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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 3
2006 20
2007 20
2008 33
2009 24
2010 32
2011 26
2012 29
2013 20
2014 27
2015 27
2016 42
2017 44
2018 54
2019 16
2020 0
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369 results
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Page 1
Frizzled Receptors in Development and Disease.
Wang Y, et al. Curr Top Dev Biol 2016 - Review. Among authors: Rattner A. PMID 26969975 Free PMC article.
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. ...Frizzled receptors are ubiquitous among multicellular animals and, with other signaling molecules, they very likely evolved to permit the development of the complex tissue architectures that provide multicellular animals with their enormous selective advantage....
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together wit
Frizzled Receptors as Potential Therapeutic Targets in Human Cancers.
Zeng CM, et al. Int J Mol Sci 2018 - Review. PMID 29789460 Free PMC article.
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. ...In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. ...
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled rec
Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors.
Zhang X, et al. Trends Biochem Sci 2018 - Review. PMID 30309741
Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled receptors (FZDs), are responsible for mediating fundamental signaling in embryonic development and tissue homeostasis. ...Here, we review all reported frizzled family structures and diverse signalosome models, with an emphasis on the different ligand binding sites and lipid binding grooves, aiming to uncover the druggability landscape of the frizzled GPCR family....
Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.
Tao L, et al. Nature 2016. PMID 27680706 Free PMC article.
Here we carried out CRISPR-Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (FZDs) as TcdB receptors. ...These findings establish FZDs as physiologically relevant receptors for TcdB in the colonic epithelium....
Here we carried out CRISPR-Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (F …
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nile AH, et al. Nat Chem Biol 2018. PMID 29632413
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5). The Frizzled (FZD) 7 receptor (FZD7) is enriched in LGR5(+) intestinal stem cells and plays a critical role in their self-renewal. ...
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the cry
Deregulation of Frizzled Receptors in Hepatocellular Carcinoma.
Chan KK and Lo RC. Int J Mol Sci 2018 - Review. PMID 29361730 Free PMC article.
Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. ...
Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed
A molecular mechanism for Wnt ligand-specific signaling
Eubelen M, et al. Science 2018. PMID 30026314
This selective Wnt recognition or "decoding" capacity has remained enigmatic because Wnt/Frizzled interactions are largely incompatible with monospecific recognition. ...Availability of Reck-bound Wnt7 for Frizzled signaling relies on the interaction between Gpr124 and Dishevelled. Through polymerization, Dishevelled recruits Gpr124 and the associated Reck-bound Wnt7 into dynamic Wnt/Frizzled/Lrp5/6 signalosomes, resulting in increased local concentrations of Wnt7 available for Frizzled signaling. ...
This selective Wnt recognition or "decoding" capacity has remained enigmatic because Wnt/Frizzled interactions are larg …
Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt).
Yang Y and Mlodzik M. Annu Rev Cell Dev Biol 2015 - Review. PMID 26566118 Free PMC article.
A key conserved pathway regulating PCP, the so-called core Wnt-Frizzled PCP (Fz/PCP) signaling pathway, was initially identified through genetic studies of Drosophila. ...These studies have shifted focus to the role of Van Gogh (Vang)/Vangl genes in this molecular system. This review focuses on new insights into the core Fz/Vangl/PCP pathway and recent advances in Drosophila and vertebrate PCP studies. ...
A key conserved pathway regulating PCP, the so-called core Wnt-Frizzled PCP (Fz/PCP) signaling pathway, was initially identifi …
mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level.
Zeng H, et al. Proc Natl Acad Sci U S A 2018. Among authors: Roma G, Reece-Hoyes J, Russ C. PMID 30297426 Free PMC article.
Deficiency in tuberous sclerosis complex 1/2 (TSC1/2), core negative regulators of mTORC1 activity, represses Wnt/β-catenin target gene expression, which can be rescued by RAD001. Mechanistically, mTORC1 signaling regulates the cell surface level of Wnt receptor Frizzled (FZD) in a Dishevelled (DVL)-dependent manner by influencing the association of DVL and clathrin AP-2 adaptor. ...
Deficiency in tuberous sclerosis complex 1/2 (TSC1/2), core negative regulators of mTORC1 activity, represses Wnt/β-catenin ta …
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
Pusapati GV, et al. Dev Cell 2018. Among authors: Rohatgi R. PMID 29290584 Free PMC article.
Most positive regulators identified in our screens, including Rab34, Pdcl, and Tubd1, were involved in ciliary functions, confirming the central role for primary cilia in Hh signaling. Negative regulators identified included Megf8, Mgrn1, and an unannotated gene encoding a tetraspan protein we named Atthog. The function of these negative regulators converged on Smoothened (SMO), an oncoprotein that transduces the Hh signal across the membrane. ...
Most positive regulators identified in our screens, including Rab34, Pdcl, and Tubd1, were involved in ciliary functions, conf …
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