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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 11
1947 12
1948 14
1949 17
1950 21
1951 46
1952 58
1953 62
1954 81
1955 77
1956 65
1957 53
1958 58
1959 45
1960 51
1961 64
1962 78
1963 137
1964 215
1965 175
1966 179
1967 244
1968 313
1969 332
1970 316
1971 394
1972 366
1973 367
1974 388
1975 303
1976 247
1977 253
1978 184
1979 181
1980 153
1981 141
1982 106
1983 120
1984 127
1985 124
1986 137
1987 126
1988 102
1989 157
1990 131
1991 130
1992 118
1993 169
1994 167
1995 157
1996 182
1997 186
1998 190
1999 188
2000 263
2001 268
2002 305
2003 370
2004 397
2005 402
2006 423
2007 501
2008 493
2009 483
2010 485
2011 549
2012 642
2013 670
2014 629
2015 581
2016 611
2017 584
2018 469
2019 236
2020 6
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16,551 results
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Page 1
Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD.
Song M, et al. Nutrients 2018 - Review. PMID 30469339 Free PMC article.
The metabolic effects of fructose on the development of metabolic syndrome and NAFLD are not completely understood. High fructose intake impairs copper status, and copper-fructose interactions have been well documented in rats. ...This review will shed light on the role of copper homeostasis and high fructose intake and point to copper-fructose interactions as novel mechanisms in the fructose induced NAFLD....
The metabolic effects of fructose on the development of metabolic syndrome and NAFLD are not completely understood. High fructose
Intestinal Absorption of Fructose.
Ferraris RP, et al. Annu Rev Nutr 2018 - Review. PMID 29751733 Free PMC article.
Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. ...Finally, it discusses the potential contributions of dietary fructose to gastrointestinal diseases and to the gut microbiome....
Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now …
Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders.
Tappy L. J Exp Biol 2018 - Review. PMID 29514881 Free article.
Compared with other carbohydrates, fructose-containing caloric sweeteners (sucrose, high-fructose corn syrup, pure fructose and fructose-glucose mixtures) are characterized by: a sweet taste generally associated with a positive hedonic tone; specific intestinal fructose transporters, i.e. ...Fructose is a dispensable nutrient, yet its energy can be stored very efficiently owing to a rapid induction of intestinal fructose transporters and of splanchnic fructolytic and lipogenic enzymes by dietary fructose-containing caloric sweeteners. ...
Compared with other carbohydrates, fructose-containing caloric sweeteners (sucrose, high-fructose corn syrup, pure fructose
Fructose at the crossroads of the metabolic syndrome and obesity epidemics.
Mortera RR, et al. Front Biosci (Landmark Ed) 2019 - Review. PMID 30468651
The hormones involved in satiety control are affected by fructose consumption. Fructose derived advance glycation end-products  may also induce a state of inflammation by engaging its receptor, RAGE. Directionality for the effect of fructose on metabolic syndrome is becoming clear: fructose drives hepatic fat, which in turn drives insulin resistance. ...
The hormones involved in satiety control are affected by fructose consumption. Fructose derived advance glycation end-products …
Dietary Fructose and the Metabolic Syndrome.
Taskinen MR, et al. Nutrients 2019 - Review. PMID 31443567 Free PMC article.
Fructose is absorbed in the small intestine and metabolized in the liver where it stimulates fructolysis, glycolysis, lipogenesis, and glucose production. ...Therefore, understanding the mechanisms underlying intestinal and hepatic fructose metabolism is important. Here we review recent evidence linking excessive fructose consumption to health risk markers and development of components of the Metabolic Syndrome....
Fructose is absorbed in the small intestine and metabolized in the liver where it stimulates fructolysis, glycolysis, lipogenesis, an
Recent insights into the role of ChREBP in intestinal fructose absorption and metabolism.
Lee HJ and Cha JY. BMB Rep 2018 - Review. PMID 30158026 Free PMC article.
Fructose in the form of sucrose and high fructose corn syrup is absorbed by the intestinal transporter and mainly metabolized in the small intestine. However, excess intake of fructose overwhelms the absorptive capacity of the small intestine, leading to fructose malabsorption. ...
Fructose in the form of sucrose and high fructose corn syrup is absorbed by the intestinal transporter and mainly metabolized
Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.
Johnson RJ, et al. BMC Nephrol 2018 - Clinical Trial. PMID 30409184 Free PMC article.
BACKGROUND: Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation. METHODS: We analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. ...
BACKGROUND: Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associa …
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Lanaspa MA, et al. J Clin Invest 2018. PMID 29533924 Free PMC article.
Hereditary fructose intolerance (HFI) is a difficult and potentially lethal orphan disease associated with impaired fructose metabolism. ...Unfortunately, there is currently no treatment for HFI, and avoiding sugar and fructose has become challenging in our society. ...
Hereditary fructose intolerance (HFI) is a difficult and potentially lethal orphan disease associated with impaired fructose m …
Fructose-Induced Insulin Resistance as a Model of Neuropathic Pain in Rats.
García G, et al. Neuroscience 2019. PMID 30742965
In this study, we investigated fructose-induced insulin resistance as a model of neuropathic pain. Insulin resistance was induced by 15% fructose in drinking water for 16 weeks. ...In contrast, fructose did not change TRPV1 channel protein expression. Treatment with metformin for 4 weeks reversed some of the fructose-induced changes in protein expression. ...
In this study, we investigated fructose-induced insulin resistance as a model of neuropathic pain. Insulin resistance was induced by …
Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.
Bu P, et al. Cell Metab 2018. PMID 29706565 Free PMC article.
In particular, via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or reducing dietary fructose significantly reduces liver metastatic growth but has little effect on the primary tumor. ...
In particular, via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism …
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