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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 2
1984 1
1985 1
1986 1
1987 3
1988 5
1989 121
1990 266
1991 327
1992 366
1993 397
1994 427
1995 550
1996 581
1997 603
1998 680
1999 821
2000 723
2001 699
2002 880
2003 1129
2004 1410
2005 1770
2006 2092
2007 2341
2008 2485
2009 2197
2010 2238
2011 2490
2012 2841
2013 3437
2014 3649
2015 4033
2016 3897
2017 3794
2018 3973
2019 1935
2020 38
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47,783 results
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Page 1
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Rees MG, et al. Nat Chem Biol 2016. PMID 26656090 Free PMC article.
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are unknown. ...
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can co …
Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
Urbanski LM, et al. Wiley Interdiscip Rev RNA 2018 - Review. PMID 29693319 Free PMC article.
Furthermore, the composition of the tumor microenvironment can also influence which isoforms are expressed in a given cell type and impact drug responses. ...
Furthermore, the composition of the tumor microenvironment can also influence which isoforms are expressed in a given cell type and i …
Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review).
Fang LL, et al. Int J Mol Med 2017 - Review. PMID 29039606 Free PMC article.
MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and control gene expression in eukaryotes by degrading mRNA at the post‑transcriptional level. ...Originally identified as being involved in tumorigenesis, it is currently evident that the expression of the miR‑17‑92 cluster is upregulated in a wide range of tumor cells and cancer types; thus, this cluster has been identified as a potential oncogene. ...
MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and control gene expression in eukaryotes by d …
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
Nyamao RM, et al. Biochim Biophys Acta Rev Cancer 2019 - Review. PMID 30419318
The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathways. ...
The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and …
Base excision repair regulates PD-L1 expression in cancer cells.
Permata TBM, et al. Oncogene 2019. PMID 30755733
Herein, we demonstrate that oxidative DNA damage induced by exogenously applied hydrogen peroxide (H(2)O(2)) upregulates PD-L1 expression in cancer cells. ...Further analysis of The Cancer Genome Atlas revealed that the expression of PD-L1 is negatively correlated with that of the BER/single-strand break repair (SSBR) and tumours with low BER/SSBR gene expression show high microsatellite instability and neoantigen production. ...
Herein, we demonstrate that oxidative DNA damage induced by exogenously applied hydrogen peroxide (H(2)O(2)) upregulates PD-L1 expression
Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges
Shankar E, et al. Semin Cancer Biol 2016 - Review. PMID 27117759 Free PMC article.
Although the effects of dietary phytochemicals on gene expression and signaling pathways have been widely studied in cancer, the impact of these dietary compounds on mammalian epigenome is rapidly emerging. ...
Although the effects of dietary phytochemicals on gene expression and signaling pathways have been widely studied in cancer, t …
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