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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 3
2006 1
2009 3
2010 1
2012 1
2013 1
2014 2
2015 2
2016 1
2017 2
2019 2
2020 1
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21 results
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Page 1
Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, Goodale A, Lee Y, Bagul M, Liao R, Navarro A, Yuan TL, Ng RWS, Raghavan S, Gray NS, Tsherniak A, Vazquez F, Root DE, Firestone AJ, Settleman J, Hahn WC, Aguirre AJ. Sulahian R, et al. Among authors: Firestone AJ. Cell Rep. 2019 Oct 1;29(1):118-134.e8. doi: 10.1016/j.celrep.2019.08.090. Cell Rep. 2019. PMID: 31577942 Free PMC article.
A three-drug combination to treat BRAF-mutant cancers.
Firestone AJ, Settleman J. Firestone AJ, et al. Nat Med. 2017 Aug 4;23(8):913-914. doi: 10.1038/nm.4382. Nat Med. 2017. PMID: 28777790 No abstract available.
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. Burgess MR, et al. Among authors: Firestone AJ. Cell. 2017 Feb 23;168(5):817-829.e15. doi: 10.1016/j.cell.2017.01.020. Epub 2017 Feb 16. Cell. 2017. PMID: 28215705 Free PMC article.
Arhgap36-dependent activation of Gli transcription factors.
Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK. Rack PG, et al. Among authors: Firestone AJ. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11061-6. doi: 10.1073/pnas.1322362111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024229 Free PMC article.
Preclinical efficacy of MEK inhibition in Nras-mutant AML.
Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Burgess MR, et al. Among authors: Firestone AJ. Blood. 2014 Dec 18;124(26):3947-55. doi: 10.1182/blood-2014-05-574582. Epub 2014 Oct 31. Blood. 2014. PMID: 25361812 Free PMC article.
Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place.
Doughman RL, Firestone AJ, Anderson RA. Doughman RL, et al. Among authors: Firestone AJ. J Membr Biol. 2003 Jul 15;194(2):77-89. doi: 10.1007/s00232-003-2027-7. J Membr Biol. 2003. PMID: 14502432 Review.
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, Carias H, Dickens D, Loh M, Shannon K, Firestone AJ. White Y, et al. Among authors: Firestone AJ. Nat Commun. 2016 Feb 8;7:10647. doi: 10.1038/ncomms10647. Nat Commun. 2016. PMID: 26854029 Free PMC article.
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Zambetti NA, et al. Among authors: Firestone AJ. Blood. 2020 May 14;135(20):1772-1782. doi: 10.1182/blood.2019003530. Blood. 2020. PMID: 32219446
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