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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 6
1948 6
1949 13
1950 22
1951 37
1952 55
1953 45
1954 54
1955 56
1956 58
1957 43
1958 50
1959 66
1960 54
1961 67
1962 62
1963 82
1964 99
1965 116
1966 106
1967 158
1968 134
1969 188
1970 161
1971 173
1972 194
1973 168
1974 154
1975 178
1976 142
1977 156
1978 128
1979 118
1980 107
1981 110
1982 109
1983 130
1984 140
1985 153
1986 201
1987 174
1988 258
1989 224
1990 212
1991 162
1992 193
1993 184
1994 237
1995 239
1996 321
1997 435
1998 618
1999 866
2000 1195
2001 1261
2002 1286
2003 1328
2004 1312
2005 1494
2006 1540
2007 1740
2008 1743
2009 1785
2010 2116
2011 1979
2012 1845
2013 1926
2014 2098
2015 2136
2016 2114
2017 2310
2018 2250
2019 1520
2020 41
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39,276 results
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Anti-inflammatory effects of flavonoids.
Maleki SJ, et al. Food Chem 2019 - Review. PMID 31288163
Recent studies have demonstrated that flavonoids can inhibit regulatory enzymes or transcription factors important for controlling mediators involved in inflammation. Flavonoids are also known as potent antioxidants with the potential to attenuate tissue damage or fibrosis. Consequently, numerous studies in vitro and in animal models have found that flavonoids have the potential to inhibit the onset and development of inflammatory diseases. ...
Recent studies have demonstrated that flavonoids can inhibit regulatory enzymes or transcription factors important for controlling me …
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases.
Maher P. Int J Mol Sci 2019 - Review. PMID 31234550 Free PMC article.
In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases....
In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common m …
Flavonoids in Health and Disease.
López JG. Curr Med Chem 2019. PMID 31920188
Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases.
Vazhappilly CG, et al. Inflammopharmacology 2019 - Review. PMID 31309484
For decades, plant polyphenols, especially flavonoids, were known for their vital role in preventing various diseases such as cancer. ...Although the role of flavonoids in CVD is widely discussed, to the best of our knowledge, their role as anti-thrombotic lead has not been discussed. ...
For decades, plant polyphenols, especially flavonoids, were known for their vital role in preventing various diseases such as cancer. …
Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue.
Boniface PK and Ferreira EI. Phytother Res 2019 - Review. PMID 31441148
Flavonoids are a class of compounds that has been the subject of considerable scientific interest. New developments of flavonoids have made promising advances for the potential treatment of malaria, leishmaniasis, Chagas disease, and dengue, with less toxicity, high efficacy, and improved bioavailability. ...Natural and synthetic flavonoids are leading compounds that can be used for developing antiprotozoal and antiviral agents. However, detailed studies on toxicity, pharmacokinetics, and mechanisms of action of these compounds are required to confirm the in vitro pharmacological claims of flavonoids for pharmaceutical applications. ...
Flavonoids are a class of compounds that has been the subject of considerable scientific interest. New developments of flavonoids
Flavonoids Ability to Disrupt Inflammation Mediated by Lipid and Cholesterol Oxidation.
Barnaba C and Medina-Meza IG. Adv Exp Med Biol 2019. PMID 31562634
These findings have opened an intensive field of research on the effects of flavonoids and flavonoids-rich food extracts in cardiovascular diseases (CVD) progression, particularly in the modulating CVD-associated oxidative stress and inflammation. In this short review, we will summarize the current findings in flavonoids beneficial effects in preventing CVD through inhibition of initial stages of CVD progression. ...
These findings have opened an intensive field of research on the effects of flavonoids and flavonoids-rich food extracts in ca …
Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis.
Vallance TM, et al. Int J Mol Sci 2019 - Review. PMID 31242657 Free PMC article.
Despite these, flavonoids act as versatile templates for the design and synthesis of novel molecules for various therapeutic targets. ...Here, we provide insight into the actions of certain natural flavonoids along with the advantages of synthetic flavonoids in the modulation of platelet function, haemostasis, and thrombosis....
Despite these, flavonoids act as versatile templates for the design and synthesis of novel molecules for various therapeutic targets. …
Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile.
Peixoto JC, et al. Molecules 2019 - Review. PMID 31395797 Free PMC article.
Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant diversity with emphasis on the families of flavonoid-producing plants, and then we describe the phenylpropanoid pathway which represents the flavonoids' main route biosynthesis-generally conserved in all species. ...
Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This
Antidiabetic Potential of Flavonoids from Traditional Chinese Medicine: A Review.
Bai L, et al. Am J Chin Med 2019 - Review. PMID 31248265
Flavonoids are widely distributed in plants, and many studies have shown that flavonoids possess antidiabetic properties, exhibiting not only well-recognized antidiabetic and hypoglycemic activities but also activity in the treatment of diabetic complications. ...Apigenin, baicalein, and catechin mainly reduces blood glucose via anti-oxidation; hesperidin is good for diabetic neuropathy; glycyrrhiza flavonoids have a significant effect on gestational DM; quercetin takes advantage of crossing the blood-brain barrier and improving renal function. ...
Flavonoids are widely distributed in plants, and many studies have shown that flavonoids possess antidiabetic properties, exhi
Progress in Research on the Role of Flavonoids in Lung Cancer.
Zanoaga O, et al. Int J Mol Sci 2019 - Review. PMID 31480720 Free PMC article.
Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention and of particular interest is the dose used for these studies, to underline the molecular effects and mechanisms at a physiological concentration. ...
Natural bioactive compounds and particular flavonoids compounds have been proven to have an important role in lung cancer prevention …
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