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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 7
1986 13
1987 63
1988 69
1989 118
1990 119
1991 96
1992 101
1993 98
1994 81
1995 106
1996 95
1997 86
1998 70
1999 62
2000 85
2001 88
2002 81
2003 119
2004 128
2005 131
2006 149
2007 120
2008 127
2009 138
2010 120
2011 140
2012 152
2013 166
2014 188
2015 152
2016 136
2017 147
2018 170
2019 105
2020 2
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3,566 results
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Page 1
Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Bidell MR and Lodise TP. Pharmacotherapy 2016 - Review. PMID 27138564
Fluoroquinolone antibiotics recently have gained increased national attention due to safety concerns. A well-described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture. ...Due to the severity of these adverse events, a black box warning is included in the product labeling of all fluoroquinolones. ...
Fluoroquinolone antibiotics recently have gained increased national attention due to safety concerns. A well-described and serious
Weighing the adverse cardiac effects of fluoroquinolones: A risk perspective.
Mehrzad R and Barza M. J Clin Pharmacol 2015 - Review. PMID 26011799
A rare side effect of fluoroquinolone (FQ) antibiotics is QT prolongation, which may result in serious arrhythmias. Most published comparative trials describe the relative risks among the drug class but do not focus on the incidence of serious arrhythmias. ...A review of English-language literature was performed to identify trials that provide data on the relative risk and, when able to be calculated, the incidence of adverse cardiac events among the commonly used FQs. ...
A rare side effect of fluoroquinolone (FQ) antibiotics is QT prolongation, which may result in serious arrhythmias. Most published co …
Aortic Dissection and Aortic Aneurysms Associated with Fluoroquinolones: A Systematic Review and Meta-Analysis.
Singh S and Nautiyal A. Am J Med 2017 - Review. PMID 28739200
Current use of fluoroquinolones was associated with a statistically significantly increased risk of aortic dissection (OR, 2.79; 95% confidence interval [CI], 2.31-3.37; I(2) = 0%) and aortic aneurysm (OR, 2.25; 95% CI, 2.03-2.49; I(2) = 0%) in a fixed-effects meta-analysis. The unadjusted OR estimates and sensitivity analysis using a random-effects model showed similar results. We rated the strength of evidence to be of moderate quality. ...
Current use of fluoroquinolones was associated with a statistically significantly increased risk of aortic dissection (OR, 2.79; 95% …
Fluoroquinolones increase the risk of serious arrhythmias: A systematic review and meta-analysis.
Liu X, et al. Medicine (Baltimore) 2017 - Review. PMID 29095256 Free PMC article.
BACKGROUND: The association between oral fluoroquinolones (FQs) usage and risk of severe arrhythmia-related events (ventricular arrhythmias and sudden cardiac death) remains controversial. Therefore we aimed to quantify this association and to evaluate the effects of FQs on adverse cardiovascular (CV) outcomes. METHODS: We retrieved data from the Cochrane Collaboration, PubMed, and China National Knowledge Infrastructure (CNKI) databases until August 2017. ...
BACKGROUND: The association between oral fluoroquinolones (FQs) usage and risk of severe arrhythmia-related events (ventricular arrhy …
Tendon Injury and Fluoroquinolone Use: A Systematic Review.
Stephenson AL, et al. Drug Saf 2013 - Review. PMID 23888427
Tendon injury has been associated with the use of these medications but the risk associated with newer fluoroquinolones has not been established. ...Five studies stated that individuals taking fluoroquinolones and oral corticosteroids are at increased risk for tendon injury compared with those taking fluoroquinolones alone. ...
Tendon injury has been associated with the use of these medications but the risk associated with newer fluoroquinolones has not been …
Fluoroquinolone-associated tendinopathy.
Tsai WC and Yang YM. Chang Gung Med J 2011 - Review. PMID 22035890 Free article.
The fluoroquinolones (FQs) are used to treat a wide range of infections because of their excellent gastrointestinal absorption, superior tissue penetration and broad-spectrum activity. ...However, these adverse effects do not appear to be widely known among physicians. Because of the frequent use of FQs in clinical practice, physicians should be aware of their potential for severe disability from tendon rupture. ...
The fluoroquinolones (FQs) are used to treat a wide range of infections because of their excellent gastrointestinal absorption, super …
Assessing fluoroquinolone-associated aortic aneurysm and dissection: Data mining of the public version of the FDA adverse event reporting system.
Meng L, et al. Int J Clin Pract 2019. PMID 30809871
Sensitivity analyses that limited the data by gender and adverse event date also showed similar trends. RESULTS: Based on 3721 adverse event reports, all three fluoroquinolones are associated with aortic aneurysm, and levofloxacin is associated with aortic dissection. ...Oral administration of fluoroquinolones is more likely to produce these adverse events. CONCLUSION: The results obtained herein are consistent with clinical observations, suggesting the necessity for further clinical research on aortic aneurysm and dissection associated with fluoroquinolones....
Sensitivity analyses that limited the data by gender and adverse event date also showed similar trends. RESULTS: Based on 3721 adv
When antibiotics turn toxic
Marchant J. Nature 2018. PMID 29565407
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