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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 1
1971 1
1974 2
1975 22
1976 83
1977 65
1978 60
1979 53
1980 65
1981 66
1982 74
1983 54
1984 58
1985 62
1986 63
1987 69
1988 89
1989 64
1990 90
1991 71
1992 61
1993 58
1994 57
1995 55
1996 60
1997 58
1998 74
1999 79
2000 92
2001 92
2002 89
2003 90
2004 91
2005 90
2006 79
2007 84
2008 101
2009 102
2010 103
2011 98
2012 111
2013 116
2014 92
2015 83
2016 84
2017 87
2018 89
2019 28
2020 1
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3,225 results
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Page 1
Consistent success in life-supporting porcine cardiac xenotransplantation
Längin M, et al. Nature 2018. PMID 30518863
Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons(5). ...Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. ...
Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a …
The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells.
Bydlinski N, et al. J Biotechnol 2018. PMID 30017654 Free article.
Galactosylation as part of N-glycan processing is conducted by a set of beta-1,4-galactosyltransferases (B4GALTs), with B4GALT1 as the dominant isoenzyme for this reaction. ...In the context of high productivity cell lines, which can push N-glycan maturation towards incomplete galactosylation, galactosyltransferases are potential targets to ensure stable product quality. ...
Galactosylation as part of N-glycan processing is conducted by a set of beta-1,4-galactosyltransferases (B4GALTs), with B4GALT
Tick galactosyltransferases are involved in α-Gal synthesis and play a role during Anaplasma phagocytophilum infection and Ixodes scapularis tick vector development.
Cabezas-Cruz A, et al. Sci Rep 2018. PMID 30242261 Free PMC article.
In this study, the Ixodes scapularis genome was searched for galactosyltransferases and three genes were identified as potentially involved in the synthesis of α-Gal. ...These results provided the molecular basis of endogenous α-Gal production in ticks and suggested that tick galactosyltransferases are involved in vector development, tick-pathogen interactions and possibly the etiology of α-Gal syndrome in humans....
In this study, the Ixodes scapularis genome was searched for galactosyltransferases and three genes were identified as potentially in …
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation
Mayo L, et al. Nat Med 2014. PMID 25216636 Free PMC article.
Here we report that lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system (CNS) of mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). ...
Here we report that lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central ne …
Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases.
Huang K, et al. Org Biomol Chem 2019. PMID 31165848
Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial β1,4-galactosyltransferases to catalyse the transgalactosylation from lactose to N-acetylglucosamine to form N-acetyllactosamine in the presence of UDP. The process is demonstrated by the preparative scale synthesis of pNP-β-LacNAc from lactose using β1,4-galactosyltransferase NmLgtB-B as the only biocatalyst....
Utilising a fast and sensitive screening method based on imidazolium-tagged probes, we report unprecedented reversible activity of bacterial …
Identification of three potent hydroxyproline O-galactosyltransferases in Arabidopsis.
Ogawa-Ohnishi M and Matsubayashi Y. Plant J 2015. PMID 25600942 Free article.
AGP biosynthesis involves O-galactosylation of hydroxyproline (Hyp) residues followed by a stepwise elongation of the complex sugar chains. ...Here, we purified and identified three potent Hyp O-galactosyltransferases, HPGT1, HPGT2 and HPGT3, from Arabidopsis microsomal fractions. ...
AGP biosynthesis involves O-galactosylation of hydroxyproline (Hyp) residues followed by a stepwise elongation of the complex sugar c …
Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice
Chugh S, et al. Gastroenterology 2018. PMID 30086262 Free PMC article.
Dysregulated activity of core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (C1GALT1) leads to increased expression of these truncated O-glycans. ...
Dysregulated activity of core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (C1GALT1) leads to increased …
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