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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1968 1
1970 2
1971 2
1972 31
1973 75
1974 159
1975 188
1976 240
1977 173
1978 159
1979 225
1980 138
1981 185
1982 167
1983 200
1984 207
1985 134
1986 167
1987 231
1988 276
1989 321
1990 431
1991 331
1992 457
1993 527
1994 657
1995 625
1996 646
1997 564
1998 454
1999 410
2000 468
2001 504
2002 450
2003 450
2004 467
2005 535
2006 703
2007 761
2008 714
2009 655
2010 663
2011 746
2012 760
2013 736
2014 703
2015 718
2016 774
2017 754
2018 767
2019 410
2020 14
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19,608 results
Results by year
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Page 1
The Effects of Hallucinogens on Gene Expression.
Martin DA and Nichols CD. Curr Top Behav Neurosci 2018 - Review. PMID 28677095
These acute molecular processes also influence gene expression changes, which likely influence synaptic plasticity and facilitate more long-term changes in brain neurochemistry ultimately underlying the therapeutic efficacy of a single administration to achieve long-lasting effects. In this review, we summarize what is currently known about the molecular genetic responses to psychedelics within the brain and discuss how gene expression changes may contribute to altered cellular physiology and behaviors....
These acute molecular processes also influence gene expression changes, which likely influence synaptic plasticity and facilit …
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
Lamb J, et al. Science 2006. PMID 17008526 Free article.
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. ...
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we …
The Prediction of Drug-Disease Correlation Based on Gene Expression Data.
Cui H, et al. Biomed Res Int 2018. PMID 29770330 Free PMC article.
Here, we propose an algorithm to specifically predict synergistic effects of drug combinations on various diseases, by integrating the data characteristics of disease-related gene expression profiles with drug-treated gene expression profiles. We have demonstrated utility through its application to transcriptome data, including microarray and RNASeq data, and the drug-disease prediction results were validated using existing publications and drug databases. ...
Here, we propose an algorithm to specifically predict synergistic effects of drug combinations on various diseases, by integra …
Cell-specific prediction and application of drug-induced gene expression profiles.
Hodos R, et al. Pac Symp Biocomput 2018. PMID 29218867 Free PMC article.
Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. ...Hence, we asked whether it is possible to fill these gaps by predicting cell-specific drug perturbation profiles using available expression data from related conditions--i.e. from other drugs and cell types. ...
Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including
Galahad: a web server for drug effect analysis from gene expression.
Laenen G, et al. Nucleic Acids Res 2015. PMID 25940630 Free PMC article.
Galahad (https://galahad.esat.kuleuven.be) is a web-based application for analysis of drug effects. It provides an intuitive interface to be used by anybody interested in leveraging microarray data to gain insights into the pharmacological effects of a drug, mainly identification of candidate targets, elucidation of mode of action and understanding of off-target effects. ...Drug target prioritization is based on the integration of the gene expression data with a functional protein association network. ...
Galahad (https://galahad.esat.kuleuven.be) is a web-based application for analysis of drug effects. It provides an intuitive i …
Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.
Paik H, et al. CPT Pharmacometrics Syst Pharmacol 2016. PMID 27860440 Free PMC article.
We addressed this challenge by evaluating drug-drug relationships using a phenotypic and molecular-based approach that integrates therapeutic indications, side effects, and gene expression profiles induced by each drug. ...We also found that similar gene expressions of drugs do indeed yield similar clinical phenotypes. We generated similarity matrixes of drugs using the expression profiles they induce in a cell line and phenotypic effects....
We addressed this challenge by evaluating drug-drug relationships using a phenotypic and molecular-based approach that integra …
Background gene expression networks significantly enhance drug response prediction by transcriptional profiling.
Torkamani A and Schork NJ. Pharmacogenomics J 2012. PMID 21826086 Free PMC article.
A central goal of gene expression studies coupled with drug response screens is to identify predictive profiles that can be exploited to stratify patients. ...By restricting predictive signatures to direct gene-drug correlations, biologically meaningful interactions that may serve as superior predictors are ignored. ...
A central goal of gene expression studies coupled with drug response screens is to identify predictive profiles that ca …
Gene expression as a target for new drug discovery.
Heguy A, et al. Gene Expr 1995 - Review. PMID 7549465 Free PMC article.
Over the last 7 years we have carried out a major research effort focused on gene transcription as a novel approach to drug discovery. The goal is to identify small molecular weight compounds that modulate the expression of a target gene in a specific manner, thereby either increasing or decreasing the concentration of the corresponding protein product. ...
Over the last 7 years we have carried out a major research effort focused on gene transcription as a novel approach to drug di …
Transcriptomics in toxicology
Joseph P. Food Chem Toxicol 2017 - Review. PMID 28720289 Free PMC article.
Global gene expression changes taking place in biological systems, in response to exposure to xenobiotics, may represent the early and mechanistically relevant cellular events contributing to the onset and progression of xenobiotic-induced adverse health outcomes. Hepatotoxicity and pulmonary toxicity resulting from exposure to xenobiotics are discussed as specific examples to demonstrate the potential application of transcriptomics or global gene expression analysis in the prevention of adverse health effects associated with exposure to xenobiotics....
Global gene expression changes taking place in biological systems, in response to exposure to xenobiotics, may represent the e …
Drug-induced mRNA signatures are enriched for the minority of genes that are highly heritable.
Gao T, et al. Pac Symp Biocomput 2015. PMID 25592599 Free article.
In this paper, we study the relationship between drug effects on the one hand, and heritable and non-heritable factors influencing gene expression on the other. ...We further study this finding in the context of a gene regulatory network. We investigate the relationship between the drug effects on gene expression and propagation of heritable and non-heritable factors through regulatory networks. ...
In this paper, we study the relationship between drug effects on the one hand, and heritable and non-heritable factors influen …
19,608 results
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