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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 8
1995 44
1996 137
1997 282
1998 402
1999 494
2000 566
2001 582
2002 527
2003 510
2004 463
2005 459
2006 422
2007 402
2008 362
2009 339
2010 296
2011 308
2012 271
2013 290
2014 262
2015 237
2016 194
2017 177
2018 150
2019 57
2020 1
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7,657 results
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Page 1
The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.
Rieux-Laucat F, et al. J Clin Immunol 2018 - Review. PMID 29911256
The genetic etiology of the ALPS was described in 1995 by the discovery of the FAS gene mutations. The related apoptosis defect accounts for the accumulation of autoreactive lymphocytes as well as for specific clinical and biological features that distinguish the ALPS-FAS from other monogenic defects of this apoptosis pathway, such as FADD and CASPASE 8 deficiencies. The ALPS-FAS was the first description of a monogenic cause of autoimmunity, but its non-Mendelian expression remained elusive until the description of somatic and germline mutations in ALPS patients. ...
The genetic etiology of the ALPS was described in 1995 by the discovery of the FAS gene mutations. The related apoptosis defect accou …
Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.
Headen DM, et al. Nat Mater 2018. PMID 29867165 Free PMC article.
T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. ...
T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensiti …
Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death.
Glukhova XA, et al. Cell Death Dis 2018. PMID 29358576 Free PMC article.
Here, we demonstrate that Fas-ligand physically associates with caveolin-1, the main protein component of rafts. Experiments with cells overexpressing Fas-ligand revealed a FasL N-terminal pre-prolin-rich region, which is essential for the association with caveolin-1. ...These results demonstrate that the interaction of Fas-ligand and caveolin-1 represents a molecular basis for Fas-ligand translocation to rafts, and the subsequent induction of Fas-ligand-dependent cell death. ...
Here, we demonstrate that Fas-ligand physically associates with caveolin-1, the main protein component of rafts. Experi …
Relationship between Fas and Fas Ligand gene polymorphisms and pre-eclampsia.
Masoumi E, et al. J Obstet Gynaecol Res 2016. PMID 27277758
Polymorphisms in the Fas and Fas Ligand (FasL) promoter regions can influence Fas and FasL expression and accused to increase of Th1 subtype. ...CONCLUSION: The Fas-1377G > A polymorphism is associated with a higher risk of pre-eclampsia....
Polymorphisms in the Fas and Fas Ligand (FasL) promoter regions can influence Fas and FasL expression and accuse …
FAS and FAS ligand gene polymorphisms in Egyptian females with preeclampsia.
Nasr AS, et al. J Reprod Immunol 2014 - Clinical Trial. PMID 24951049
We aimed to evaluate the association of Fas polymorphism and the Fas ligand with preeclampsia, investigating whether the G 670 Fas gene variant and the Fas Ligand INV2nt 124 G variant had a differential distribution in patients with preeclampsia. ...Fas and Fas ligand gene polymorphisms were tested using polymerase chain reaction-restriction fragment length polymorphism. Regarding the Fas 670 A>G polymorphism, statistically significant differences were found between the two groups regarding the AA and GG/AG genotypes as well as the A, G allele frequency, while no statistically significant differences were found regarding AG or GG genotypes. ...
We aimed to evaluate the association of Fas polymorphism and the Fas ligand with preeclampsia, investigating whether th …
Fas ligand based immunotherapy: A potent and effective neoadjuvant with checkpoint inhibitor properties, or a systemically toxic promoter of tumor growth?
Modiano JF and Bellgrau D. Discov Med 2016 - Review. PMID 27011046 Free article.
Fas ligand (FasL, CD95L) is a 40-kDa type II transmembrane protein that binds to Fas (CD95) receptors and promotes programmed cell death. ...Somewhat paradoxically, elimination of Fas or FasL from tumors also leads to death induced by CD95 receptor/ligand elimination (DICE). ...
Fas ligand (FasL, CD95L) is a 40-kDa type II transmembrane protein that binds to Fas (CD95) receptors and promot
Nonapoptotic functions of Fas/CD95 in the immune response.
Guégan JP and Legembre P. FEBS J 2018 - Review. PMID 29032605 Free article.
CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. ...Transmembrane CD95L (m-CD95L) can be cleaved by metalloproteases, releasing a soluble ligand (s-CD95L). Soluble and membrane-bound CD95L show different stoichiometry (homotrimer versus multimer of homotrimers, respectively), which differentially affects CD95-mediated signaling through molecular mechanisms that remain to be elucidated. ...
CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is i …
The relationship between Fas and Fas ligand gene polymorphism and preeclampsia risk.
Wang T and Lian Y. Biosci Rep 2019. PMID 30718366 Free PMC article.
Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand (FasL) genes and the risk of preeclampsia. ...Seven citations containing nine studies were included for four SNPs (Fas -670 A/G, FasL 124A/G, FasL -844C/T, Fas -1377 G/A) in this meta-analysis. ...
Several studies investigated the association between various single-nucleotide polymorphisms (SNPs) in Fas and Fas ligand
Induction of apoptosis in breast cancer cells in vitro by Fas ligand reverse signaling.
Kolben T, et al. J Cancer Res Clin Oncol 2018. PMID 29185091
The ability of a Fas:Fc fusion protein to trigger apoptosis in these cells was investigated by cell death detection ELISA. After incubation with IFNγ for 4 h and 18 h, apoptosis was assessed in response to treatment with Fas:Fc. ...More importantly, in the presence of IFNγ the Fas:Fc fusion protein was able to transmit pro-apoptotic signals to T47D and MCF7 cells, significantly inducing apoptosis. ...
The ability of a Fas:Fc fusion protein to trigger apoptosis in these cells was investigated by cell death detection ELISA. Aft …
Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre-eclampsia.
Salimi S, et al. J Obstet Gynaecol Res 2014. PMID 24690069
FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand A-670G (rs1800682) and FAS Ligand C-844T (rs763110) gene polymorphisms with PE in southeast Iran. ...
FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represen
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