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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 31
1946 119
1947 166
1948 176
1949 172
1950 286
1951 391
1952 457
1953 412
1954 417
1955 468
1956 481
1957 466
1958 447
1959 458
1960 497
1961 586
1962 645
1963 1172
1964 1442
1965 980
1966 1045
1967 1223
1968 1436
1969 1508
1970 1448
1971 1514
1972 1597
1973 1636
1974 1564
1975 1428
1976 1348
1977 1250
1978 1262
1979 1313
1980 1336
1981 1279
1982 1431
1983 1481
1984 1503
1985 1665
1986 1645
1987 1719
1988 1819
1989 1969
1990 2099
1991 2050
1992 2070
1993 2186
1994 2320
1995 2366
1996 2280
1997 2376
1998 2391
1999 2564
2000 2535
2001 2650
2002 2897
2003 3179
2004 3348
2005 3787
2006 3943
2007 4221
2008 4855
2009 4912
2010 5357
2011 5702
2012 6156
2013 6419
2014 6817
2015 7238
2016 7274
2017 7221
2018 7182
2019 3443
2020 65
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156,897 results
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Page 1
Mechanisms of fibrosis: therapeutic translation for fibrotic disease.
Wynn TA and Ramalingam TR. Nat Med 2012 - Review. PMID 22772564 Free PMC article.
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulation of excess extracellular matrix components. ...Fibrosis affects nearly every tissue in the body. Here we discuss how key components of the innate and adaptive immune response contribute to the pathogenesis of fibrosis. ...
Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or scarring, is defined by the accumulatio
Idiopathic Retroperitoneal Fibrosis.
Vaglio A and Maritati F. J Am Soc Nephrol 2016 - Review. PMID 26860343 Free PMC article.
Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal aorta and the iliac arteries, and spreads into the adjacent retroperitoneum, where it frequently causes ureteral obstruction and renal failure. ...
Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal a …
Ovarian Fibrosis: A Phenomenon of Concern.
Zhou F, et al. Chin Med J (Engl) 2017 - Review. PMID 28139522 Free PMC article.
This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian diseases and fibrosis. ...STUDY SELECTION: Articles were obtained and reviewed to analyze the pathogenic mechanism of ovarian fibrosis and related ovarian diseases. ...
This review aimed to investigate the pathogenetic mechanism of ovarian fibrosis and to clarify the relationship between ovarian disea …
Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models and Therapeutic Strategies.
Nogueira A, et al. In Vivo 2017 - Review. PMID 28064215 Free PMC article.
There are many molecules and cells that are associated with progression of renal fibrosis e.g. angiotensin II (Ang II). Therefore, in order to understand the biopathology of renal fibrosis and for the evaluation of new treatments, the use of animal models is crucial such as: surgical, chemical and physical models, spontaneous models, genetic models and in vitro models. However, there are currently no effective treatments for preventing the progression of renal fibrosis. Therefore it is essential to improve our knowledge of the cellular and molecular mechanisms of the progress of renal fibrosis in order to achieve a reversion/elimination of renal fibrosis....
There are many molecules and cells that are associated with progression of renal fibrosis e.g. angiotensin II (Ang II). Therefore, in …
The good and the bad collagens of fibrosis - Their role in signaling and organ function.
Karsdal MA, et al. Adv Drug Deliv Rev 2017 - Review. PMID 28736303
However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibrosis due to viral versus cholestatic, autoimmune or toxic liver injury, with reticular, chicken wire and bridging fibrosis. ...Consequently, to adequately assess fibrosis and to design optimal antifibrotic therapies, we need to dissect the molecular entity of fibrosis for the molecular composition and spatial distribution of collagens and the associated ECM....
However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibros
Human Fibrotic Diseases: Current Challenges in Fibrosis Research.
Rosenbloom J, et al. Methods Mol Biol 2017 - Review. PMID 28836191
The fibrotic disorders encompass a wide spectrum of clinical entities including systemic fibrotic diseases such as systemic sclerosis (SSc), sclerodermatous graft vs. host disease, and nephrogenic systemic fibrosis, as well as numerous organ-specific disorders including radiation-induced fibrosis and cardiac, pulmonary, liver, and kidney fibrosis. ...Here, we briefly review the current knowledge of the molecular mechanisms involved in the development of tissue fibrosis and point out some of the most important challenges to research in the fibrotic diseases and to the development of effective therapeutic approaches for this often fatal group of disorders. ...
The fibrotic disorders encompass a wide spectrum of clinical entities including systemic fibrotic diseases such as systemic sclerosis (SSc), …
Circular RNAs in Organ Fibrosis.
Yao J, et al. Adv Exp Med Biol 2018 - Review. PMID 30259373
Emerging evidence has shown that circRNA is related to fibrosis activity and could potentially be a monitoring factor for fibrosis or, more excitingly, could be a target for treatment. In this chapter, we will first present the basic mechanism of organ fibrosis. Then we will focus on the recent studies about how circRNA dysregulation contributes to organ fibrosis. ...
Emerging evidence has shown that circRNA is related to fibrosis activity and could potentially be a monitoring factor for fibrosis
Idiopathic retroperitoneal fibrosis and its overlap with IgG4-related disease.
Rossi GM, et al. Intern Emerg Med 2017 - Review. PMID 28070877
Retroperitoneal fibrosis (RPF) is a rare disease characterised by fibrous tissue proliferation in the retroperitoneum, with encasement of the ureters and large vessels of the abdomen as the most destructive of potentially severe complications. ...Among these, together with sclerosing pancreatitis and cholangitis, pseudotumour of the orbit, idiopathic mediastinal fibrosis and other conditions, is idiopathic retroperitoneal fibrosis (IRF). ...
Retroperitoneal fibrosis (RPF) is a rare disease characterised by fibrous tissue proliferation in the retroperitoneum, with encasemen …
Molecular imaging of fibrosis: recent advances and future directions.
Montesi SB, et al. J Clin Invest 2019 - Review. PMID 30601139 Free PMC article.
The few available antifibrotic treatments modify the rate of fibrosis progression, but there are no available treatments to reverse established fibrosis. ...Here we review currently available molecular imaging probes for detecting fibrosis and fibrogenesis, the active formation of new fibrous tissue, and their application to models of fibrosis across organ systems and fibrotic processes. ...
The few available antifibrotic treatments modify the rate of fibrosis progression, but there are no available treatments to reverse e …
156,897 results
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