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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 8
1995 44
1996 137
1997 282
1998 402
1999 494
2000 566
2001 582
2002 527
2003 510
2004 463
2005 459
2006 422
2007 402
2008 362
2009 339
2010 296
2011 308
2012 271
2013 290
2014 262
2015 237
2016 194
2017 177
2018 150
2019 59
2020 1
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7,659 results
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Page 1
The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.
Rieux-Laucat F, et al. J Clin Immunol 2018 - Review. PMID 29911256
The genetic etiology of the ALPS was described in 1995 by the discovery of the FAS gene mutations. The related apoptosis defect accounts for the accumulation of autoreactive lymphocytes as well as for specific clinical and biological features that distinguish the ALPS-FAS from other monogenic defects of this apoptosis pathway, such as FADD and CASPASE 8 deficiencies. The ALPS-FAS was the first description of a monogenic cause of autoimmunity, but its non-Mendelian expression remained elusive until the description of somatic and germline mutations in ALPS patients. ...
The genetic etiology of the ALPS was described in 1995 by the discovery of the FAS gene mutations. The related apoptosis defect accou …
Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death.
Glukhova XA, et al. Cell Death Dis 2018. PMID 29358576 Free PMC article.
The deletion of both caveolin-binding sites in Fas-ligand impairs its distribution between cellular membranes, and attenuates a Fas-ligand-induced cytotoxicity. These results demonstrate that the interaction of Fas-ligand and caveolin-1 represents a molecular basis for Fas-ligand translocation to rafts, and the subsequent induction of Fas-ligand-dependent cell death. ...
The deletion of both caveolin-binding sites in Fas-ligand impairs its distribution between cellular membranes, and attenuates …
Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.
Headen DM, et al. Nat Mater 2018. PMID 29867165 Free PMC article.
T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. ...
T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensiti …
Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
Benmebarek MR, et al. Int J Mol Sci 2019 - Review. PMID 30875739 Free PMC article.
These cells then mediate their anti-tumoral effects through the perforin and granzyme axis, the Fas and Fas ligand axis, as well as the release of cytokines to sensitize the tumor stroma. ...
These cells then mediate their anti-tumoral effects through the perforin and granzyme axis, the Fas and Fas ligand axis …
Fas and Fas ligand gene polymorphisms in Turkish patients with Familial Mediterranean Fever.
Ozel EG, et al. Gene 2017. PMID 28442396
Fas and Fas ligand molecules play a central role in the apoptosis signaling of various cell types including neutrophils. Neutrophils are the major cell population involved in acute inflammation in patients with FMF and the role of Fas and Fas ligand molecules in this cells of FMF patients may be crucial. Therefore, in the present study, we aimed to investigate whether the Fas cell surface receptor gene (FAS); NM_000043.5: c.-671A>G (rs1800682, MvaI) and Fas ligand gene (FASLG), NM_000639.2: c.-844C>T (rs763110, BsrD1) functional polymorphisms in patients with FMF and their relation to the main clinical features of the disease. ...
Fas and Fas ligand molecules play a central role in the apoptosis signaling of various cell types including neutrophils
Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection.
Fadel FI, et al. Transpl Immunol 2016. PMID 27109035
In this retrospective (Case-control) study, we examined the role of Fas -670A/G and Fas Ligand (FasL) -843C/T gene polymorphisms in allograft nephropathy in pediatric renal transplant recipients. METHODS: In 47 pediatric kidney transplant recipients and 20 healthy controls, Fas -670A/G and FasL -843C/T gene polymorphisms as well as serum soluble Fas Ligand level (sFasL) were measured. ...
In this retrospective (Case-control) study, we examined the role of Fas -670A/G and Fas Ligand (FasL) -843C/T gene poly …
CD95/Fas ligand mRNA is toxic to cells.
Putzbach W, et al. Elife 2018. PMID 30324908 Free PMC article.
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes (Putzbach et al., 2017). ...
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRN …
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy
Yamamoto TN, et al. J Clin Invest 2019. PMID 30694219 Free PMC article.
Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising T cell durability following ACT. We discovered that FASLG, the gene encoding the apoptosis-inducing ligand FasL, is overexpressed within the majority of human tumor microenvironments (TMEs). ...
Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising T cell durability fol …
A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway.
Du P, et al. Emerg Microbes Infect 2018. PMID 30061622 Free PMC article.
Lep-LPS promoted the expression and cytomembrane translocation of Fas and FasL in macrophages. The JNK and p38 MAPK but not ERK signaling pathways, as well as the transcription factors c-Jun and ATF2 but not CHOP, mediated Lep-LPS-induced Fas/FasL expression and translocation. ...Therefore, we demonstrated that a novel Fas-binding OMP and LPS of L. interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway....
Lep-LPS promoted the expression and cytomembrane translocation of Fas and FasL in macrophages. The JNK and p38 MAPK but not ERK signa …
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