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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 1
1966 2
1972 3
1973 1
1974 1
1976 1
1982 5
1983 1
1984 1
1985 6
1986 3
1987 17
1988 5
1989 117
1990 421
1991 825
1992 1046
1993 768
1994 730
1995 993
1996 1145
1997 1129
1998 1705
1999 1413
2000 1708
2001 2000
2002 1881
2003 2037
2004 2449
2005 2738
2006 2929
2007 2531
2008 2184
2009 1928
2010 1882
2011 2011
2012 2267
2013 2361
2014 2601
2015 2628
2016 2437
2017 2438
2018 2979
2019 1597
2020 33
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51,353 results
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Page 1
Emerging Principles of Gene Expression Programs and Their Regulation.
Pope SD and Medzhitov R. Mol Cell 2018 - Review. PMID 30075140 Free article.
Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories based on kinetics of induction, cell-type and signal specificity, and duration of the response. Here we discuss the structure of transcription programs and suggest a basic framework to categorize gene expression programs based on characteristics related to their control mechanisms. ...
Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Trans …
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges.
Pichon X, et al. Mol Cell 2018 - Review. PMID 30075145 Free article.
We present how they advanced our understanding of gene expression heterogeneity and bursting, as well as the spatiotemporal aspects of splicing, translation, and RNA decay. These insights yield a dynamic and stochastic view of gene expression in single cells....
We present how they advanced our understanding of gene expression heterogeneity and bursting, as well as the spatiotemporal as …
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity.
Rodriguez J, et al. Cell 2019. PMID 30554876 Free PMC article.
To understand the relationship between these two phenomena and the dynamic regulation of genes in response to upstream signals, we describe the use of live-cell RNA imaging coupled with Hi-C measurements and dissect the endogenous regulation of the estrogen-responsive TFF1 gene. ...The heterogeneity in inactive times gives rise to the widely observed "noise" in human gene expression and explains the distribution of protein levels in human tissue. ...
To understand the relationship between these two phenomena and the dynamic regulation of genes in response to upstream signals, we describe …
Roadblocks and resolutions in eukaryotic translation
Schuller AP and Green R. Nat Rev Mol Cell Biol 2018 - Review. PMID 29760421 Free PMC article.
We discuss the fundamental stages of the translation process in eukaryotes, from elongation through ribosome recycling, with particular attention to recent discoveries of the complexity of the genetic code and regulatory elements that control gene expression, including ribosome stalling during elongation, the role of mRNA context in translation termination and mechanisms of ribosome rescue that resemble recycling....
We discuss the fundamental stages of the translation process in eukaryotes, from elongation through ribosome recycling, with particular atte …
Maestro of regulation: Riboswitches orchestrate gene expression at the levels of translation, transcription and mRNA decay.
Bastet L, et al. RNA Biol 2018 - Review. PMID 29537923 Free PMC article.
Riboswitches are RNA regulators that control gene expression by modulating their structure in response to metabolite binding. ...Previous reports indicate that riboswitches can control gene expression at the level of translation, transcription or mRNA decay. ...
Riboswitches are RNA regulators that control gene expression by modulating their structure in response to metabolite binding. …
Noise in bacterial gene expression.
Engl C. Biochem Soc Trans 2019 - Review. PMID 30578346
The expression level of a gene can fluctuate significantly between individuals within a population of genetically identical cells. ...Single-cell and single-molecule studies demonstrated that noise within gene expression is influenced by a combination of both intrinsic and extrinsic factors. ...
The expression level of a gene can fluctuate significantly between individuals within a population of genetically identical ce …
In vivo methods for acute modulation of gene expression in the central nervous system.
Cwetsch AW, et al. Prog Neurobiol 2018 - Review. PMID 29694844 Free PMC article.
Accurate and timely expression of specific genes guarantees the healthy development and function of the brain. Indeed, variations in the correct amount or timing of gene expression lead to improper development and/or pathological conditions. Almost forty years after the first successful gene transfection in in vitro cell cultures, it is currently possible to regulate gene expression in an area-specific manner at any step of central nervous system development and in adulthood in experimental animals in vivo, even overcoming the very poor accessibility of the brain. ...
Accurate and timely expression of specific genes guarantees the healthy development and function of the brain. Indeed, variations in …
Age-related gene expression profiles of immature human oocytes.
Smits MAJ, et al. Mol Hum Reprod 2018. PMID 30257015
Gene expression profiles of 38 GV oocytes were determined in four different age groups: 25-30, 31-35, 36-38 and 39-43 years of age. ...Subsequently, GV oocytes were thawed and prepared for gene expression profile analysis using Agilent microarrays containing ~42 000 Human Gene Expression probe-sets. ...
Gene expression profiles of 38 GV oocytes were determined in four different age groups: 25-30, 31-35, 36-38 and 39-43 years of
Analyzing gene expression time-courses based on multi-resolution shape mixture model.
Li Y, et al. Math Biosci 2016. PMID 27621040
Time course gene expression experiments provide opportunities to explore patterns of gene expression change over a time and understand the dynamic behavior of gene expression, which is crucial for study on development and progression of biology and disease. ...We assessed the performance of our proposed algorithm using yeast time-course gene expression profiles compared with several popular clustering methods for gene expression profiles. ...
Time course gene expression experiments provide opportunities to explore patterns of gene expression change over …
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