RGCs) convey the major output of information collected from the eye to the brain. Thirty subtypes of RGCs have been identified to date. ...Zic1, a marker of the right eye-enriched subtype, is validated by immunostaining in situ. Runx1 and Fst, the markers of other subtypes, are validated in purified RGCs by fluorescent in situ hybridization (FISH) and immunostaining. ...
Retinal ganglion cells (RGCs) convey the major output of information collected from the eye to the brain. Thirty subtypes of RGCs hav …
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
Buskin A, et al. Nat Commun 2018. PMID 30315276 Free PMC article.
Mis-splicing of genes encoding pre-mRNA splicing proteins was limited to patient-specific retinal cells and Prpf31(+/-) mouse retinae and RPE. ...In situ gene editing of a pathogenic mutation rescued protein expression and key cellular phenotypes in RPE and photoreceptors, providing proof of concept for future therapeutic strategies....
Mis-splicing of genes encoding pre-mRNA splicing proteins was limited to patient-specific retinal cells and Prpf31(+/-) mouse retinae …
On the origin of proteins in human drusen: The meet, greet and stick hypothesis.
Bergen AA, et al. Prog Retin Eye Res 2019 - Review. PMID 30572124
These "drusenomics" studies showed that a considerable proportion of currently identified drusen proteins is uniquely originating from the blood. A smaller, but still large fraction of drusen proteins comes from both blood and/or RPE. Only a small proportion of drusen proteins is uniquely derived from the photoreceptors or choroid. ...
These "drusenomics" studies showed that a considerable proportion of currently identified drusen proteins is uniquely originating fro …
Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery
Cukras C, et al. Mol Ther 2018 - Clinical Trial. PMID 30196853 Free PMC article.
Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfunction, reduced visual acuity, and susceptibility to retinal detachment. ...Three participants were assigned to each of three dosage groups: 1e9 vector genomes (vg)/eye, 1e10 vg/eye, and 1e11 vg/eye. The investigational product was generally well tolerated in all but one individual. ...
Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfunction, …
Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin
Miller SJ, et al. Nat Neurosci 2019. PMID 30936556 Free PMC article.
These astroglia are enriched in mouse cortical layer V; express distinct molecular markers, including Norrin and leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6), with corresponding layer-specific neuronal ligands; are found in the human cortex; and modulate neuronal activity. ...
These astroglia are enriched in mouse cortical layer V; express distinct molecular markers, including Norrin and leucine-rich repeat-contain …
15,984 results
Jump to page
Feedback