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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 12
1947 21
1948 15
1949 19
1950 30
1951 49
1952 49
1953 54
1954 79
1955 104
1956 127
1957 125
1958 69
1959 66
1960 73
1961 93
1962 98
1963 243
1964 361
1965 263
1966 245
1967 373
1968 454
1969 553
1970 505
1971 662
1972 698
1973 786
1974 779
1975 704
1976 525
1977 504
1978 451
1979 470
1980 449
1981 466
1982 429
1983 589
1984 561
1985 635
1986 604
1987 552
1988 573
1989 568
1990 529
1991 564
1992 564
1993 564
1994 561
1995 551
1996 556
1997 546
1998 516
1999 512
2000 563
2001 619
2002 600
2003 619
2004 616
2005 670
2006 656
2007 686
2008 715
2009 732
2010 714
2011 714
2012 756
2013 813
2014 817
2015 747
2016 673
2017 607
2018 516
2019 310
2020 5
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32,279 results
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Page 1
Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review.
Peng HT, et al. Biomed Res Int 2018 - Review. PMID 30596098 Free PMC article.
Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding. Both Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) have been increasingly used to diagnose fibrinogen deficiency and guide fibrinogen transfusion in trauma and surgical bleeding patients. ...TEG and ROTEM functional fibrinogen tests play important roles in the diagnosis of fibrinogen-related coagulopathy and guidance of transfusion requirements. ...
Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding. Both Thromboelastography (TEG) and Rot
Fibrinogen for the management of critical obstetric hemorrhage.
Matsunaga S, et al. J Obstet Gynaecol Res 2019 - Review. PMID 30155944 Free PMC article.
Especially, we performed a systematic review on target value of fibrinogen for hemostasis and effectiveness of fibrinogen concentrate. ...RESULTS: The target value of fibrinogen calculated by needs for massive transfusion was 200 mg/dL or 10 mm of A5(FIBTEM) . Although fibrinogen concentrate worked poorly on fibrinogen levels within the normal range, it improved the blood fibrinogen levels rapidly when it was administered to critical obstetric hemorrhage patients with serious hypofibrinogenemia. ...
Especially, we performed a systematic review on target value of fibrinogen for hemostasis and effectiveness of fibrinogen conc …
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Merlini M, et al. Neuron 2019. PMID 30737131 Free PMC article.
Fibrinogen-induced spine elimination was prevented by inhibiting reactive oxygen species (ROS) generation or genetic ablation of CD11b. Genetic elimination of the fibrinogen binding motif to CD11b reduced neuroinflammation, synaptic deficits, and cognitive decline in the 5XFAD mouse model of AD. ...
Fibrinogen-induced spine elimination was prevented by inhibiting reactive oxygen species (ROS) generation or genetic ablation of CD11
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3.
Wang J, et al. Cell 2019. PMID 30580966 Free PMC article.
Here, we demonstrate that fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. ...
Here, we demonstrate that fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent …
Human Fibrinogen: Molecular and Genetic Aspects of Congenital Disorders.
Tiscia GL and Margaglione M. Int J Mol Sci 2018 - Review. PMID 29844251 Free PMC article.
Congenital fibrinogen disorders can be quantitative (afibrinogenemia, hypofibrinogenemia) or functional (dysfibrinognemia). To date, several genetic variants have been identified in individuals with fibrinogen disorders. ...In this review, some aspects concerning molecular and clinical findings available on congenital fibrinogen disorders will be discussed....
Congenital fibrinogen disorders can be quantitative (afibrinogenemia, hypofibrinogenemia) or functional (dysfibrinognemia). To date, …
Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial.
Curry N, et al. Crit Care 2018 - Clinical Trial. PMID 29914530 Free PMC article.
The aims of this pragmatic study were to assess the feasibility of fibrinogen concentrate administration within 45 minutes of hospital admission and to quantify efficacy in maintaining fibrinogen levels ≥ 2 g/L during active haemorrhage. ...Fibrinogen levels in the fibrinogen concentrate (FgC) arm rose by a mean of 0.9 g/L (SD, 0.5) compared with a reduction of 0.2 g/L (SD, 0.5) in the placebo arm and were significantly higher in the FgC arm (p < 0.0001) at 2 hours. ...
The aims of this pragmatic study were to assess the feasibility of fibrinogen concentrate administration within 45 minutes of hospita …
Fibrinogen Concentrate in Cardiovascular Surgery: A Meta-analysis of Randomized Controlled Trials.
Li JY, et al. Anesth Analg 2018. PMID 29863608
Although the transfusion of fibrinogen concentrate has been increasing, potential benefits and risks associated with perioperative fibrinogen supplementation in cardiovascular surgery are not fully understood. ...Subgroup analyses by fibrinogen dose and by baseline risk for bleeding were preplanned. RESULTS: A total of 8 RCTs of fibrinogen concentrate in adults (n = 597) of mixed risk or high risk undergoing cardiovascular surgery were included. ...
Although the transfusion of fibrinogen concentrate has been increasing, potential benefits and risks associated with perioperative …
AGA Clinical Practice Update: Coagulation in Cirrhosis
O'Leary JG, et al. Gastroenterology 2019 - Review. PMID 30986390
BEST PRACTICE ADVICE 4: The following transfusion thresholds for management of active bleeding or high-risk procedures may optimize clot formation in advanced liver disease: hematocrit ≥25%, platelet count >50,000, and fibrinogen >120 mg/dL. ...
BEST PRACTICE ADVICE 4: The following transfusion thresholds for management of active bleeding or high-risk procedures may optimize clot for …
A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma.
Xu Q, et al. J Immunol Res 2018. PMID 30027102 Free PMC article.
Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection. ...Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ(2) test. ...
Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrin
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