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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 2
1967 1
1968 2
1969 2
1970 1
1972 1
1973 1
1974 2
1975 4
1976 6
1977 2
1978 4
1979 5
1980 5
1981 7
1982 11
1983 10
1984 6
1985 14
1986 8
1987 20
1988 7
1989 21
1990 19
1991 32
1992 23
1993 22
1994 26
1995 24
1996 17
1997 37
1998 26
1999 46
2000 56
2001 54
2002 52
2003 64
2004 101
2005 83
2006 98
2007 84
2008 86
2009 140
2010 149
2011 185
2012 223
2013 223
2014 213
2015 239
2016 258
2017 261
2018 310
2019 129
2020 3
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3,056 results
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Page 1
Fibroblasts in cancer.
Kalluri R and Zeisberg M. Nat Rev Cancer 2006 - Review. PMID 16572188
Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions to this process are beginning to emerge. ...Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies....
Fibroblasts are associated with cancer cells at all stages of cancer progression, and their structural and functional contributions t
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer.
Affo S, et al. Annu Rev Pathol 2017 - Review. PMID 27959632 Free PMC article.
Cholangiocarcinoma (CCA), in contrast, is characterized by a strong desmoplasia that typically occurs in response to the tumor, suggesting a key role of cancer-associated fibroblasts (CAFs) and fibrosis in its tumor microenvironment (TME). ...
Cholangiocarcinoma (CCA), in contrast, is characterized by a strong desmoplasia that typically occurs in response to the tumor, suggesting a …
Turning foes to friends: targeting cancer-associated fibroblasts.
Chen X and Song E. Nat Rev Drug Discov 2019 - Review. PMID 30470818
Among all the stromal cells that populate the tumour microenvironment, cancer-associated fibroblasts (CAFs) are the most abundant and are critically involved in cancer progression. ...
Among all the stromal cells that populate the tumour microenvironment, cancer-associated fibroblasts (CAFs) are the most abundant and …
Cardiac Fibrosis: The Fibroblast Awakens.
Travers JG, et al. Circ Res 2016 - Review. PMID 26987915 Free PMC article.
Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis. ...This review summarizes current knowledge regarding the origins and roles of fibroblasts, mediators and signaling pathways known to influence fibroblast function after myocardial injury, as well as novel therapeutic strategies under investigation to attenuate cardiac fibrosis....
Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; …
Distinct fibroblast subsets drive inflammation and damage in arthritis.
Croft AP, et al. Nature 2019. PMID 31142839 Free PMC article.
We show that deletion of fibroblast activation protein-α (FAPα)(+) fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis. Single-cell transcriptional analysis identified two distinct fibroblast subsets within the FAPα(+) population: FAPα(+)THY1(+) immune effector fibroblasts located in the synovial sub-lining, and FAPα(+)THY1(-) destructive fibroblasts restricted to the synovial lining layer. ...
We show that deletion of fibroblast activation protein-α (FAPα)(+) fibroblasts suppressed both inflammation and bone erosions …
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Alkasalias T, et al. Int J Mol Sci 2018 - Review. PMID 29883428 Free PMC article.
A tumor cell-induced switch of normal fibroblasts into cancer-associated fibroblasts (CAFs), in turn, triggers a range of pro-tumorigenic signals accompanied by distraction of the normal tissue architecture, thus creating an optimal niche for cancer cells to grow extensively. ...These paradoxical tumor suppressive and promoting actions of fibroblasts are the focus of this review, highlighting the heterogenic molecular properties of both normal and cancer-associated fibroblasts, as well as their main mechanisms of action, including the emerging impact on immunomodulation and different therapy responses....
A tumor cell-induced switch of normal fibroblasts into cancer-associated fibroblasts (CAFs), in turn, triggers a range of pro- …
Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis.
Xie T, et al. Cell Rep 2018. PMID 29590628 Free PMC article.
Fibroblast heterogeneity has long been recognized in mouse and human lungs, homeostasis, and disease states. However, there is no common consensus on fibroblast subtypes, lineages, biological properties, signaling, and plasticity, which severely hampers our understanding of the mechanisms of fibrosis. ...This collection of single-cell transcriptomes and the distinct classification of fibroblast subsets provide a new resource for understanding the fibroblast landscape and the roles of fibroblasts in fibrotic diseases....
Fibroblast heterogeneity has long been recognized in mouse and human lungs, homeostasis, and disease states. However, there is no com
A peek into cancer-associated fibroblasts: origins, functions and translational impact.
LeBleu VS and Kalluri R. Dis Model Mech 2018 - Review. PMID 29686035 Free PMC article.
Among the host stromal constituents associated with the tumor are cancer-associated fibroblasts, a highly abundant and heterogeneous population of cells of mesenchymal lineage. ...Taken together, this suggests a putative bimodal function for cancer-associated fibroblasts in oncogenesis. As illustrated in this Review and its accompanying poster, cancer-associated fibroblasts are a dynamic component of the tumor microenvironment that orchestrates the interplay between the cancer cells and the host stromal response. ...
Among the host stromal constituents associated with the tumor are cancer-associated fibroblasts, a highly abundant and heterogeneous …
The role of stromal cancer-associated fibroblasts in pancreatic cancer.
von Ahrens D, et al. J Hematol Oncol 2017 - Review. PMID 28351381 Free PMC article.
Cancer-associated fibroblasts (CAFs) are cellular components of the desmoplastic stroma characteristic to the tumor that contributes to this treatment resistance. ...
Cancer-associated fibroblasts (CAFs) are cellular components of the desmoplastic stroma characteristic to the tumor that contributes …
Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment.
Houthuijzen JM and Jonkers J. Cancer Metastasis Rev 2018 - Review. PMID 30465162
Fibroblasts are one of the largest populations of non-malignant host cells that can be found within the TME of breast, pancreatic, and prostate tumors. Substantial scientific evidence has shown that these cancer-associated fibroblasts (CAFs) are not only associated with tumors by proximity but are also actively recruited to developing tumors where they can influence other cells of the TME as well as influencing tumor cell survival and metastasis. ...
Fibroblasts are one of the largest populations of non-malignant host cells that can be found within the TME of breast, pancreatic, an
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