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2018 2
2019 1
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Intellectual functioning in clinically confirmed fetal valproate syndrome.
Bromley RL, Baker GA, Clayton-Smith J, Wood AG. Bromley RL, et al. Neurotoxicol Teratol. 2019 Jan-Feb;71:16-21. doi: 10.1016/j.ntt.2018.11.003. Epub 2018 Nov 16. Neurotoxicol Teratol. 2019. PMID: 30453023
BACKGROUND: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS). METHODS: This cross sectional obser
BACKGROUND: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not p …
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD. Glover SJ, et al. Ophthalmology. 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. Ophthalmology. 2002. PMID: 11986102
PURPOSE: To report the prevalence of ocular abnormalities in a group of children diagnosed with fetal anticonvulsant (FAC) syndrome(s). DESIGN: Retrospective, observational, noncomparative case series. ...CONCLUSIONS: We conclude that (1) abnormal opht …
PURPOSE: To report the prevalence of ocular abnormalities in a group of children diagnosed with fetal anticonvulsant (FAC) …
Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study.
Mawer G, Briggs M, Baker GA, Bromley R, Coyle H, Eatock J, Kerr L, Kini U, Kuzmyshcheva L, Lucas SB, Wyatt L, Clayton-Smith J; Liverpool & Manchester Neurodevelopment Group. Mawer G, et al. Seizure. 2010 Mar;19(2):112-9. doi: 10.1016/j.seizure.2009.11.008. Epub 2009 Dec 24. Seizure. 2010. PMID: 20036166 Free PMC article.
PURPOSE: To determine the influence of epilepsy and its treatment on pregnancy and its outcome. DESIGN: Controlled, observational study. SETTING: National Health Service maternity hospitals in Liverpool and Manchester regions. ...There were more major congenital malformati …
PURPOSE: To determine the influence of epilepsy and its treatment on pregnancy and its outcome. DESIGN: Controlled, observational stu …
Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years.
Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) Study Group. Meador KJ, et al. JAMA Pediatr. 2014 Aug;168(8):729-36. doi: 10.1001/jamapediatrics.2014.118. JAMA Pediatr. 2014. PMID: 24934501 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: Prospective observational multicenter study of long-term neurodevelopmental effects of AED use. ...CONCLUSIONS AND RELEVANCE: No adverse effects of AED exposure via breast milk were observed at age 6 years, consistent with another …
DESIGN, SETTING, AND PARTICIPANTS: Prospective observational multicenter study of long-term neurodevelopmental effects of AED use. .. …
Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations.
Kinney MO, Morrow J, Patterson CC, Campbell E, Russell A, Smithson HW, Parsons L, Morrison PJ, Bromley R, Liggan B, Delanty N, Irwin B, Hunt SJ, Craig JJ. Kinney MO, et al. J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1320-1323. doi: 10.1136/jnnp-2017-317368. Epub 2018 Apr 16. J Neurol Neurosurg Psychiatry. 2018. PMID: 29661925
METHODS: The UK and Ireland Epilepsy and Pregnancy Register, a prospective, observational, registration and follow-up study established in 1996, was used to determine the changes in antiepileptic drugs (AEDs) utilised during pregnancy and the MCM rate between 1996 and 2016 …
METHODS: The UK and Ireland Epilepsy and Pregnancy Register, a prospective, observational, registration and follow-up study establish …
Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort.
Charlton RA, McGrogan A, Snowball J, Yates LM, Wood A, Clayton-Smith J, Smithson WH, Richardson JL, McHugh N, Thomas SH, Baker GA, Bromley R. Charlton RA, et al. Drug Saf. 2017 May;40(5):387-397. doi: 10.1007/s40264-017-0506-5. Drug Saf. 2017. PMID: 28188601 Free PMC article.
INTRODUCTION: Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. ...NDD prevalence differed …
INTRODUCTION: Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data …