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Fetal valproate syndrome: the Irish experience.
Mohd Yunos H, Green A. Mohd Yunos H, et al. Ir J Med Sci. 2018 Nov;187(4):965-968. doi: 10.1007/s11845-018-1757-6. Epub 2018 Feb 3. Ir J Med Sci. 2018. PMID: 29396778
INTRODUCTION: Fetal valproate syndrome was first described in 1984. Valproic acid crosses the placenta and can potentially lead to major congenital malformation, dysmorphism and neurodevelopmental disorder. METHODS: A retrospective study of 29 cases of FVS diagnosed …
INTRODUCTION: Fetal valproate syndrome was first described in 1984. Valproic acid crosses the placenta and can potentially lea …
Intellectual functioning in clinically confirmed fetal valproate syndrome.
Bromley RL, Baker GA, Clayton-Smith J, Wood AG. Bromley RL, et al. Neurotoxicol Teratol. 2019 Jan-Feb;71:16-21. doi: 10.1016/j.ntt.2018.11.003. Epub 2018 Nov 16. Neurotoxicol Teratol. 2019. PMID: 30453023
BACKGROUND: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS). METHODS: This cross sectional observat …
BACKGROUND: An increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not p …
Characteristics of fetal anticonvulsant syndrome associated autistic disorder.
Rasalam AD, Hailey H, Williams JH, Moore SJ, Turnpenny PD, Lloyd DJ, Dean JC. Rasalam AD, et al. Dev Med Child Neurol. 2005 Aug;47(8):551-5. doi: 10.1017/s0012162205001076. Dev Med Child Neurol. 2005. PMID: 16108456 Free article.
The aim of this study was to evaluate the clinical features and frequency of autistic disorder or Asperger syndrome (AS; according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV] criteria) in children exposed to anticonvulsant medicati …
The aim of this study was to evaluate the clinical features and frequency of autistic disorder or Asperger syndrome (AS; according to …
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Glover SJ, Quinn AG, Barter P, Hart J, Moore SJ, Dean JC, Turnpenny PD. Glover SJ, et al. Ophthalmology. 2002 May;109(5):942-7. doi: 10.1016/s0161-6420(02)00959-4. Ophthalmology. 2002. PMID: 11986102
PURPOSE: To report the prevalence of ocular abnormalities in a group of children diagnosed with fetal anticonvulsant (FAC) syndrome(s). DESIGN: Retrospective, observational, noncomparative case series. ...CONCLUSIONS: We conclude that (1) abnormal ophthalmic …
PURPOSE: To report the prevalence of ocular abnormalities in a group of children diagnosed with fetal anticonvulsant (FAC) …
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes.
Jackson A, Ward H, Bromley RL, Deshpande C, Vasudevan P, Scurr I, Dean J, Shannon N, Berg J, Holder S, Baralle D, Clayton-Smith J; DDD Study. Jackson A, et al. Arch Dis Child. 2020 Apr;105(4):384-389. doi: 10.1136/archdischild-2018-316547. Epub 2019 Sep 3. Arch Dis Child. 2020. PMID: 31481360
INTRODUCTION: Fetal anticonvulsant syndrome (FACS) describes the pattern of physical and developmental problems seen in those children exposed to certain antiepileptic drugs (AEDs) in utero. ...
INTRODUCTION: Fetal anticonvulsant syndrome (FACS) describes the pattern of physical and developmental problems seen in …
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J; Liverpool and Manchester Neurodevelopmental Study Group. Kini U, et al. Arch Dis Child Fetal Neonatal Ed. 2006 Mar;91(2):F90-5. doi: 10.1136/adc.2004.067421. Epub 2005 Oct 20. Arch Dis Child Fetal Neonatal Ed. 2006. PMID: 16239295 Free PMC article.
Nearly half (45%) of unexposed children had some of the facial features associated with AED exposure, showing that many of these features may be seen as part of normal variation and that the diagnosis of the fetal anticonvulsant syndrome is difficult to make …
Nearly half (45%) of unexposed children had some of the facial features associated with AED exposure, showing that many of these features ma …
A clinical study of 57 children with fetal anticonvulsant syndromes.
Moore SJ, Turnpenny P, Quinn A, Glover S, Lloyd DJ, Montgomery T, Dean JC. Moore SJ, et al. J Med Genet. 2000 Jul;37(7):489-97. doi: 10.1136/jmg.37.7.489. J Med Genet. 2000. PMID: 10882750 Free PMC article.
To evaluate the pattern of abnormalities associated with prenatal anticonvulsant exposure further, we undertook a clinical study of 57 children with fetal anticonvulsant syndromes. METHODS: Fifty two children were ascertained through the Fetal Antic
To evaluate the pattern of abnormalities associated with prenatal anticonvulsant exposure further, we undertook a clinical study of 5 …
Developing diagnostic criteria for the fetal anticonvulsant syndromes.
Dean JC, Moore SJ, Turnpenny PD. Dean JC, et al. Seizure. 2000 Apr;9(3):233-4. doi: 10.1053/seiz.2000.0392. Seizure. 2000. PMID: 10775521 Free article.
We describe a set of diagnostic criteria which may assist in defining which children are likely to have a fetal anticonvulsant syndrome. This may help future research to identify risk factors which predispose to an adverse fetal outcome....
We describe a set of diagnostic criteria which may assist in defining which children are likely to have a fetal anticonvulsant
Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort.
Charlton RA, McGrogan A, Snowball J, Yates LM, Wood A, Clayton-Smith J, Smithson WH, Richardson JL, McHugh N, Thomas SH, Baker GA, Bromley R. Charlton RA, et al. Drug Saf. 2017 May;40(5):387-397. doi: 10.1007/s40264-017-0506-5. Drug Saf. 2017. PMID: 28188601 Free PMC article.
Intracranial arteriovenous malformation with maternal carbamazepine use.
Narang M, Shah D, Natasha G. Narang M, et al. Indian J Pediatr. 2007 Jan;74(1):85-6. doi: 10.1007/s12098-007-0035-9. Indian J Pediatr. 2007. PMID: 17264463
This case suggests that development of arteriovenous malformation in a child with maternal carbamazepine therapy may occur as a part of clinical profile of 'fetal anticonvulsant syndrome'....
This case suggests that development of arteriovenous malformation in a child with maternal carbamazepine therapy may occur as a part of clin …