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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 3
1965 21
1966 54
1967 79
1968 96
1969 134
1970 213
1971 284
1972 386
1973 449
1974 488
1975 503
1976 445
1977 576
1978 494
1979 597
1980 618
1981 710
1982 759
1983 785
1984 844
1985 941
1986 872
1987 855
1988 823
1989 904
1990 1048
1991 955
1992 956
1993 1012
1994 1092
1995 1091
1996 1057
1997 1012
1998 1216
1999 1230
2000 1339
2001 1495
2002 1581
2003 1762
2004 1928
2005 1903
2006 2028
2007 2048
2008 2178
2009 2284
2010 2460
2011 2687
2012 2833
2013 2915
2014 2730
2015 2745
2016 2787
2017 2825
2018 2588
2019 1062
2020 13
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62,971 results
Results by year
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Page 1
Fibroblasts in cancer.
Kalluri R and Zeisberg M. Nat Rev Cancer 2006 - Review. PMID 16572188
Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. ...Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies....
Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions t
The Pancreatic Cancer Microenvironment
Dougan SK. Cancer J 2017 - Review. PMID 29189327
Pancreatic ductal adenocarcinoma (PDAC) is composed of a minority of malignant cells within a microenvironment of extracellular matrix, fibroblasts, endothelial cells, and immune cells. ...
Pancreatic ductal adenocarcinoma (PDAC) is composed of a minority of malignant cells within a microenvironment of extracellular matrix, f
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.
Affo S, et al. Annu Rev Pathol 2017 - Review. PMID 27959632 Free PMC article.
Cholangiocarcinoma (CCA), in contrast, is characterized by a strong desmoplasia that typically occurs in response to the tumor, suggesting a key role of cancer-associated fibroblasts (CAFs) and fibrosis in its tumor microenvironment (TME). ...
Cholangiocarcinoma (CCA), in contrast, is characterized by a strong desmoplasia that typically occurs in response to the tumor, suggesting a …
Cardiac Fibrosis: The Fibroblast Awakens.
Travers JG, et al. Circ Res 2016 - Review. PMID 26987915 Free PMC article.
Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis. ...This review summarizes current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis....
Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; …
TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases
Pardali E, et al. Int J Mol Sci 2017 - Review. PMID 29039786 Free PMC article.
Myofibroblasts have been identified as the cells responsible for the progression of the fibrotic process, and they originate from several sources, including quiescent tissue fibroblasts, circulating CD34⁺ fibrocytes and the phenotypic conversion of various cell types into activated myofibroblasts. ...Transforming growth factor β (TGF-β) has a central role in fibrogenesis by modulating the fibroblast phenotype and function, inducing myofibroblast transdifferentiation and promoting matrix accumulation. ...
Myofibroblasts have been identified as the cells responsible for the progression of the fibrotic process, and they originate from several so …
Protocol for effective differentiation of 3T3-L1 cells to adipocytes
Zebisch K, et al. Anal Biochem 2012. PMID 22425542
Due to their potential to differentiate from fibroblasts to adipocytes, 3T3-L1 cells are widely used for studying adipogenesis and the biochemistry of adipocytes. ...
Due to their potential to differentiate from fibroblasts to adipocytes, 3T3-L1 cells are widely used for studying adipogenesis and th …
Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells.
Sazeides C and Le A. Adv Exp Med Biol 2018 - Review. PMID 29946782
Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. ...The TME is a heterogeneous environment consisting of fibroblasts, tumor-associated macrophages, adipocytes, an extracellular matrix, and mesenchymal stem cells [4]. ...
Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiat …
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
Frangogiannis NG. Mol Aspects Med 2019 - Review. PMID 30056242
Several other cell types, including cardiomyocytes, endothelial cells, pericytes, macrophages, lymphocytes and mast cells may contribute to the fibrotic process, by producing proteases that participate in matrix metabolism, by secreting fibrogenic mediators and matricellular proteins, or by exerting contact-dependent actions on fibroblast phenotype. ...Secreted fibrogenic mediators and matricellular proteins bind to cell surface receptors in fibroblasts, such as cytokine receptors, integrins, syndecans and CD44, and transduce intracellular signaling cascades that regulate genes involved in synthesis, processing and metabolism of the extracellular matrix. ...
Several other cell types, including cardiomyocytes, endothelial cells, pericytes, macrophages, lymphocytes and mast cells may contribute to …
Intestinal fibrosis
Lenti MV and Di Sabatino A. Mol Aspects Med 2019 - Review. PMID 30385174
., myofibroblasts, fibroblasts) and immune (i.e., monocytes, macrophages, T-cells) cells, the interactions of which are crucial in the progressive tissue remodeling and destroy. ...
., myofibroblasts, fibroblasts) and immune (i.e., monocytes, macrophages, T-cells) cells, the interactions of which are crucial in th …
Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis.
Pardo A and Selman M. Ann Am Thorac Soc 2016 - Review. PMID 28005427
The hallmarks of IPF are aberrant activation of alveolar epithelial cells and accumulation of fibroblasts and myofibroblasts along with excessive production of extracellular matrix. ...Also, aging seems to confer a profibrotic phenotype upon fibroblasts and to increase the severity of the fibrogenic response in non-IPF fibrotic lung disorders. ...
The hallmarks of IPF are aberrant activation of alveolar epithelial cells and accumulation of fibroblasts and myofibroblasts along wi …
62,971 results
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