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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 3
1978 1
1983 2
1985 1
1987 1
1990 1
1992 7
1993 5
1994 262
1995 726
1996 904
1997 1154
1998 1230
1999 1056
2000 932
2001 856
2002 1035
2003 1056
2004 1502
2005 1870
2006 1490
2007 1678
2008 1523
2009 1412
2010 1438
2011 1561
2012 1734
2013 1889
2014 1737
2015 1534
2016 1250
2017 1298
2018 1139
2019 491
2020 8
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30,036 results
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Page 1
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.
Jaenisch R and Bird A. Nat Genet 2003 - Review. PMID 12610534
Many of these differences in gene expression arise during development and are subsequently retained through mitosis. Stable alterations of this kind are said to be 'epigenetic', because they are heritable in the short term but do not involve mutations of the DNA itself. ...Thus, epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression. The extent to which environmental effects can provoke epigenetic responses represents an exciting area of future research....
Many of these differences in gene expression arise during development and are subsequently retained through mitosis. Stable al …
The origins of developmental gene regulation.
Arenas-Mena C. Evol Dev 2017. PMID 28116828
The origins of metazoan developmental gene regulatory mechanisms are sought by analyzing gene regulation in extant eumetazoans, sponges, and unicellular organisms. ...The novel regulatory interactions would have caused constitutively expressed genes controlling differential gene expression in unicellular organisms to become themselves differentially expressed. ...
The origins of metazoan developmental gene regulatory mechanisms are sought by analyzing gene regulation in extant eumetazoans …
Regulatory states in the developmental control of gene expression.
Peter IS. Brief Funct Genomics 2017 - Review. PMID 28444142 Free PMC article.
A growing body of evidence shows that gene expression in multicellular organisms is controlled by the combinatorial function of multiple transcription factors. ...Here, I discuss the concept of the regulatory state and its proposed role in the genome-wide control of gene expression. Recent analyses of regulatory gene expression in sea urchin embryos have been instrumental for solving the genomic control of cell fate specification in this system. ...
A growing body of evidence shows that gene expression in multicellular organisms is controlled by the combinatorial function o …
Developmental effector gene regulation: Multiplexed strategies for functional analysis.
Wang L, et al. Dev Biol 2019. PMID 30392838 Free PMC article.
There emerged the simple conclusion that each effector gene utilizes a small subset of inputs from the skeletogenic GRN. These inputs may function to only adjust expression levels or in some cases necessary for expression. Since we know the GRN architecture upstream of the effector genes, we could then conceptually isolate and compare the wiring of the effector gene driver sub-circuits and identify the inputs whose removal abolish expression....
There emerged the simple conclusion that each effector gene utilizes a small subset of inputs from the skeletogenic GRN. These inputs …
Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.
Horzmann KA, et al. J Proteomics 2018. PMID 30012420 Free PMC article.
Although the transcriptomic alterations in larval zebrafish with embryonic atrazine exposure have been reported, neither the time at which gene expression changes occur nor the resulting proteomic changes have been investigated. This study seeks to address these knowledge gaps by evaluating atrazine's effect on gene expression through multiple time points during embryogenesis, and correlating changes in gene expression to pathological alterations in brain length and functional changes in behavior. ...
Although the transcriptomic alterations in larval zebrafish with embryonic atrazine exposure have been reported, neither the time at which …
Reversed graph embedding resolves complex single-cell trajectories
Qiu X, et al. Nat Methods 2017. PMID 28825705 Free PMC article.
Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex trajectories with multiple branches remains a challenging computational problem. ...
Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex traje …
More than a decade of developmental gene expression atlases: where are we now?
de Boer BA, et al. Nucleic Acids Res 2009 - Review. PMID 19822576 Free PMC article.
To unravel regulatory networks of genes functioning during embryonic development, information on in situ gene expression is required. ...The best way to make these data accessible is via spatio-temporal gene expression atlases. Eleven atlases, describing developing vertebrates and covering at least 100 genes, were reviewed. ...
To unravel regulatory networks of genes functioning during embryonic development, information on in situ gene expression is re …
PAX6: 25th anniversary and more to learn
Cvekl A and Callaerts P. Exp Eye Res 2017 - Review. PMID 27126352
Since Pax6 is also expressed outside of the eye, namely in the central nervous system and pancreas, a number of important insights into the development and function of these organs have been amassed. ...
Since Pax6 is also expressed outside of the eye, namely in the central nervous system and pancreas, a number of important insights in …
Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep.
Robillard JE, et al. Pediatr Res 1995. PMID 8618791
The present study was designed 1) to characterize the ontogeny of renal AT2 gene expression during the last half of gestation in fetal sheep and newborn lambs, 2) to compare changes in AT1 and AT2 gene expression during renal development, 3) to determine the influence of AII in modulating renal AT1 and AT2 gene expression during fetal life, and 4) to characterize the role of cortisol in modulating renal AT2 gene expression during the last trimester of gestation in fetal sheep. ...On the other hand, we observed that cortisol, known to decrease AT1 gene expression in the fetus, had no effect on AT2 gene expression. ...
The present study was designed 1) to characterize the ontogeny of renal AT2 gene expression during the last half of gestation …
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