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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 6
1995 32
1996 75
1997 112
1998 149
1999 166
2000 195
2001 197
2002 182
2003 163
2004 155
2005 134
2006 85
2007 19
2008 22
2009 25
2010 32
2011 23
2012 28
2013 25
2014 21
2015 30
2016 14
2017 19
2018 23
2019 5
2020 1
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1,872 results
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Long-term apoptosis-related protein expression in the diabetic mouse ovary.
Fraunhoffer NA, et al. PLoS One 2018. PMID 30192809 Free PMC article.
The main objective of the present study was to analyze the apoptosis pathways activated during follicular loss at multiple time points in a diabetic mouse model. ...Low BCL2 protein levels were detected in the diabetic mouse ovaries at all time points. This study describes for the first time the behavior of apoptosis-related proteins in the diabetic mouse ovary and shows not only that the FAS/FASL pathway contributes to follicular loss but also that antral follicles are the most affected....
The main objective of the present study was to analyze the apoptosis pathways activated during follicular loss at multiple time points in a …
Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300.
Otani T, et al. Cell Death Dis 2018. PMID 30546087 Free PMC article.
The activation of CREB and p300 resulted in increased expression of the transcription factor FoxO1 and consequent upregulation of Fas ligand (FasL) at the plasma membrane. The interaction of FasL with Fas on neighboring adipocytes triggered the phosphorylation at threonine-357/serine-358 and homotrimerization of mixed-lineage kinase domain-like protein (MLKL), a key regulator of necroptosis, as well as Ca(2+) influx via transient receptor potential melastatin 7 (TRPM7), the generation of reactive oxygen species and lipid peroxides, and dephosphorylation of dynamin-related protein 1 (DRP1) at serine-637, resulting in mitochondrial fragmentation. ...
The activation of CREB and p300 resulted in increased expression of the transcription factor FoxO1 and consequent upregulation of Fas ligand …
Mouse T cells engineered to display on their surface a novel form of FasL protein undergo apoptosis when stimulated with alloantigens: implications for graft-versus-host disease.
Yolcu ES and Singh NP. Transplant Proc 2013. PMID 23769056
METHODS: Inasmuch as Fas/FasL-induced apoptosis plays a critical role in self-tolerance, we tested whether the direct display of a novel form of FasL (SA-FasL) protein chimeric with streptavidin (SA) on the surface of T cells induces apoptosis in such cells in response to alloantigens. ...This effect was specific to SA-FasL; control SA protein-engineered T cells generated a potent proliferative alloresponse without significant apoptosis. ...
METHODS: Inasmuch as Fas/FasL-induced apoptosis plays a critical role in self-tolerance, we tested whether the direct display of a no …
CART cells are prone to Fas- and DR5-mediated cell death
Tschumi BO, et al. J Immunother Cancer 2018. PMID 30005714 Free PMC article.
Here, we demonstrate that CART cells progressively upregulate Fas, FasL, DR5 and TRAIL, which result in their programmed cell death, independently of antigen-mediated TCR or CAR activation. ...
Here, we demonstrate that CART cells progressively upregulate Fas, FasL, DR5 and TRAIL, which result in their programmed cell death, …
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation
Mande P, et al. J Clin Invest 2018. PMID 29889098 Free PMC article.
These mice are distinguished by a high frequency of OVA-specific Tbet+, IFN-γ+, and FasL-expressing Th1 cells as well as autoantibody-producing B cells. ...FasL was a key effector mechanism in the skin, as the transfer of FasL-deficient DO11gld T cells completely failed to elicit overt skin lesions. ...
These mice are distinguished by a high frequency of OVA-specific Tbet+, IFN-γ+, and FasL-expressing Th1 cells as well as autoantibody …
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity
Dupaul-Chicoine J, et al. Immunity 2015. PMID 26384545 Free article.
Instead, the inflammasome-IL-18 pathway impacted maturation of hepatic NK cells, surface expression of the death ligand FasL, and capacity to kill FasL-sensitive tumors. ...
Instead, the inflammasome-IL-18 pathway impacted maturation of hepatic NK cells, surface expression of the death ligand FasL, and cap …
Involvement of Fas/FasL pathway in the murine model of atopic dermatitis.
Bień K, et al. Inflamm Res 2017. PMID 28434120 Free PMC article.
OBJECTIVE AND DESIGN: The aim of this study was to elucidate the role of apoptosis mediated through Fas/FasL pathway using the mouse model of atopic dermatitis (AD). ...MRL-Faslpr/J (Fas-) and B6Smn.C3-Faslgld/J (FasL-) mouse strains. METHODS: Skin samples were subjected to staining for Fas/FasL expression, M30 epitope and assessment of inflammatory response via immunohistochemical staining. ...
OBJECTIVE AND DESIGN: The aim of this study was to elucidate the role of apoptosis mediated through Fas/FasL pathway using the mou
FasL incapacitation alleviates CD4(+) T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke.
Zhao H, et al. J Neuroimmunol 2018. PMID 29395324
Recent studies showed that Fas ligand (FasL) mutation could reduce post-stroke T cell invasion and microglia activation. In this study, we demonstrated that CD4(+) T cells could induce M1 microglia polarization through NF-κB signaling pathway, whereas FasL mutant CD4(+) T cells significantly reversed this effect. Besides, Th17/Treg cells balance was skewed into Treg cells after FasL mutation. In addition, conditioned medium from co-culture of FasL mutant CD4(+) T cells and microglia could alleviate neuronal injury. ...
Recent studies showed that Fas ligand (FasL) mutation could reduce post-stroke T cell invasion and microglia activation. In this stud …
[CTLA4-FasL protein for the prevention of immune rejection in mouse corneal transplantation].
Chen M, et al. Zhonghua Yan Ke Za Zhi 2008. PMID 18510245 Chinese.
OBJECTIVE: To investigate the therapeutic effect of double-functioned CTLA4-FasL protein for the prevention of immune rejection in murine corneal allografts. ...BALB/c mice accepted penetrating keratoplasty were randomly divided into 3 groups including no therapy (A), CsA DDS implanted in anterior chamber (B), 10 microg/mL CTLA4-FasL (C). ...
OBJECTIVE: To investigate the therapeutic effect of double-functioned CTLA4-FasL protein for the prevention of immune rejectio …
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