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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1947 8
1948 4
1949 2
1950 13
1951 10
1952 13
1953 38
1954 19
1955 24
1956 34
1957 48
1958 59
1959 58
1960 59
1961 72
1962 106
1963 120
1964 153
1965 323
1966 454
1967 510
1968 741
1969 893
1970 830
1971 975
1972 1165
1973 1448
1974 2024
1975 1780
1976 1873
1977 1799
1978 1894
1979 2184
1980 2129
1981 2347
1982 2539
1983 2598
1984 2944
1985 3175
1986 3420
1987 3908
1988 4281
1989 5507
1990 7916
1991 8695
1992 9482
1993 10099
1994 11182
1995 11841
1996 11700
1997 11645
1998 11907
1999 11594
2000 12437
2001 13277
2002 12799
2003 12911
2004 13222
2005 13931
2006 15161
2007 14862
2008 14894
2009 13413
2010 13549
2011 15696
2012 19012
2013 20821
2014 20582
2015 21062
2016 20682
2017 20368
2018 17760
2019 9001
2020 178
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441,746 results
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Page 1
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges.
Pichon X, et al. Mol Cell 2018 - Review. PMID 30075145 Free article.
We present how they advanced our understanding of gene expression heterogeneity and bursting, as well as the spatiotemporal aspects of splicing, translation, and RNA decay. These insights yield a dynamic and stochastic view of gene expression in single cells....
We present how they advanced our understanding of gene expression heterogeneity and bursting, as well as the spatiotemporal as …
The core promoter: At the heart of gene expression.
Danino YM, et al. Biochim Biophys Acta 2015 - Review. PMID 25934543
The identities of different cells and tissues in multicellular organisms are determined by tightly controlled transcriptional programs that enable accurate gene expression. The mechanisms that regulate gene expression comprise diverse multiplayer molecular circuits of multiple dedicated components. ...
The identities of different cells and tissues in multicellular organisms are determined by tightly controlled transcriptional programs that …
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity.
Rodriguez J, et al. Cell 2019. PMID 30554876 Free PMC article.
To understand the relationship between these two phenomena and the dynamic regulation of genes in response to upstream signals, we describe the use of live-cell RNA imaging coupled with Hi-C measurements and dissect the endogenous regulation of the estrogen-responsive TFF1 gene. ...The heterogeneity in inactive times gives rise to the widely observed "noise" in human gene expression and explains the distribution of protein levels in human tissue. ...
To understand the relationship between these two phenomena and the dynamic regulation of genes in response to upstream signals, we describe …
Roadblocks and resolutions in eukaryotic translation
Schuller AP and Green R. Nat Rev Mol Cell Biol 2018 - Review. PMID 29760421 Free PMC article.
We discuss the fundamental stages of the translation process in eukaryotes, from elongation through ribosome recycling, with particular attention to recent discoveries of the complexity of the genetic code and regulatory elements that control gene expression, including ribosome stalling during elongation, the role of mRNA context in translation termination and mechanisms of ribosome rescue that resemble recycling....
We discuss the fundamental stages of the translation process in eukaryotes, from elongation through ribosome recycling, with particular atte …
Analyzing gene expression time-courses based on multi-resolution shape mixture model.
Li Y, et al. Math Biosci 2016. PMID 27621040
Time course gene expression experiments provide opportunities to explore patterns of gene expression change over a time and understand the dynamic behavior of gene expression, which is crucial for study on development and progression of biology and disease. ...We assessed the performance of our proposed algorithm using yeast time-course gene expression profiles compared with several popular clustering methods for gene expression profiles. ...
Time course gene expression experiments provide opportunities to explore patterns of gene expression change over …
In vivo methods for acute modulation of gene expression in the central nervous system.
Cwetsch AW, et al. Prog Neurobiol 2018 - Review. PMID 29694844 Free PMC article.
Accurate and timely expression of specific genes guarantees the healthy development and function of the brain. Indeed, variations in the correct amount or timing of gene expression lead to improper development and/or pathological conditions. Almost forty years after the first successful gene transfection in in vitro cell cultures, it is currently possible to regulate gene expression in an area-specific manner at any step of central nervous system development and in adulthood in experimental animals in vivo, even overcoming the very poor accessibility of the brain. ...
Accurate and timely expression of specific genes guarantees the healthy development and function of the brain. Indeed, variations in …
Genetics of gene expression in CNS.
Pandey AK and Williams RW. Int Rev Neurobiol 2014 - Review. PMID 25172476 Free PMC article.
By combining classic gene mapping methods-family linkage studies and genomewide association-with high-throughput genomics, it is now possible to define quantitative trait loci (QTLs), single-gene variants, and even single SNPs and indels that control gene expression in different brain regions and cells. ...But at a higher level of analysis, we still do not understand the genetic architecture of gene expression in brain, the consequences of expression QTLs on protein levels or on cell function, or the combined impact of expression differences on behavior and disease risk. ...
By combining classic gene mapping methods-family linkage studies and genomewide association-with high-throughput genomics, it is now …
Testing the gene expression classification of the EMT spectrum.
Jia D, et al. Phys Biol 2019. PMID 30557866
Here, to better characterize the hybrid E/M phenotype (s) and tumor aggressiveness, we integrate two computational methods-(a) RACIPE-to identify the robust gene expression patterns emerging from the dynamics of a given gene regulatory network, and (b) EMT scoring metric-to calculate the probability that a given gene expression profile displays a hybrid E/M phenotype. We apply the EMT scoring metric to RACIPE-generated gene expression data generated from a core EMT regulatory network and classify the gene expression profiles into relevant categories (epithelial, hybrid E/M, mesenchymal). ...
Here, to better characterize the hybrid E/M phenotype (s) and tumor aggressiveness, we integrate two computational methods-(a) RACIPE-to ide …
Light and temperature shape nuclear architecture and gene expression.
Kaiserli E, et al. Curr Opin Plant Biol 2018 - Review. PMID 29909288 Free PMC article.
Quantitative and qualitative variations in light and temperature trigger changes in gene expression that ultimately shape plant morphology for adaptation and survival. ...This review presents recent discoveries investigating how changes in light and temperature trigger changes in chromatin structure and nuclear organization with a focus on the role of gene repositioning and chromatin accessibility in regulating gene expression....
Quantitative and qualitative variations in light and temperature trigger changes in gene expression that ultimately shape plan …
441,746 results
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