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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 3
1965 19
1966 43
1967 56
1968 67
1969 85
1970 135
1971 185
1972 227
1973 197
1974 199
1975 210
1976 159
1977 178
1978 169
1979 185
1980 150
1981 190
1982 185
1983 204
1984 184
1985 245
1986 214
1987 237
1988 254
1989 315
1990 268
1991 252
1992 293
1993 262
1994 286
1995 264
1996 246
1997 216
1998 261
1999 355
2000 380
2001 489
2002 511
2003 641
2004 736
2005 723
2006 809
2007 877
2008 868
2009 903
2010 975
2011 1039
2012 1062
2013 1133
2014 1158
2015 1202
2016 1193
2017 1181
2018 1087
2019 415
2020 4
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22,422 results
Results by year
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Page 1
The biology and function of fibroblasts in cancer.
Kalluri R. Nat Rev Cancer 2016 - Review. PMID 27550820
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. ...Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells. ...
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal …
Redefining the identity of cardiac fibroblasts.
Tallquist MD and Molkentin JD. Nat Rev Cardiol 2017 - Review. PMID 28436487 Free PMC article.
Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under physiological conditions. In the adult heart, activated cardiac fibroblasts also participate in the healing response after acute myocardial infarction and during chronic disease states characterized by augmented interstitial fibrosis and ventricular remodelling. However, delineation of the characteristics, plasticity, and origins of cardiac fibroblasts is an area of ongoing investigation and controversy. ...
Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under physiological conditions. In the adult h …
Wound healing and the role of fibroblasts.
Bainbridge P. J Wound Care 2013 - Review. PMID 23924840
This article explores and summarises the research evidence on the role of fibroblasts, their origins and activation, and how they navigate the wound bed, as well as how their activity leads to wound contraction. This article also explores the local conditions at the wound site, which activate, regulate and ultimately reduce the fibroblast activity as the skin's integrity returns on healing....
This article explores and summarises the research evidence on the role of fibroblasts, their origins and activation, and how they nav …
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging.
Salzer MC, et al. Cell 2018. PMID 30415840 Free article.
We show that the identity of old fibroblasts becomes undefined, with the fibroblast states present in young skin no longer clearly demarcated. In addition, old fibroblasts not only reduce the expression of genes involved in the formation of the extracellular matrix, but also gain adipogenic traits, paradoxically becoming more similar to neonatal pro-adipogenic fibroblasts. ...
We show that the identity of old fibroblasts becomes undefined, with the fibroblast states present in young skin no longer cle …
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek JJ, et al. Nat Rev Mol Cell Biol 2002 - Review. PMID 11988769
During the past 20 years, it has become generally accepted that the modulation of fibroblastic cells towards the myofibroblastic phenotype, with acquisition of specialized contractile features, is essential for connective-tissue remodelling during normal and pathological wound healing. ...
During the past 20 years, it has become generally accepted that the modulation of fibroblastic cells towards the myofibroblastic phen …
Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts.
Avagliano A, et al. Biomed Res Int 2018 - Review. PMID 29967776 Free PMC article.
Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour microenvironment and undergo an activation process associated with secretion of growth factors, cytokines, and paracrine interactions. ...
Cancer associated fibroblasts (CAFs) are the main stromal cell type of solid tumour microenvironment and undergo an activation proces …
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out
Zent J and Guo LW. Cell Physiol Biochem 2018 - Review. PMID 30184544 Free PMC article.
Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally defined by acquired contractile function and high synthetic ability to produce extracellular matrix (ECM). ...
Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally define …
Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart.
Sánchez-Iranzo H, et al. Proc Natl Acad Sci U S A 2018. PMID 29610343 Free PMC article.
Using novel genetic tools to mark periostin b- and collagen 1alpha2 (col1a2)-expressing cells in combination with transcriptome analysis, we explored the sources of activated fibroblasts and traced their fate. ...We conclude that ECM-producing cells are key players in the regenerative process and suggest that antifibrotic therapies might be less efficient than strategies targeting fibroblast inactivation....
Using novel genetic tools to mark periostin b- and collagen 1alpha2 (col1a2)-expressing cells in combination with transcriptome analysis, we …
Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.
Martinez-Outschoorn UE, et al. Semin Cancer Biol 2014 - Review. PMID 24486645
Fibroblasts are the most abundant "non-cancerous" cells in tumors. However, it remains largely unknown how these cancer-associated fibroblasts (CAFs) promote tumor growth and metastasis, driving chemotherapy resistance and poor clinical outcome. ...Mechanistically, this occurs via HIF1-alpha and NFκB signaling, driving oxidative stress, autophagy, glycolysis and senescence in stromal fibroblasts. ...
Fibroblasts are the most abundant "non-cancerous" cells in tumors. However, it remains largely unknown how these cancer-associated
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