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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1992 1
1994 3
1995 3
1996 13
1997 23
1998 30
1999 39
2000 38
2001 51
2002 45
2003 43
2004 55
2005 61
2006 76
2007 71
2008 102
2009 97
2010 84
2011 95
2012 98
2013 95
2014 81
2015 92
2016 84
2017 89
2018 93
2019 36
2020 0
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1,466 results
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Page 1
Frizzled Receptors in Development and Disease.
Wang Y, et al. Curr Top Dev Biol 2016 - Review. Among authors: Rattner A. PMID 26969975 Free PMC article.
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. ...Frizzled receptors are ubiquitous among multicellular animals and, with other signaling molecules, they very likely evolved to permit the development of the complex tissue architectures that provide multicellular animals with their enormous selective advantage....
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together wit
Frizzled Receptors as Potential Therapeutic Targets in Human Cancers.
Zeng CM, et al. Int J Mol Sci 2018 - Review. PMID 29789460 Free PMC article.
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. ...In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. ...
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled rec
Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors.
Zhang X, et al. Trends Biochem Sci 2018 - Review. PMID 30309741
Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled receptors (FZDs), are responsible for mediating fundamental signaling in embryonic development and tissue homeostasis. ...Here, we review all reported frizzled family structures and diverse signalosome models, with an emphasis on the different ligand binding sites and lipid binding grooves, aiming to uncover the druggability landscape of the frizzled GPCR family....
Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
Tao L, et al. Nature 2016. PMID 27680706 Free PMC article.
Here we carried out CRISPR-Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (FZDs) as TcdB receptors. ...These findings establish FZDs as physiologically relevant receptors for TcdB in the colonic epithelium....
Here we carried out CRISPR-Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (F …
Deregulation of Frizzled Receptors in Hepatocellular Carcinoma.
Chan KK and Lo RC. Int J Mol Sci 2018 - Review. PMID 29361730 Free PMC article.
Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. ...
Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed
Expression of the Frizzled receptors and their co-receptors in calcified human aortic valves.
Siddique A, et al. Can J Physiol Pharmacol 2018. Among authors: Rheaume E. PMID 29244962
However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6 in normal and diseased human aortic valves remains to be elucidated. ...These results were confirmed by immunohistochemistry, which revealed abundant increase in immunoreactivity for Fzd3, 7, and 8, mainly in areas of lipid core and calcified nodules of diseased aortic valves. ...
However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6 in normal and diseased human aortic v …
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, et al. Nat Chem Biol 2018. PMID 29632413
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5). The Frizzled (FZD) 7 receptor (FZD7) is enriched in LGR5(+) intestinal stem cells and plays a critical role in their self-renewal. ...
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the cry
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.
Farin HF, et al. Nature 2016. PMID 26863187
Plasma membrane localization requires surface expression of Frizzled receptors, which in turn is regulated by the transmembrane E3 ligases Rnf43/Znrf3 and their antagonists Lgr4-5/R-spondin. ...We conclude that stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient....
Plasma membrane localization requires surface expression of Frizzled receptors, which in turn is regulated by th …
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Steinhart Z, et al. Nat Med 2017. Among authors: Robitaille M. PMID 27869803
Through these screens, we discovered a unique requirement for a Wnt signaling circuit: engaging FZD5, one of the ten Frizzled receptors encoded in the human genome. Our results uncover an underappreciated level of context-dependent specificity at the Wnt receptor level. We further derived a panel of recombinant antibodies that reports the expression of nine FZD proteins and confirms that FZD5 functional specificity cannot be explained by protein expression patterns. ...
Through these screens, we discovered a unique requirement for a Wnt signaling circuit: engaging FZD5, one of the ten Frizzled
Alternative Wnt Signaling Activates YAP/TAZ
Park HW, et al. Cell 2015. PMID 26276632 Free PMC article.
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. ...Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. ...
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contri …
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